Francisco Cardoso

Federal University of Minas Gerais, Cidade de Minas, Minas Gerais, Brazil

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Publications (153)450.96 Total impact

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    Thiago Cardoso Vale, Francisco Cardoso
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    ABSTRACT: The original descriptions of chorea date from the Middle Ages, when an epidemic of ‘‘dancing mania’’ swept throughout Europe. The condition was initially considered a curse sent by a saint, but was named ‘‘Saint Vitus’s dance’’ because afflicted individuals were cured if they touched churches storing Saint Vitus’s relics.Paracelsus coined the term chorea Sancti Viti and recognized different forms of chorea (imaginativa, lasciva, and naturalis). In the 17th century, Thomas Sydenham provided an accurate description of what he termed chorea minor. He also described rheumatic fever but did not associate it with chorea. It was only in 1850 that See established a relationship between chorea and rheumatic disease. A connection with cardiac involvement was soon recognized and in 1866 Roger postulated that chorea, arthritis, and heart disease had a common cause. The last quarter of the 19th century is marked by the works of Jean-Martin Charcot, Silas Weir Mitchell, William Osler, and William Richard Gowers, all of paramount importance in the refinement of the definition of chorea, its causes, and differential diagnosis. In 1841, Charles Oscar Waters gave a concise account of a syndrome, likely to be Huntington’s disease (HD), later described further by George Huntington and named after him. In 1955, the Venezuelan physician Americo Negrette published a book describing communities in the State of Zulia in Venezuela, with unusual numbers of individuals with chorea. Negrette’s works culminated in the creation of the Venezuela project and the subsequent discovery of seminal findings in HD. We review the historical facts and outstanding physicians that mark both HD and Sydenham’s chorea’s history in various sections.
    06/2015; 5:1-6. DOI:10.7916/D8WM1C98
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    ABSTRACT: Objective Parkinsonian patients usually present speech impairment. The aim of this study was to verify the influence of levodopa and of the adapted Lee Silverman Vocal Treatment® method on prosodic parameters employed by parkinsonian patients. Method Ten patients with idiopathic Parkinson's disease using levodopa underwent recording of utterances produced in four stages: expressing attitudes of certainty and doubt and declarative and interrogative modalities. The sentences were recorded under the effect of levodopa (on), without the effect of levodopa (off); before and after speech therapy during the on and off periods. Results The speech therapy and its association with drug treatment promoted the improvement of prosodic parameters: increase of fundamental frequency measures, reduction of measures of duration and greater intensity. Conclusion The association of speech therapy to medication treatment is of great value in improving the communication of parkinsonian patients.
    Arquivos de Neuro-Psiquiatria 01/2015; 73(1):30-5. DOI:10.1590/0004-282X20140193 · 1.01 Impact Factor
  • Francisco Cardoso
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    ABSTRACT: Chorea is a movement disorder that results from the continuous and random flow of muscle contractions leading to a dance-like appearance. The aims of this article are to define chorea, discuss its underlying causes, and provide a video demonstration of a seven-step guide on how to examine a patient with this movement disorder. This guide helps the clinician to determine the clinical features, severity, and etiology of chorea.
    12/2014; 1(4). DOI:10.1002/mdc3.12107
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    ABSTRACT: Several genes have been mapped in families or in sporadic cases of dystonia. TOR1-A (DYT1) gene was linked to isolated dystonia. Objective To associate clinical information of patients with dystonia with the TOR1-A gene mutations. Method Eighty-eight patients with dystonia in cervical area (focal, segmental, multifocal and generalized) were recruited at Movement Disorders Clinic of Hospital de Clínicas of the Federal University of Paraná between June of 2008 and June of 2009. They were submitted to the clinical evaluation. DNA was extract from blood and submitted at analysis to TOR1-A mutations by PCR according standard protocols. Results Two patients had c.907GAGdel mutation on TOR1-A gene. These patients, with familial history of dystonia, started his symptoms by legs and had secondary generalization. Conclusion We can suggest that analysis for TOR1-A mutations should be performed only in patients with early onset, generalized and familial dystonia.
    Arquivos de Neuro-Psiquiatria 10/2014; 72(10):753-6. DOI:10.1590/0004-282X20140123 · 1.01 Impact Factor
  • Hélio Afonso Ghizoni Teive, Paulo Caramelli, Francisco Eduardo Costa Cardoso
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    ABSTRACT: The authors present a historical review of the neurological diseases related to the famous moviemaker Federico Fellini. There is an account of diseases depicted on his movies as well as his ischemic stroke and consequent neurological deficit - left spatial neglect.
