G Cornélissen

University of Minnesota Duluth, Duluth, Minnesota, United States

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Publications (174)204.64 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: The circadian rhythm, as part of a broad time structure (chronome) of lipid peroxides and antioxidant defense mechanisms may relate to prevention, efficacy and management of preventive and curative chronotherapy. Methods: Fifty newly diagnosed patients with peptic ulcers, 30-45years of age, and 60 age-matched clinically healthy volunteers were synchronized for one week with diurnal activity from about 06:00 to about 22:00 and nocturnal rest. Breakfast was served around 08:30, lunch around 13:30 and dinner around 20:30. Drugs known to affect the free-radical systems were not taken. Blood samples were collected at 6-hour intervals for 24h under standardized, presumably 24-hour synchronized conditions. Plasma lipid peroxides, in the form of malondialdehyde (MDA), blood superoxide dismutase (SOD), glutathione peroxide (GPx), glutathione reductase (GR), catalase (CAT) activities, and serum total protein, albumin, ascorbic acid, total serum cholesterol, and HDL-cholesterol concentrations were determined. Results: By population-mean cosinor analysis, a marked circadian variation was demonstrated for all variables in healthy subjects and in ulcer patients (p<0.001). As compared to controls, patients had a lower MESOR of MDA, SOD, GPx, GR, ascorbic acid, and HDL-C. They also had smaller circadian amplitude of SOD, CAT, GPx, GR, ascorbic acid, T-C, and HDL-C, but larger circadian amplitude of MDA and albumin. As compared to healthy subjects, the circadian acrophase of ulcer patients occurred later for MDA and GR and earlier for GPx. Conclusion: Mapping circadian rhythms, important chronome components that include trends with age and extra-circadian components characterizing antioxidants and pro-oxidants, is needed for exploring their putative role as markers in the treatment and management of peptic ulcers.
    Clinica chimica acta; international journal of clinical chemistry 10/2015; 451(Pt B). DOI:10.1016/j.cca.2015.09.033 · 2.82 Impact Factor
  • Ranjana Singh · Sumita Sharma · Raj K. Singh · Germaine Cornelissen ·

