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ABSTRACT: The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s)
leads to the formation of five new organotin(IV) complexes: [MeSnCl2(PAPD)] (2),
[BuSnCl2(PAPD)] (3), [PhSnCl2(PAPD)] (4), [Me2SnCl(PAPD)] (5), and [Ph2SnCl(PAPD)]
(6). The ligand [HPAPD, (1)] and its organotin(IV) complexes (2–6) have been characterized by
CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies.
Spectroscopic data suggested that HPAPD is coordinated to tin(IV) through the carboxylato-O
and azomethine-N as a mononegative bidentate chelating agent; the coordination number
of tin is five. Compound 1 and its organotin(IV) complexes (2–6) were assayed for in vitro
antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenes,
Escherichia coli, and Salmonella typhi. The screening results show that 2–6 have better
antibacterial activity than 1 and that 6 exhibits significantly better activity than 2–5.
Journal of Coordination Chemistry 05/2012; 65:1999-2007. · 1.55 Impact Factor
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Journal of Organometallic Chemistry 01/2012; 696:4202-4206. · 2.38 Impact Factor
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ABSTRACT: Five new organotin(IV) complexes of 2-hydroxyacetophenone-2-methylphenylthiosemicarbazone [H(2)dampt, (1)] with formula [RSnCl(n-1)(dampt)] (where R = Me, n = 2 (2); R = Bu, n = 2 (3); R = Ph, n = 2 (4); R = Me(2), n = 1 (5); R = Ph(2), n = 1 (6)) have been synthesized by direct reaction of H(2)dampt (1) with organotin(IV) chloride(s) in absolute methanol. The ligand (1) and its organotin(IV) complexes (2-6) were characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, (1)H, (13)C, and (119)Sn NMR spectral studies. H(2)dampt (1) is newly synthesized and has been structurally characterized by X-ray crystallography. Spectroscopic data suggested that H(2)dampt (1) is coordinated to the tin(IV) atom through the thiolate-S, azomethine-N, and phenoxide-O atoms; the coordination number of tin is five. The in vitro antibacterial activity has been evaluated against Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli, and Salmonella typhi. The screening results have shown that the organotin(IV) complexes (2-6) have better antibacterial activities and have potential as drugs. Furthermore, it has been shown that diphenyltin(IV) derivative (6) exhibits significantly better activity than the other organotin(IV) derivatives (2-5).
Bioinorganic Chemistry and Applications 01/2012; 2012:698491. · 0.72 Impact Factor
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Inorganica Chimica Acta 01/2011; 366:227-232. · 1.85 Impact Factor
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Journal of Coordination Chemistry 01/2011; 64:2409-2418. · 1.55 Impact Factor
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Journal of Coordination Chemistry 01/2011; 64:4191-4200. · 1.55 Impact Factor