    Arquivos de Neuro-Psiquiatria 09/2014; 72(9):735-737. DOI:10.1590/0004-282X20140088 · 1.01 Impact Factor
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    Thiago Cardoso Vale, Paulo Caramelli, Francisco Cardoso
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    ABSTRACT: To compare the clinical and radiological features of vascular parkinsonism (VP) and Parkinson's disease (PD).
    Journal of Neurology Neurosurgery & Psychiatry 07/2014; 86(5). DOI:10.1136/jnnp-2014-307867 · 5.58 Impact Factor
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    ABSTRACT: Phacomatosis pigmentokeratotica is characterized by the coexistence of nevus sebaceus, papular nevus spilus and associated neurologic abnormalities. We report a case of phacomatosis pigmentokeratotica in a 28-year-old male who presented with palmar-plantar dysesthesia and ipsilateral brain hemiatrophy. As a characteristic neuroimaging finding of the disorder, we found multiple hypointense lesions involving the ipsilateral hemisphere.
    Journal of Dermatological Case Reports 06/2014; 8(2):58-9. DOI:10.3315/jdcr.2014.1174
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    ABSTRACT: Objective: The aim of this study was to identify clinical differences between patients with dystonia patients without family history and with family history (sporadic). Background: Although several loci and some genes were descripted in the last years, the presence of mutations in these genes in cohorts of patients with dystonia is low. For example, the presence of THAP1 mutations in families with earlier “primary” dystonia is about 25%. Regardless the monogenic inheritance, familial cases have lower mean age at disease onset than sporadic patients. Spread of dystonia to at least a second body site occurs more frequently in familial cases than in sporadic. The spread of symptoms is directly related to the duration of illness either in sporadic or in familial cases, however, in sporadic cases the most relevant spread occurs during the first 10 years; in familial patients, instead, progressive spread of dystonia occurs throughout the disease course. Methods: Eighty-eight patients with dystonia in cervical area were recruited in Movement Disorders Clinic of Hospital de Clínicas of the Federal University of Paraná between June of 2008 and June of 2009. They were submitted to the clinical evaluation and compared in two groups, sporadic and familiar patients. Results: The age of onset of symptoms was later in patients with focal and segmental dystonia than in patients with generalized dystonia (p<0.001). The severity of symptoms was higher in patients with sporadic dystonia than in familial patients (p<0.01). Generalized cases were more severe in patients with a family history (p<0.01). Sporadic patients had higher levels of pain than familial cases (p<0.05). Conclusions: There were important differences between sporadic and familiar cases of dystonia.
    Movement Disorders 06/2014; 29(Suppl 1):1339. · 5.63 Impact Factor
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    ABSTRACT: Objective: The aim of this study was to associate clinical information of patients with dystonia with the TOR1-A gene mutations. Background: Over the past 20 years, several loci (from DYT1 to DYT25) have been mapped in families with pure forms of dystonia, dystonia plus other movement disorders, or in sporadic cases. TOR1-A (DYT1) was the first gene linked to primary dystonia. TOR1-A is transmitted in an autosomal dominant fashion with penetrance ranging from 30 to 40% and the onset of clinical features commonly occurs during childhood or adolescence. Patients with TOR1-A mutations (delE302/303) usually have the onset in a limb with rapid spread to generalized dystonia, with cranio-cervical sparing. However, the spectrum of dystonia produced by the TOR1-A GAG deletion is broad and severity may vary in patients even within siblings. Methods: Eighty-eight patients with dystonia in cervical area (focal, segmental, multifocal and generalized) were recruited at Movement Disorders Clinic of Hospital de Clínicas of the Federal University of Paraná between June of 2008 and June of 2009. They were submitted to the clinical evaluation. DNA was extract from blood and submitted at analysis to TOR1-A mutations by PCR according standard protocols. Results: Two patients had c.907GAGdel mutation on TOR1-A gene. These patients, with familial history of dystonia, started his symptoms by legs and had secondary. Conclusions: We can suggest that analysis for TOR1-A mutations should be performed only in patients with early onset, generalized and familial dystonia.