    Indian Journal of Clinical Biochemistry 09/2015; DOI:10.1007/s12291-015-0519-8

  • Journal of the American Geriatrics Society 05/2015; 63(5):1031-3. DOI:10.1111/jgs.13426 · 4.57 Impact Factor
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    ABSTRACT: The effect of mild depression on blood pressure (BP) was assessed in 116 Japanese (32–79 years). As compared to non-depressive (Geriatric Depression Scale, GDS-15 score <5) subjects, mild depressives (GDS-15 score: 1–15) had shorter sleep duration (p = 0.021), lower subjective quality of life (health: p = 0.016; life satisfaction: p < 0.001; and happiness: p < 0.001), and higher 7-d systolic BP (p < 0.05). “Masked non-dipping” (dipping on day 1, but non-dipping on at least 1 of the following 6 d) was more frequent among depressive than non-depressive normotensives (p = 0.008). Among-day BP variability may underlie cardiovascular disease accompanying a key component of psychological depression.
    Clinical and Experimental Hypertension 03/2015; 37(5). DOI:10.3109/10641963.2015.1013114 · 1.23 Impact Factor
  • Shuting Cheng · Zhou Jiang · Zhengrong Wang · Germaine Cornelissen ·
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    ABSTRACT: Circadian clocks in organisms drive physiology and behavior, helping with adjustment to earth’s environment and human society. The generation and regulation mechanisms of circadian rhythms are starting to be understood. The transcriptional/post-transcriptional delayed feedback loop has been widely studied as the main regulational mechanism. But it cannot fully account for all circadian rhythms in cells. It has been reported that the ‘proto-clock’ may have been a cytosolic metabolic oscillation, and that the transcriptional translational regulation system, which provides robustness and amplifies circadian outputs, was developed during evolution. Research on circadian rhythms in cyanobacteria Synechococcus elongatus, algae Ostreococcus tauri and human red blood cells in the absence of transcription and translation indicates the existence of a non-transcriptional/translational regulation mechanism, in addition to the classical transcriptional/translational regulation mechanism. It revealed a close link between the two regulation systems of circadian rhythms, in which they might complement each other. And NAD, involved in energy metabolism, may be involved in their interaction.
    Biological Rhythm Research 03/2015; 46(4):1-11. DOI:10.1080/09291016.2015.1020203 · 0.92 Impact Factor
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    ABSTRACT: The aim of this study is to determine the patterns of mortality from cardiac-cerebral vascular disease (CCVD) and how they relate to cosmophysical factors over a six-year span. The daily number of deaths recorded in Chengdu over 2192 consecutive days (2007–2012), together with several factors related to solar activity (SA), geomagnetic activity (GMA), and the interplanetary magnetic field, were analyzed by the extended cosinor to estimate the parameters of major cycles characterizing each variable. Estimates of their respective periods with a measure of uncertainty serve to find coperiodisms (i.e. shared rhythms). The results show that mortality of cardiovascular diseases (CVD) and CCVD on days of GMA in quiet level was relatively higher on days of GMA in unsettled level. Whereas mortality data are characterized by a one-year synchronized component, most GMA and SA indices have periods differing from precisely one year. A half-year cycle is shared by almost all SA, GMA, and mortality variables with 95% confidence interval of the period covering 0.5 year. A transyear cycle (about 1.3 years) is found for all mortality data and many of the environmental variables. A cis-half-year (about 0.43 year) is shared between mortality from CCVD and flow pressure, sunspot numbers and storm-time variation. These results suggest the presence of complex temporal relations between patterns of CCVD mortality and cosmophysical activity.
    Biological Rhythm Research 12/2014; 45(4). DOI:10.1080/09291016.2013.876189 · 0.92 Impact Factor
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    G A Tóth · Cs Suskovics · B L Buda · G Cornélissen ·
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    ABSTRACT: Growth and maturation of children is a dynamic and complex biological process, influenced both by genetic and environmental factors. Children’s growth pattern can change from time to time; therefore, it is necessary to investigate the state of children’s somatic development repeatedly. According to a widely accepted and scientifically proven theory, children’s growth and maturation status is a fine indicator of the nutritional and health conditions of the general population. In other words, information about growth and development of children and youth mirrors the biological status and/or welfare of a population. The “Körmend Growth Study”, a chain of repeated cross-sectional growth studies performed on children in the town of Körmend (Hungary) was one of the first realizations of this principle. Anthropological investigations have been performed in Körmend in every 10 years since 1958 in a systematic way. The data are prepared from groups of 1563 to 2867 boys in Körmend, between 1958 and 2008 at 10-year intervals. Body Mass Index (BMI) was introduced into the human biology practice for the statistical evaluation of nutritional status according to the suggestions of Keys and coworkers. Comparing distinct ten-year intervals from 1958 to 2008, a characteristic tendency of BMI can be observed in boys.
    The 9th International Network of Sport and Health Science Conference “Qualitative and Quantitative Research in Sport Science”, Szombathely, Hungary; 12/2014

