Feng Wang

Institute of Forensic Science under the Ministry of Justice P.R. China, Shanghai, Shanghai Shi, China

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Publications (53)162.18 Total impact

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    ABSTRACT: In this paper we present new zircon U–Pb ages, Hf isotope data, and whole-rock major and trace element data for Early Mesozoic intrusive rocks in the Erguna Massif of NE China, and we use these data to constrain the history of southwards subduction of the Mongol–Okhotsk oceanic plate, and its influence on NE China as a whole. The zircon U–Pb dating indicates that Early Mesozoic magmatic activity in the Erguna Massif can be subdivided into four stages at ~ 246 Ma, ~ 225 Ma, ~ 205 Ma, and ~ 185 Ma. The ~ 246 Ma intrusive rocks comprise a suite of high-K calc-alkaline diorites, quartz diorites, granodiorites, monzogranites, and syenogranites, with I-type affinities. The ~ 225 Ma intrusive rocks consist of gabbro–diorites and granitoids, and they constitute a bimodal igneous association. The ~ 205 Ma intrusive rocks are dominated by calc-alkaline I-type granitoids that are accompanied by subordinate intermediate–mafic rocks. The ~ 185 Ma intrusive rocks are dominated by I-type granitoids, accompanied by minor amounts of A-types. These Early Mesozoic granitoids mainly originated by partial melting of a depleted and heterogeneous lower crust, whereas the coeval mafic rocks were probably derived from partial melting of a depleted mantle modified by subduction-related fluids. The rock associations and their geochemical features indicate that the ~ 246 Ma, ~ 205 Ma, and ~ 185 Ma intrusive rocks formed in an active continental margin setting related to the southwards subduction of the Mongol–Okhotsk oceanic plate. The ~ 225 Ma bimodal igneous rock association formed within an extensional environment in a pause during the subduction process of the Mongol–Okhotsk oceanic plate. Every magmatic stage has its own corresponding set of porphyry deposits in the southeast of the Mongol–Okhotsk suture belt. Taking all this into account, we conclude the following: (1) during the Early Mesozoic, the Mongol–Okhotsk oceanic plate was subducted towards the south beneath the Erguna Massif, but with a pause in subduction at ~ 225 Ma; and (2) the southwards subduction of the Mongol–Okhotsk oceanic plate not only caused the intense magmatic activity, but was also favorable to the formation of porphyry deposits.
    Gondwana Research 02/2015; · 8.12 Impact Factor
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    ABSTRACT: The Mongol–Okhotsk suture belt played an important role in the tectonic evolution of northeast Asia during the Mesozoic. However, few studies have examined the influence of this tectonic belt on the geological evolution of northeast China. In this paper, we present zircon U–Pb geochronology, major and trace element geochemistry, and zircon Hf–O isotopic data for Early Jurassic volcanic rocks in the Erguna Massif of northeast China, with the aim of constraining the evolution of the Mongol–Okhotsk suture belt and its influence on the tectonic history of China during the Early Jurassic. Zircon U–Pb dating indicates that the trachybasalt and basaltic andesite in the study area were erupted between 193 ± 5 Ma and 181 ± 9 Ma (i.e., in the Early Jurassic). These Early Jurassic volcanic rocks belong to the high-K calc-alkaline series and are enriched in large ion lithophile elements and light rare earth elements, as well as being depleted in heavy rare earth elements and high field strength elements such as Nb and Ta. The rocks show a small negative Eu anomaly. The zircon εHf (182 Ma) values of the volcanic rocks range from -1.9 to + 5.1, corresponding to TDM1 values of 640–901 Ma and TDM2 values of 901–1345 Ma. Zircons from two volcanic rocks yield δ18O values of 7.2‰ ± 1.5‰ (n = 19) and 6.6‰ ± 0.7‰ (n = 35). Geochemically, these Early Jurassic volcanic rocks are similar to those from active continental margin settings, and their primary magmas could have been derived from the partial melting of a lithospheric mantle wedge modified by fluid from a subducted slab. The discovery of Early Jurassic calc-alkaline volcanic rocks in the Erguna Massif, together with the coeval porphyry Cu–Mo deposits, indicates that an active continental margin existed in the Erguna area during the Early Jurassic. Taken together, we conclude that southward subduction of the Mongol–Okhotsk oceanic plate took place beneath the Erguna Massif during the Early Jurassic.