    Movement Disorders 06/2014; 29(Suppl 1):1338. · 5.63 Impact Factor
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    ABSTRACT: Objective: The aim of this study was to associate clinical information of patients with dystonia with the THAP1 gene mutations. Background: Over the past 20 years, several genes (from DYT1 to DYT25) have been mapped in patients with dystonia. THAP1 (DYT6), a gene linked to primary dystonia, is transmitted in an autosomal dominant fashion with penetrance ranging from 40 to 60% and the onset of clinical features commonly occurs during childhood or adolescence. Extensive mutation analyses of THAP1 gene in several groups revealed more than 50 mutations, mainly concentrated in the THAP domain. It is manifested with a segmental or generalized, and progressive dystonia that involves mostly upper limbs and cranial-cervical muscles. The phenotype is highly variable even within a single family ranging from unaffected carriers to generalized dystonia. Methods: Seventy-four patients with dystonia in cervical area, without mutations in DYT1 (TOR1-A) and other movement disorders, were recruited in Movement Disorders Clinic of Hospital de Clínicas of the Federal University of Paraná between June of 2008 and June of 2009. They were submitted to the clinical evaluation. DNA was extract from blood and submitted at analysis to THAP1 mutations by PCR according standard protocols. Results: Three patients had the novel p.Gln97X THAP1 nonsense mutation. One of them had no familial history of dystonia. This patient started his symptoms by arms and had secondary generalization. The other two patients were from the same family. The first one opened the symptoms at 18 years old by right arm keeping segmental dystonia. The second one had the p.Arg169Gln missense mutation plus. She started the symptoms at 6 years old and sprayed the dystonia for generalizations. Conclusions: We can suggest that analysis THAP1 can be performed in patients with dystonia regardless the distribution or the familial history.
    Movement Disorders 06/2014; 29(Suppl 1):1337. · 5.63 Impact Factor
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    ABSTRACT: Marcel Proust was one of the greatest French writers of all times. Since early in his life, Proust was interested in arts and particularly literature. He also demonstrated a great knowledge of medicine, particularly neurology. His father was a doctor, and contributed to neurology through studies on aphasia, stroke, hysteria, and neurasthenia. During his childhood, Proust had the first asthma attack, initially considered a manifestation of neurasthenia. Regarding his illness, Proust was in touch with several renowned neurologists, such as Brissaud, Babinski and Sollier, and other disciples of Charcot. Proust spent the last three years of his life mostly confined to his bedroom since his health had badly deteriorated. In one moment, Babinski was called, examined Proust and after leaving his bedroom, announced to his brother that Proust was practically dead. Few hours later, Proust developed vomica and died.
    Arquivos de Neuro-Psiquiatria 06/2014; 72(6):469-470. DOI:10.1590/0004-282X20140034 · 1.01 Impact Factor
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    ABSTRACT: Several genes associated with dystonia have been identified. A mutation in one of these, THAP1 (DYT6), is linked to isolated dystonia. The aim of this study was to assess the prevalence of THAP1 gene mutations and the clinical characteristics of patients with these mutations in a clinical population in Brazil. Seventy-four patients presenting with dystonia involving the cervical muscles and without mutations in the TOR1A (DYT1) gene or any other movement disorders were recruited at a movement disorders clinic between June 2008 and June 2009. All the patients underwent clinical examination and were screened for mutations of the THAP1 gene. Three patients had the novel p.Gln97Ter THAP1 nonsense mutation in heterozygosis. One of them had no family history of dystonia. Symptoms in this patient first appeared in his right arm, and the condition progressed to the generalized form. The other two patients belonged to the same family (cousins). Symptoms in the first patient started in her right arm at the age of 18 years and the condition progressed to the segmental form. The second patient, who carried the p.Arg169Gln missense mutation, developed dystonia in her left arm at the age of 6 years. The condition progressed to generalized dystonia. We conclude that THAP1 mutations are also a cause, albeit uncommon, of segmental and generalized dystonia in the Brazilian population.