  • Journal of the American Geriatrics Society 08/2014; 62(8). DOI:10.1111/jgs.12963 · 4.57 Impact Factor
  • Kuniaki Otsuka · Kiyotaka Okajima · Takashi Yamanaka · Germaine Cornelissen ·
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    ABSTRACT: Analytical global and local methods applied to human blood pressure (BP) records of around-the-clock measurements. The chronobiological interpretation of ambulatory BP monitoring records in the light of time-specified reference values derived from healthy peers matched by sex and age identify vascular variability disorders (VVDs) for an assessment of cardio-, cerebro-, and renovascular disease risk. VVD includes circadian BP over-swinging (CHAT, short for circadian hyper-amplitude tension), deficient heart rate variability, MESOR (midline-estimating statistic of rhythm) hypertension, excessively elevated pulse pressure over 60 mmHg, BP ecphasia (an odd timing of the circadian rhythms in BP but not in that of heart rate) and frequency alteration. The term MESOR-hypertension indicates only one of several VVDs that can combine to for sets of 2, 3 and n-component vascular variability syndromes.
    Nippon rinsho. Japanese journal of clinical medicine 08/2014; 72(8):1491-6.
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    ABSTRACT: This work aims at studying in children the prevalence of some vascular variability anomalies (VVAs), i.e. indices of an increased risk of heart and vessel diseases revealed by chronobiologic analysis of cardiovascular monitoring data – systolic (SBP) and diastolic (DBP) MESOR-hypertension/hypotension, circadian hyper-amplitude-tension (CHAT), ecphasia and an excessive pulse pressure (EPP). A reference group of 138 healthy Moscow schoolchildren (age 12–17 years) was used for determination of 90% prediction limits for the circadian parameters of SBP and DBP, specified by gender and age (or height). The test group included another 194 children of the same age range with headache and abnormal BP values by casual measurement. BP data series from each child were analyzed by the COSINOR method. VVAs were found in 44.8% of children from the test group. In boys, VVAs occur more often than in girls (51.5% vs. 30.6%). One child may have up to 3 VVAs. The presence of VVAs may be related to an elevated BMI. The most common VVAs in childhood are the abnormalities of PP and systolic CHAT. Cosinor analysis can reveal a large number of children with PP higher than a threshold (60 mmHg) during a relatively long portion of the day (more than 1/3 of the 24 h span).
    Journal of applied biomedicine 07/2014; 12(3). DOI:10.1016/j.jab.2014.02.004 · 1.30 Impact Factor

  • Journal of the American Geriatrics Society 05/2014; 62(5):974-6. DOI:10.1111/jgs.12809 · 4.57 Impact Factor
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    Germaine Cornelissen ·
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    ABSTRACT: A brief overview is provided of cosinor-based techniques for the analysis of time series in chronobiology. Conceived as a regression problem, the method is applicable to non-equidistant data, a major advantage. Another dividend is the feasibility of deriving confidence intervals for parameters of rhythmic components of known periods, readily drawn from the least squares procedure, stressing the importance of prior (external) information. Originally developed for the analysis of short and sparse data series, the extended cosinor has been further developed for the analysis of long time series, focusing both on rhythm detection and parameter estimation. Attention is given to the assumptions underlying the use of the cosinor and ways to determine whether they are satisfied. In particular, ways of dealing with non-stationary data are presented. Examples illustrate the use of the different cosinor-based methods, extending their application from the study of circadian rhythms to the mapping of broad time structures (chronomes).
    Theoretical Biology and Medical Modelling 04/2014; 11(1):16. DOI:10.1186/1742-4682-11-16 · 0.95 Impact Factor