    Lithos 01/2015; 218-219. · 3.65 Impact Factor
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    ABSTRACT: This case report describes an unusual presentation of Clonorchis sinensis infection. In this rare case, a clonorchiasis infection that had been latent for decades was misdiagnosed as acute calculous cholecystitis. Exploratory surgery and a cholecystectomy were performed. Therefore, in the course of diagnosis of hepatic and gall diseases, we cannot neglect parasite infections such as clonorchiasis.
    American Journal of Emergency Medicine 11/2014; · 1.15 Impact Factor
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    ABSTRACT: To investigate the antimicrobial activity of imipenem and rifampicin alone and in combination against clinical isolates of Acinetobacter baumannii grown in planktonic and biofilm cultures. Minimum inhibitory concentrations were determined for each isolate grown in suspension and in biofilm using a microbroth dilution method. Chequerboard assays and the agar disk diffusion assay were used to determine synergistic, indifferent or antagonistic interactions between imipenem and rifampicin. We used the tissue culture plate method for A. baumannii biofilm formation to measure the percentage of biofilm inhibition and the amount of extracellular DNA after the treatment. To understand the synergistic mechanisms, we conducted hydroxyl radical formation assays. The results were verified by confocal laser scanning microscopy. Imipenem and rifampicin showed effective antimicrobial activity against suspensions and biofilm cultures of A. baumannii, respectively. Synergistic antimicrobial effects between imipenem and rifampicin were observed in 13 and 17 of the 20 clinical isolates when in suspension and in biofilms, respectively. Imipenem and rifampicin alone and in combination generated hydroxyl radicals, which are highly reactive oxygen forms and the major components of bactericidal agents. Furthermore, treatment with imipenem and rifampicin individually or in combination has obvious antibiofilm effects. The synergistic activity of imipenem and rifampicin against clinical isolates of A. baumannii (in suspension and in biofilms) was observed in vitro. Therefore, we conclude that imipenem combined with rifampicin has the potential to be used as a combinatorial therapy for the treatment of infectious diseases caused by A. baumannii.
    World Journal of Microbiology and Biotechnology 10/2014; · 1.35 Impact Factor
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    ABSTRACT: Short tandem repeat (STR) genotyping methods are widely used for human identity testing applications, including forensic DNA analysis. Samples of DNA containing the length-variant STR alleles are typically separated and genotyped by comparison to an allelic ladder. Here, we describe a newly devised library of cloned STR alleles. The library covers alleles X and Y for the sex-determining locus Amelogenin and 259 other alleles for 22 autosomal STR loci (TPOX, D3S1358, FGA, D5S818, CSF1PO, D7S820, D8S1179, TH01, vWA, D13S317, D16S539, D18S51, D21S11, D2S1338, D6S1043, D12S391, Penta E, D19S433, D11S4463, D17S974, D3S4529 and D12ATA63). New primers were designed for all these loci to construct recombinant plasmids so that the library retains core repeat elements of STR as well as 50- and 30- flanking sequences of �500 base pairs. Since amplicons of commercial STR genotyping kits and systems developed in laboratories are usually distributed from 50 to <500 base pairs, this library could provide universal templates for allelic ladder preparation. We prepared three different sets of allelic ladders for this locus TH01 and an updated version of an allelic ladder for the DNATyper119 multiplex system using these plasmids to confirm the suitability of the library as a good source for allelic ladder preparation. Importantly, the authenticity of each construct was confirmed by bidirectional nucleotide sequencing and we report the repeat structures of the 259 STR alleles. The sequencing results showed all repeat structures we obtained for TPOX, CSF1PO, D7S820, TH01, D16S539, D18S51 and Penta E were the same as reported. However, we identified 102 unreported repeat structures from the other 15 STR loci, supplementing our current knowledge of repeat structures and leading to further understanding of these widely used loci.