    04/2014; 4:226. DOI:10.7916/D83776RC
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    ABSTRACT: OBJECTIVE:The aim of this study was to identify clinical differences between patients with dystonia patients without family history and with family history (sporadic).BACKGROUND:Cervical dystonia (CD) affects the musculature of the neck in a focal way or associated to other parts of the body. Regardless the monogenic inheritance, familial cases have lower mean age at disease onset than sporadic patients. Spread of dystonia to at least a second body site occurs more frequently in familial cases than in sporadic. The spread of symptoms is directly related to the duration of illness either in sporadic or in familial cases, however, in sporadic cases the most relevant spread occurs during the first 10 years; in familial patients, instead, progressive spread of dystonia occurs throughout the disease course.DESIGN/METHODS:Eighty-eight patients with CD were recruited in a Movement Disorders Clinic between June of 2008 and June of 2009. Only patients with no etiological diagnosis were accepted for analysis.RESULTS:The age of onset of symptoms was later in patients with focal and segmental dystonia than in patients with generalized dystonia (p<0.001). The severity of symptoms was higher in patients with sporadic dystonia than in familial patients (p<0.01). Generalized cases were more severe in patients with a family history (p<0.01). Sporadic patients had higher levels of pain than familial cases (p<0.05).CONCLUSIONS: We descripted different clinical features, severity of symptoms and pain, between familial and sporadic patients with CD. This study was part of a continuous project. We expect to present the results of genetic analyzes of these patients.Study Supported by:
    Neurology 04/2014; 82(10 Supplement):P2.041. · 8.30 Impact Factor
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    ABSTRACT: OBJECTIVE:The aim of this study was to associate clinical and genetic information of patients with CD with the DYT1 and DYT6 gene mutations.BACKGROUND: Cervical dystonia (CD) affects the musculature of the neck in a focal way or associated to other parts of the body.DESIGN/METHODS: Eighty-eight patients with CD were recruited in Botulinum Toxin Clinic and Movement Disorders Clinic of Hospital de Clínicas of the Federal University of Paraná between June of 2008 and June of 2009. They were submitted to the clinical evaluation. DNA was extract from blood and submitted at analysis to DYT1 and DYT6 mutations by PCR according standard protocols.RESULTS: Two patients, with familial and generalized dystonia, had c.907GAGdel mutation on DYT1 gene. Three patients had the novel p.Gln97X DYT6 gene nonsense mutation. One of them had no familial history of dystonia. This patient started his symptoms by arms at 22 years old, and had secondary generalization. The other two patients were from the same family. The first one opened the symptoms at 18 years old by right arm keeping segmental dystonia (cranial-cervical and arms). The second one had the p.Arg169Gln missense mutation plus. She started the symptoms at 6 years old and sprayed the dystonia for generalizations associated with speech disorders.CONCLUSIONS: We can sugest that analysis for DYT1 mutations in patients with CD should be performed in patients with generalized and familial dystonia. The DYT6 analysis can be performed in patients with CD regardless the distribution or the familial history.
    Neurology 04/2014; 82(10 Supplement):P2.041. · 8.30 Impact Factor
  • Hélio A G Teive, Renato P Munhoz, Francisco Cardoso
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    ABSTRACT: Marcel Proust is one of the most important French writers of the 20th century. His relationship with medicine and with neurology is possibly linked to the fact that his asthma was considered to be a psychosomatic disease classified as neurasthenia. Stendhal's syndrome is a rare psychiatric syndrome characterized by anxiety and affective and thought disturbances when a person is exposed to a work of art. Here, the authors describe neurological aspects of Proust's work, particularly the occurrence of Stendhal's syndrome and syncope when he as well as one of the characters of In Search of Lost Time see Vermeer's View of Delft during a visit to a museum. © 2014 S. Karger AG, Basel.
    European Neurology 03/2014; 71(5-6):296-298. DOI:10.1159/000357562 · 1.36 Impact Factor
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    Neurological Sciences 02/2014; 35(5). DOI:10.1007/s10072-014-1654-3 · 1.50 Impact Factor
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    ABSTRACT: Cervical dystonia (CD) affects the musculature of the neck in a focal way or associated to other parts of the body. The aim of this study was to identify clinical differences between patients with dystonia patients without family history and with family history (sporadic). Eighty-eight patients with CD were recruited in a Movement Disorders Clinic between June of 2008 and June of 2009. Only patients with no etiological diagnosis were accepted for analysis. The age of onset of symptoms was later in patients with focal and segmental dystonia than in patients with generalized dystonia (p<0.001). The severity of symptoms was higher in patients with sporadic dystonia than in familial patients (p<0.01). Generalized cases were more severe in patients with a family history (p<0.01). Sporadic patients had higher levels of pain than familial cases (p<0.05). We expect soon to present the results of genetic analyzes of these patients.
