C B Giray

Hacettepe University, Ankara, Ankara, Turkey

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Publications (5)7.9 Total impact

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    ABSTRACT: For many drugs, buccal route offers many advantages over conventional routes of delivery with an improved bioavailability due to the avoidance of degradation in the gastrointestinal tract and hepatic first-pass metabolism. However, the major limitation to buccal drug delivery is the permeability barrier in the buccal mucosa. Use of penetration enhancers appears to be a pertinent approach to increase the drug permeation through the buccal epithelium. Buccal bioadhesive tablet formulations enable a delivery with a plasma drug level of the desired therapeutic response for a defined period of time, and also provides a means of confining the drug and penetration enhancer to a defined region of the mucosa. In this study, a bioadhesive tablet formulation for buccal delivery was designed using a mixture of hydroxypropyl methylcellulose and carbomer, incorporated with a penetration enhancer, sodium glycodeoxycholate (GDC). In vitro bioadhesion property of the formulated tablet was examined and histological study was carried out to examine an in vivo interaction between the tablet and tissue. GDC did not affect the adhesiveness of the tablet which makes it an acceptable excipient for a buccal bioadhesive drug delivery system. Histological changes such as loss of upper cell layers and formation of vacuoles as well swelling in the cells were observed in the buccal epithelium, after 4 h contact with the tablets containing GDC. Studies on reversibility of the interaction are in progress.
    International Journal of Pharmaceutics 01/1998; · 3.99 Impact Factor
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    C B Giray, A Atasever, B Durgun, K Araz
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    ABSTRACT: The use of tissue adhesives as an alternative to or replacement for sutures in wound closure has long been an area of interest. One of these tissue adhesives is a cyanoacrylate. In 15 patients, who underwent root resections of the upper incisors on both sides, the incision lines were closed with silk sutures on one side and by n-butyl-2-cyanoacrylate on the other side of the frenum. Clinical comparison was made on the 1st, 2nd, 3rd, 7th, 14th and 21st postoperative days. On the seventh postoperative day following the removal of sutures and the coating, small punch biopsies were obtained from n-butyl-2-cyanoacrylate treated and sutured sides. The tissue specimens were examined under transmission electron microscope. Clinical observations revealed that on the third and seventh postoperative days epithelialization was better on the sides treated with n-butyl-2-cyanoacrylate. On the twenty-first postoperative day it was observed that the scar formation was significantly more marked and there was more local inflammation during the healing period on the sutured side. Electron microscopic observations of both tissue specimens revealed normal ultrastructural morphology.
    Australian Dental Journal 09/1997; 42(4):255-8. · 1.37 Impact Factor
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    ABSTRACT: Ossifying fibroma is a benign tumor of connective tissue origin which occurs in fibro-osseous lesions. The lesion is seen most commonly in children and young adults. It is asymptomatic and slow-growing, but in some cases may show aggressive behavior. Though it has a slight predilection for the mandible, it may involve both jaws. The lesion is generally asymptomatic until it produces noticeable swelling, and mild deformity and migrations of teeth may be an early clinical feature. Pediatricians and dentists must be aware when asymmetry of the face occurs, and the lesion must be well diagnosed as it has a cancer-like radiographic appearance. In this article a nine-year-old patient with a massive mandibular ossifying fibroma is presented.
    The Turkish journal of pediatrics 01/1996; 38(2):265-70. · 0.56 Impact Factor
  • C B Giray, A Sungur, A Atasever, K Araz
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    ABSTRACT: The synthetic tissue adhesive n-butyl-2-cyanoacrylate (Histoacryl Blue) and silk sutures were compared on the backs of guinea-pigs as the means for closing skin incisions. On the post-operative 3rd, 7th, 14th and 21st days, specimens from each group were obtained and evaluated under light microscopy. Sections were analysed for the degree of inflammation, giant cell reaction, fibroblastic and capillary cell activity and were ranked statistically. The results showed that the silk sutures caused severe inflammatory and giant cell reaction when compared with Histoacryl and the healing process was slower than with n-butyl-2-cyanoacrylate.
    Australian Dental Journal 03/1995; 40(1):43-5. · 1.37 Impact Factor
  • C B Giray, D Us, C Güney, K Araz
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    ABSTRACT: In this study, the antibacterial and cytotoxic effects of a synthetic tissue adhesive called n-butyl-2-cyanoacrylate (Histoacryl) which provide rapid healing in incision in oral surgical procedures were investigated. The antibacterial effects of Histoacryl were tested by using standard reference strains of Streptococcus pyogenes, Streptococcus mitis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus grown in Mueller-Hinton media (sheep blood supplemented Mueller-Hinton for streptococcus strains) by diffusion technique. The cytotoxic effects were also researched on continuous Vero and primary gingival fibroblast cell cultures by using agar overlay method. In these methods, the inhibition zones produced by Histoacryl were evaluated. As a result, Histoacryl was found to have antibacterial effect on the tested bacteria and produce cytotoxic and cytopathic effects on the tested cell cultures.
    Mikrobiyoloji bülteni 05/1993; 27(2):154-63. · 0.61 Impact Factor