  • Journal of the American Geriatrics Society 03/2014; 62(3). DOI:10.1111/jgs.12721 · 4.57 Impact Factor
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    Nutrition 01/2014; 30(9). DOI:10.1016/j.nut.2013.12.013 · 2.93 Impact Factor
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    ABSTRACT: Background: Gender differences characterize cardiovascular adaptation to high altitude as a halting step toward a spatially (and temporally) "glocal" assessment of cardiovascular function. Spatially glocal differences were previously found in the incidence pattern of sudden cardiac death in different states of the USA and worldwide in Tokyo vs. the Republic of Georgia and Latvia, among others, and were found to change with time in the Czech Republic, documenting the need for glocality in examination in both time and space. A glocal examination of records by the analysis of time series as a whole (globally) and in sections systematically varied in length (locally in time) remains to be initiated in both the circadian and extracircadian domains at high and low altitudes on a larger scale. Human populations adjust to ambient hypoxia via changes in the expression of hypoxia-related genes. In this study, we examine the gender differences in adaptation to high altitude among Indian and Japanese subjects. Methods: We assessed, glocally (globally, to start with in India at high altitude and locally in Japan, in space but not yet glocally in time series), 1,858 Ladakhis (777 men and 1,081 women, aged from 13 to 92 years, average 51.4 years) and 25,211 Japanese (13,366 men and 11,845 women, aged from 16 to 98 years, average 48.0 years).We used validated questionnaires and clinical examination to assess the cardiovascular, autonomic and cognitive functions, at high altitude in Ladakh, India and at low altitude in Japan, comparing men and women in 3 groups living in Ladakh at different altitudes, i.e., from 2,500 to 3,000 meters (m), from 3,200 to 3,720 m, and from 3,800 to 4,590 m above sea level. Aortic stiffness was measured by finding out the cardio-ankle vascular index (CAVI) by the measurements of BP in the right and left forearms and ankles using a VaSera instrument (Fukuda Denshi, Tokyo). Results: As compared to Japanese living at low altitude, highland people in India showed higher values of aortic stiffness of the cardio-ankle vascular index (CAVI) in both men and women. Differences in altitude did not statistically significantly influence BP, pulse oximetry (SpO2), CAVI, and ECG findings in Ladakhi men. By contrast, CAVI values and BP in sitting position increased with statistical significance with increasing altitude in Ladakhi women. Incidences of first degree AV block, ST depression and abnormal Q waves in the ECG were more frequent at higher altitude in Ladakhi women. The change of SpO2 and diastolic BP over the years were more pronounced in Ladakhi women than in Ladakhi men. Conclusion: Without extrapolating beyond the time and geographic site investigated, women in Ladakh, India, were found to be more sensitive to hypoxia than men who appear to be better adapted.
    New research in cardiovascular health., 01/2014: chapter Chronoecological "Glocal" (Global and Local) Health-Watch: Men Better Adapted to Ambient Hypoxia than Women; Nova Sciences Publishers Inc. New York.
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  • Cardiovascular health and chronomics, Edited by Ram B Singh, 01/2014: chapter In Memoriam, Salvador Sanchez Alfonso De La Pena, MD, PhD: A Comrade in the Chronousphere (November 14, 1948 - November 2, 2011); Nova Science Publishers, Inc, New York., ISBN: 978-1-63117-027-0
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    ABSTRACT: On June 9, 2013, a legend, a maverick, a great scientist, an exceptional human being, highly esteemed author of Folia Anthropologica left us. Many of us, just like his close associates, also lost a dynamo, an inspiration, and a truly great paternal friend. He will be remembered for founding the fields of chronobiology, chronomics and chronobioethics. His accomplishments are summarized in his over 3,400 scientific publications. Some of our Editorial Board, just like many worldwide indeed call him their mentor and turned to him for advice, from study design and data analysis to the interpretation of results in the time dimension. His close colleagues called him Father Time, and colleagues in Russia and Azerbaijan honored him as Lord of Time. Franz coined the term circadian, after documenting that biologic rhythms tip the scale between health and disease and even between life and death. He went on to demonstrate that many other built-in cycles resonate in part with their counterparts in our broad environment. He strived to understand how to enhance positive thoughts and emotions as a scaffold for tolerance and love by seeking optimal configurations of the time structured realm of the mind, what he called the chronousphere. He was a scholar in the true sense of the word, combining science, philosophy, poetry, and spirituality. With applications in all fields of medicine and biology, Franz’s legacy is far-reaching. He will be remembered for showing that timing cancer treatment according to marker rhythms improves outcomes both in terms of heightened efficacy and lesser undesired side effects. His work earned him numerous awards, apart from holding professorships in Laboratory Medicine and Pathology, Physiology, Biology, Bioengineering, and Oral Medicine at the University of Minnesota. He was a honorary member of the Romanian Academies of Science and Medical Sciences and received honorary doctorates from the University of Montpellier (France), Ferrara (Italy), Tyumen (Siberia), Brno (Czech Republic), L’Aquila (Italy), and People's Friendship University of Russia (Moscow, Russia). Franz was also an elected member of the prestigious Leibniz Society and of the International Academy of Science. His achievements in the new field of chronomics earned him the O.Yu. Schmidt Medal and diploma for outstanding merits in development of geophysics, the first such award given to a non-physicist. The chains of Time have now been plucked asunder by him, and the fetters broken in pieces. We shall all miss him deeply. Rest in peace, Franz!
  • Germaine Cornelissen · Francine Halberg · Julia Halberg · Othild Schwartzkopff ·