    Arquivos de neuro-psiquiatria 02/2014; 72(2):107-13. DOI:10.1590/0004-282X20130225 · 1.01 Impact Factor
  • Francisco Cardoso
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    ABSTRACT: SUMMARY Huntington's disease (HD), an autosomal-dominant illness caused by an expansion of the CAG repeats on the short arm of chromosome 4, is clinically characterized by a combination of movement disorders, cognitive decline and behavioral changes. HD accounts for 90-99% of patients who present with this clinical picture. The remaining patients that are negative for the HD genetic mutation are said to have HD phenocopies. Autosomal-dominant diseases that can mimic HD are HD-like 2, C9orf72 mutations, spinocerebellar ataxia type 2, spinocerebellar ataxia type 17 (HD-like 4), benign hereditary chorea, neuroferritinopathy (neurodegeneration with brain iron accumulation type 3), dentatorubropallidoluysian atrophy and HD-like 1. There are also autosomal-recessive choreas that can be HD phenocopies: Friedreich's ataxia, neuroacanthocytosis, several forms of neurodegeneration with brain iron accumulation, ataxia telangiectasia, HD-like 3 and ataxia with oculomotor apraxia. Among X‑linked conditions, McLeod syndrome can mimic the clinical features of HD. Although less frequently, sporadic conditions, such as tardive dyskinesia and non-Wilsonian hepatolenticular degeneration, can also mimic HD.
    02/2014; 4(1):67-72. DOI:10.2217/nmt.13.78
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    ABSTRACT: Sydenham's chorea, a major manifestation of rheumatic fever, is characterized by chorea, behavioral changes, and cognitive dysfunction. Perfusion changes in the basal ganglia are the most frequent imaging findings observed in patients with Sydenham's chorea. Twelve adult women with Sydenham's chorea in remission underwent brain single-photon emission computed tomography (SPECT). Their scans underwent a quantification process to evaluate the perfusion of Brodmann's areas of the frontal lobes and basal ganglia. The results were compared with the findings from a control group that was matched by age. A pattern of hyperperfusion in the left putamen was observed in the patient group (P = 0.02). No significant difference was observed in relation to other brain regions. The findings of brain SPECT suggest that perfusion abnormalities of the basal ganglia may persist even after the remission of abnormal movements in patients with Sydenham's chorea. © 2013 International Parkinson and Movement Disorder Society.
    Movement Disorders 02/2014; 29(2):256-8. DOI:10.1002/mds.25721 · 5.63 Impact Factor
  • Francisco Cardoso
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    ABSTRACT: The aim of this article is to review movement disorders in children. They are common but have etiology and phenomenology different than in adults. Tics are the most common phenomena although in most instances they are mild and have a favorable long-term prognosis. Dystonia is the second most common phenomena but when present it is usually genetic or idiopathic and causes meaningful disability. Sydenham's chorea is the most common cause of chorea in children worldwide. Systemic lupus erythematosus is a much rarer cause of chorea but it is always to be ruled out given the lack of a specific diagnostic marker for Sydenham's chorea. Tremor, usually caused by drugs or essential tremor, is regarded as rather uncommon in children. Arguably, most pediatric patients with tremor do not seek medical attention because of the lack of disability. Stereotypies are relatively uncommon but their recognition is clinically relevant since they are usually associated with severe conditions such as autism and Rett syndrome. Parkinsonism is quite rare in children and either results from encephalitis or is a side effect of medications. Wilson's disease must be ruled out in all children with movement disorders.
    Parkinsonism & Related Disorders 01/2014; 20S1:S13-S16. DOI:10.1016/S1353-8020(13)70006-3 · 4.13 Impact Factor

Publication Stats

1k Citations
450.96 Total Impact Points

Institutions

  • 1996–2015
    • Federal University of Minas Gerais
      • • Departamento de Clínica Médica
      • • Hospital das Clínicas
      • • Faculty of Medicine
      Cidade de Minas, Minas Gerais, Brazil
  • 2006
    • Hospital de Clínicas Niterói
      Vila Real da Praia Grande, Rio de Janeiro, Brazil
    • Fundação Hospitalar do Estado de Minas Gerais
      Cidade de Minas, Minas Gerais, Brazil