    Forensic Science International: Genetics 09/2014; 12:136-143. · 3.86 Impact Factor
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    ABSTRACT: Deoxyribonuclease II (DNase II) is a well-known acidic endonuclease that catalyses the degradation of DNA into oligonucleotides. Only one or a few genes encoding DNase II have been observed in the genomes of many species. 125 DNase II-like protein family genes were predicted in the Trichinella spiralis (T. spiralis) genome; however, none have been confirmed. DNase II is a monomeric nuclease that contains two copies of a variant HKD motif in the N- and C-termini. Of these 125 genes, only plancitoxin-1 (1095 bp, GenBank accession no. XM_003370715.1) contains the HKD motif in its C-terminus domain.
    PLoS Neglected Tropical Diseases 08/2014; 8(8):e3097. · 4.49 Impact Factor
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    Gondwana Research 07/2014; 26(1):402–413. · 8.12 Impact Factor
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    ABSTRACT: The therapeutic methods for chronic hepatitis B are limited. The shortage of organ donors and hepatitis B virus (HBV) reinfection obstruct the clinical application of orthotopic liver transplantation (OLT). In the present study, adipose-derived mesenchymal stem cells (AD-MSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) were isolated from chronic hepatitis B patients and characterized for morphology, growth potency, surface phenotype and the differentiation potential. The results showed that both MSCs had adipogenic, osteogenic and neuron differentiation potential, and nearly all MSCs expressed CD105, CD44 and CD29. Compared with AD-MSCs, BM-MSCs of chronic hepatitis B patients proliferated defectively. In addition, the ability of AD-MSCs to differentiate into hepatocyte was evaluated and the susceptibility to HBV infection were assessed. AD-MSCs could differentiate into functional hepatocyte-like cells. These cells express the hepatic-specific markers and have glycogen production and albumin secretion function. AD-MSCs and hepatic differentiation AD-MSCs were not susceptible to infection by HBV in vitro. Compared with BM-MSCs, AD-MSCs may be alternative stem cells for chronic hepatitis B patients.
    International Journal of Molecular Sciences 04/2014; 15(4):6096-110. · 2.34 Impact Factor
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    ABSTRACT: The formation of extracellular traps (ETs) has recently been recognized as a novel defense mechanism in several types of innate immune cells. It has been suggested that these structures are toxic to microbes and contribute significantly to killing several pathogens. However, the role of ETs formed by macrophages (METs) in defense against microbes remains little known. In this study, we demonstrated that a subset of murine J774A.1 macrophage cell line (8% to 17%) and peritoneal macrophages (8.5% to 15%) form METs-like structures (METs-LS) in response to Escherichia coli and Candida albicans challenge. We found only a portion of murine METs-LS, which are released by dying macrophages, showed detectable killing effects on trapped E. coli but not C. albicans. Fluorescence and scanning electron microscopy analyses revealed that, in vitro, both microorganisms were entrapped in J774A.1 METs-LS composed of DNA and microbicidal proteins such as histone, myeloperoxidase and lysozyme. DNA components of both nucleus and mitochondrion origins were detectable in these structures. Additionally, METs-LS formation occurred independently of ROS produced by NADPH oxidase, and this process did not result in cell lysis. In summary, our results emphasized that microbes induced METs-LS in murine macrophage cells and that the microbicidal activity of these METs-LS differs greatly. We propose the function of METs-LS is to contain invading microbes at the infection site, thereby preventing the systemic diffusion of them, rather than significantly killing them.