    Journal of applied biomedicine 12/2013; 11(4):251. DOI:10.1016/S1214-021X(14)60067-3 · 1.30 Impact Factor
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    ABSTRACT: In most of the guidelines by various agencies, a widespread belief exists that underlying usual blood pressure can alone account for all blood pressure related risk of vascular events and for the benefits of anti-hypertensive drugs. This view may not be correct because it does not consider total risk. Around-the-clock ambulatory blood pressure monitoring is necessary for at least 7 days to better assess risk related to blood pressure and blood pressure variability. Reference limits for blood pressure are currently based mostly on cohort studies and on controlled drug trials conducted among hypertensive patients. This must be changed. Using fixed limits for all adults 18 years and older (or in just 2 age groups) should be replaced by time-specified limits qualified by gender, age, and ethnicity, to be derived from clinically healthy populations, as done on too small a scale within the project on The BIOsphere and the COSmos (BIOCOS). This special paper highlights Vascular Variability Disorders (VVDs), which include, with MESOR-hypertension, Circadian Hyper-Amplitude- Tension (CHAT), ecphasia, ecfrequentia, excessive pulse pressure, excessive pulse pressure product, and a deficient heart rate variability. Anti-hypertensive drugs with their bioavailability as well as bioactivity have to be optimized by chronotherapy to improve benefit and reduce side effects, as documented by a great scientist and human being, Professor Franz Halberg, an exceptional, remarkable man, the father of chronobiology, who introduced the concepts of chronopharmacology and chronotherapy.
    World Heart Journal 01/2013; 6(1).

Publication Stats

1k Citations
204.64 Total Impact Points


  • 1-2015
    • University of Minnesota Duluth
      • • Medical School
      • • Laboratory Medicine and Pathology
      Duluth, Minnesota, United States
  • 2004
    • University of Arkansas - Fort Smith
      Fort Smith, Arkansas, United States
  • 1990-1999
    • Tokyo Women's Medical University
      • School of Medicine
      Edo, Tōkyō, Japan
    • Mayo Clinic - Rochester
      Rochester, Minnesota, United States
    • University of Maryland, Baltimore
      Baltimore, Maryland, United States
    • Point Loma Nazarene University
      San Diego, California, United States
  • 1997
    • Kyoto Daini Red Cross Hospital
      Kioto, Kyōto, Japan
  • 1996
    • Universiteit Utrecht
      • Faculty of Veterinary Medicine
      Utrecht, Provincie Utrecht, Netherlands
  • 1994
    • University of Vigo
      • Bioengineering and Chronobiology Laboratories
      Vigo, Galicia, Spain
  • 1992
    • Sichuan University
      • Biomedical Engineering Center
      Hua-yang, Sichuan, China
  • 1991
    • Academia Sinica
      • Institute of Physics
      T’ai-pei, Taipei, Taiwan
  • 1989
    • Martin Luther University of Halle-Wittenberg
      Halle-on-the-Saale, Saxony-Anhalt, Germany
    • Tokyo Junshin Women's College
      • Department of Medicine
      Edo, Tōkyō, Japan
  • 1986
    • Kyushu University
      • Division of Internal Medicine
      Hukuoka, Fukuoka, Japan