Zhongguo fei ai za zhi = Chinese journal of lung cancer 10/2008; 11(5):739-41. DOI:10.3779/j.issn.1009-3419.2008.05.006
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ABSTRACT: Objective: To investigate and evaluate improvement of lung cancer survival after surgical intervention in PUMC hospital during
the last 15 years. Methods: From January 1989 to December 2003, 1574 lung cancer cases underwent surgical treatment and followed
up. All cases in this series were divided into two groups according to time period: group A (1999–2003) and group B (1989–1998).
The difference in the survival rate between groups A and B was compared. Results: The morbidity and mortality in group A was
decreased significantly in comparison to group B (11.2% vs. 19.2%, 1.06% vs. 1.93%, respectively). However, the 3-year and
5-year survival rate was increased from 42.35% to 56.07%, and from 28.46% to 38.99%, respectively. A significant improvement
in survival was observed in patients with stage I, II and IIIA, but not in those with stage IIIB and IV. Also, patients with
lobectomy had more satisfactory results than those receiving exploratory thoracotomy, limited resection, pneumonectomy and
sleeve resection. Conclusion: Lobectomy plus systematic mediastinal lymph nodes dissection has become the standard mode for
resectable lung cancer. Combination of complete resection along with lymph nodal dissection, and postoperative adjuvant chemotherapy
based on platinum/3rd generation chemotherapy medicine, has preliminarily been justified, proving an important approach for effective improvement
in long-term survival of non-small cell lung carcinoma.
The Chinese-German Journal of Clinical Oncology 08/2006; 5(4):240-244. DOI:10.1007/s10330-006-0472-3
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ABSTRACT: Lung cancer is still the most common cause of cancer death. Although it is reported that the 5-year survival rate for lung cancer has been greatly increased, surgical results are controversial. The aim of this study is to investigate and evaluate the improvement of survival of lung cancer surgically intervened in PUMC hospital during the last 15 years.
From January 1989 to December 2003, 1574 cases of lung cancer underwent surgical treatment and obtained follow-up. The results were retrospectively a- nalysed . All cases in this series were divided into two groups according to time, group A (1999-2003) and group B (1989-1998), and the differences of survival rate between group A and group B were compared.
The morbidity and mortality of group A decreased significantly when compared to group B (11.2% vs 19.2%, 1.06% vs 1.93%, respectively, P < 0.01). However, the 3- and 5-year survival rates had been obviously raised from 42.35% to 56.07%, and from 28.46% to 38.99%, respectively (P < 0.05 ). A significant improvement in survival was observed in patients with stageI, stage II and stage IIIA, but not in stage IIIB and stage IV. Also, the patients with lobectomy had better results but those with exploratory thoracotomy, limited resection, pneumonectomy and sleeve resection did not show better results.
Lobectomy associated with systematic dissection of mediastinal lymph nodes has become the standard mode for the resectable lung cancer. Combination of complete resection and lymph nodes dissection, with postoperative adjuvant chemotherapy based on platinum/3rd generation medicine, have preliminarily been justified and proved an important approach for effective improvement of long-term survival of lung cancer.
Zhongguo fei ai za zhi = Chinese journal of lung cancer 04/2005; 8(2):124-8. DOI:10.3779/j.issn.1009-3419.2005.02.11