    PLoS ONE 02/2014; 9(2):e90042. · 3.53 Impact Factor
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    International Geology Review 01/2014; 56(6):653-671. · 2.63 Impact Factor
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    ABSTRACT: In this paper, we present new zircon U–Pb dating, Hf isotope, major and trace elements, and Sr–Nd isotope data for Early–Middle Triassic intrusive rocks in the Erguna Massif of NE China, in the eastern segment of the Central Asian Orogenic Belt (CAOB). Our aim is to elucidate the tectonic evolution of the Mongol–Okhotsk Ocean and its influence on NE China. Zircons from five representative intrusions in the Erguna Massif are euhedral–subhedral in shape, display oscillatory growth zoning in CL images, and have Th/U ratios of 0.17–1.54, and in combination these features indicate that the zircons are of igneous origin. Zircon U–Pb dating results demonstrate that the Early–Middle Triassic magmatism in the Erguna Massif took place between 241 and 247 Ma. The Early–Middle Triassic rocks are composed mainly of a suite of diorites, quartz–diorites, granodiorites, monzogranites, and syenogranites. They have SiO2 = 57.71–72.86 wt.%, Mg# = 19–52, Al2O3 = 14.27–17.23 wt.%, and Na2O/K2O = 0.67–1.59. Chemically, they are metaluminous to peraluminous and belong to the high-K calc-alkaline series. Moreover, they are enriched in light rare earth elements and large ion lithophile elements, and depleted in heavy rare earth elements and high field strength elements (e.g., Nb, Ta, and Ti). The whole-rock εNd(t) and zircon εHf(t) values of these samples range from − 4.68 to − 3.42, and from − 2.0 to + 6.6, respectively, indicative of formation from primary magmas generated by partial melting of juvenile crustal material with a contribution from mantle-derived mafic magmas. These magmas subsequently underwent fractional crystallization, contamination, and magma mixing. Geochemically, these Early–Middle Triassic intrusive rocks have affinities with intrusive rocks from active continental margin settings. We conclude, therefore, that the Early–Middle Triassic magmatism in the Erguna Massif was generated within an active continental margin setting related to the southwards subduction of the Mongol–Okhotsk oceanic plate beneath the Erguna Massif. This conclusion is supported by the occurrence of Early Mesozoic porphyry and skarn deposits along the southeastern side of the Mongol–Okhotsk suture belt.
    Lithos 01/2014; s 184–187:1–16. · 3.65 Impact Factor
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    ABSTRACT: We here elucidate the tectonic evolution of the Xing’an and Songnen–Zhangguangcai Range massifs during the early Carboniferous–early Permian, based on zircon U–Pb dating and whole-rock geochemical analyses of volcanic rocks of the Songnen–Zhangguangcai Range Massif in the Sunwu area, Heilongjiang Province, NE China. Euhedral–subeuhedral zircons from three rhyolites and one dacite from the study area display fine-scale oscillatory growth zoning, indicating a magmatic origin. Zircon U–Pb dating by LA–ICP–MS indicates that these acidic volcanic rocks formed in the early Carboniferous–early Permian; i.e., early Carboniferous (~ 351 Ma), early late Carboniferous (~ 319 Ma), and early Permian (295–293 Ma). The early Carboniferous rhyolites exhibit chemical affinities to A-type rhyolites, implying an extensional environment. Their positive εHf(t) values (+ 8.67 to + 13.4 except for one spot of + 1.63) and Hf two-stage model ages (TDM2 = 562–988 Ma) indicate that the primary magma was possibly derived from partial melting of newly accreted continental crust. The early late Carboniferous rhyolites and dacites (~ 319 Ma) exhibit calc-alkaline peraluminous signatures [molar Al2O3/(CaO + K2O + Na2O) ratio, or A/CNK = 1.04–1.22)]. The εHf(t) values and TDM2 ages of zircons from the 319 Ma dacites are in the range of + 5.33 to + 9.32 and 907–1268 Ma, respectively, suggesting that the primary magma was derived from partial melting of newly accreted crust. The early Permian rhyolites (295–293 Ma) show chemical affinities to A-type rhyolites, implying an extensional tectonic environment; their positive εHf(t) values (+ 8.82 to + 13.8) and Hf two-stage model ages (484–743 Ma) indicate that the primary magma was derived from partial melting of newly accreted crust. Combined with the geochemical features of coeval igneous rocks from the eastern margin of the Xing’an Massif, these data reveal the late Paleozoic tectonic history and relationships of the Xing’an and Songnen–Zhangguangcai Range massifs, i.e., early Carboniferous westward subduction of the Paleo-Asian oceanic plate beneath the Xing’an Massif, followed by early late Carboniferous collision and amalgamation of microcontinental blocks, and early Permian post-collisional extension.
