H Arai

The University of Tokyo, Tokyo, Tokyo-to, Japan

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  • H Arai
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    ABSTRACT: Vitamin E occurs in nature in eight different forms, but animal body is enriched in alpha-tocopherol compared with other forms. alpha-Tocopherol transfer protein (alpha-TTP) is a liver cytosolic protein, which specifically binds alpha-tocopherol, and plays an important role in the discrimination of various tocopherols in the body. Furthermore, alpha-TTP is a product of the causative gene for familial isolated vitamin E deficiency. Using cell culture system, it was shown that alpha-TTP functions to enhance secretion of alpha-tocopherol from liver cells and that the reaction utilizes a novel non-Golgi mediated pathway which may be linked to cellular cholesterol metabolism and/or transport.
    Nippon rinsho. Japanese journal of clinical medicine 11/1999; 57(10):2276-83.


  • 1999
    • The University of Tokyo
      • Faculty and Graduate School of Pharmaceutical Sciences
      Tokyo, Tokyo-to, Japan