    Lithos 01/2014; · 3.65 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the immunoregulatory effects of hyperbaric oxygen (HBO) via promoting the apoptosis of peripheral blood lymphocytes (PBLs) to attenuate the severity of early stage acute pancreatitis (AP) in rats. Additionally, the persistence of the HBO treatment effects was evaluated. One hundred and twenty male Wistar rats were randomized into four groups: sham, AP, AP + normobaric oxygen (NBO), and AP + HBO. Each group consisted of 30 rats. Four hours after the induction of AP, the 30 rats in the AP + NBO group were given normobaric oxygen treatment with 100 % oxygen at 1 atm for 90 min. The 30 rats in the AP + HBO group received 100 % oxygen at 2.5 atm for 90 min, with a compression/decompression time of 15 min. The 30 rats in the AP group remained untreated. At 6, 12, and 24 h after the induction of AP, surviving rats from each group were sacrificed, and the blood and tissue samples were collected for the following measurements: the partial pressure of oxygen (PaO2) and oxygen saturation (SaO2) of the arterial blood, the levels of serum amylase, lipase, interleukin-2 (IL-2), interferon-γ (IFN-γ), interleukin-10 (IL-10), hepatocyte growth factor (HGF), and reactive oxygen species (ROS), and the mitochondrial membrane potential (∆Ψm) of the PBLs. The expression levels of procaspase-3, caspase-3, procaspase-9, and caspase-9 were also evaluated in the PBLs. Additionally, the apoptosis of PBLs was assessed, and the pancreatic tissues were subjected to a histopathological analysis by pathological grading and scoring. The histopathology of the lung, liver, kidney, duodenum, and heart was also analyzed at 12 h after the induction of AP. Significant differences were found at 6 and 12 h after AP induction. The HBO treatment significantly elevated the PaO2 and SaO2 levels, and the ROS levels in the PBLs. Additionally, HBO downregulated the levels of amylase and lipase. The HBO treatment also reduced the ∆Ψm levels, upregulated the expression of caspase-3 and caspase-9, and increased the apoptosis rate of the PBLs. Moreover, the HBO treatment decreased the serum concentrations of IL-2, IFN-γ and HGF, and reduced the pathological scores of the pancreatic tissue. The histopathological changes of the lung, liver, kidney, duodenum, and heart were also improved. A significant elevation of IL-10 occurred only at the 12-h time point. However, no obvious differences were found at the 24-h time point. This study demonstrated that the HBO treatment can promote the apoptosis of PBLs via a mitochondrial-dependent pathway and inhibit the inflammatory response. These immunoregulatory effects may play an important therapeutic role in attenuating the severity of early stage AP. The repeated administration of HBO or the use of HBO in combination with other approaches may further improve outcomes.
    Apoptosis 10/2013; · 3.61 Impact Factor
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    Journal of Asian Earth Sciences 10/2013; 76:12-29. · 2.83 Impact Factor
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    ABSTRACT: Abstract
    Journal of Asian Earth Sciences 09/2013; 74:167-193. · 2.83 Impact Factor
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    ABSTRACT: Deposition of extracellular matrix (ECM) in trabecular meshwork, such as fibronectin, collagen IV, elastin. leads to increased resistance of trabecular meshwork in primary open angle glaucoma (POAG). Connective tissue growth factor (CTGF) is known to regulate the ECM deposits. In this study, we detect the effect of adenovirus conducted CTGF (Adv-CTGF) transfection on either the expression of ECM components or aqueous humor outflow facility. Adv-CTGF was used to transfect rat trabecular meshwork cells in vivo and in vitro. Aqueous humor outflow facility was test by microbeads perfusion. Protein expression of CTGF, fibronectin, and collagen IV was determined using Western blot. In the Adv-CTGF group, the outflow facility displayed a significant decrease from baseline. It appears as though the transfection with Adv-CTGF significantly affects the aqueous humor outflow pattern. A negative correlation between IOP and PEFL indicated that a decrease in the area of bead deposition corresponded to an overall decrease of outflow, leading to an elevated IOP. Adv-CTGF can enhance the expression of CTGF, fibronectin and collagen IV. CTGF is the novel target for treatment of POAG. It is necessary to further study to test inhibition of CTGF expression for treatment of POAG.
    Molecular Biology Reports 09/2013; · 1.96 Impact Factor
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    Gondwana Research 09/2013; 24(2):635-647. · 8.12 Impact Factor
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    ABSTRACT: Zircon U-Pb dating and whole-rock geochemical analysis have been undertaken on Late Paleozoic-Early Mesozoic intrusive rocks of central Jilin Province, NE China, with the aim of constraining the tectonic evolution of the eastern segment of the northern margin of the North China Block (NCB) during the Late Paleozoic-Early Mesozoic. Zircon U-Pb dating indicates that Late Paleozoic-Early Mesozoic magmatic events can be subdivided into four stages: Middle Permian (~ 270 Ma), Late Permian (259-255 Ma), Early Triassic (~ 249 Ma), and Late Triassic (~ 222 Ma). The Middle Permian magmatic event formed peraluminous garnet-bearing monzogranites, indicative of formation under a compressional tectonic regime related to collision between the NCB and the Songnen-Zhangguangcai Range Massif. The Late Permian magmatic event formed gabbros and syenogranites, a bimodal association that is typical of magmatism within post-collisional extensional setting. The Early Triassic magmatic event formed adakitic monzogranites, suggesting that they formed from magmas derived from partial melting of a thickened mafic lower crust. The Late Triassic magmatic event formed a series of mafic-ultramafic intrusive rocks, together with coeval granitoids in adjacent regions, and make up a typical bimodal association suggesting that they formed under an extensional environment related to the final amalgamation of the NCB and the Songnen-Zhangguangcai Range Massif. Taken together, we conclude that the northern margin of the NCB underwent multiple orogenic events between the Middle Permian and the Late Triassic, with final amalgamation of the NCB and the Songnen-Zhangguangcai Range Massif occurring in the Early Triassic, an event that led to the final suturing of the Solonker-Xra Moron-Changchun zone.
    Lithos 06/2013; · 3.65 Impact Factor
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    ABSTRACT: In this paper, we discuss new zircon U–Pb ages, major and trace element analyses, and Hf isotope data for Neoproterozoic intrusive rocks in the Erguna Massif of NE China, in the eastern segment of the Central Asian Orogenic Belt (CAOB). Our aim is to elucidate the tectonic origin of the Erguna Massif and its relationship to the breakup of the Rodinia supercontinent. Zircons collected from a gabbro and five granitoids are euhedral–subhedral, and display striped absorption or fine-scale oscillatory growth zoning in CL images, implying a magmatic origin. Zircon U–Pb dating demonstrates that these rocks were emplaced in four stages during the Neoproterozoic, as follows: (1) ∼851 Ma, an intrusive suite of syenogranites; (2) ∼792 Ma, a bimodal igneous rock association of gabbros and gabbro–diorites, together with syenogranites; (3) ∼762 Ma, a suite of granodiorites; and (4) ∼737 Ma, another suite of syenogranites. These magmatic events are similar time-wise to those in the Tuva–Mongolia Massif and the northern Baikal region of the southern Siberian Craton, suggesting an affinity between the Erguna Massif and the southern margin of the Siberian Craton. The Neoproterozoic granitoids in the Erguna Massif have SiO2 = 68.72–78.36 wt.%, Mg# = 17–33, Al2O3 = 11.66–14.79 wt.%, (Na2O + K2O) = 7.46–9.27 wt.%, and A/CNK = 0.95–1.14; they are metaluminous to peraluminous, and similar to A-type granites. Moreover, these Neoproterozoic granitoids are enriched in light rare earth elements (LREEs) and large ion lithophile elements (LILEs), and depleted in heavy rare earth elements (HREEs) and high field strength elements (HFSEs, Nb, Ta, and Ti). Their zircon ɛHf (t) values mainly range from +2.7 to +8.1, which implies that their primary magmas were derived from partial melting of a depleted lower crust. In contrast, the Neoproterozoic gabbros and gabbro–diorites in the Erguna Massif have low SiO2 (50.43–51.53 wt.%), relatively high Mg# (46–51), high Ni (22.5–23.8 ppm), Cr (41.5–72.2 ppm), and Co contents (28.9–32.5 ppm), and are enriched in LILEs and LREEs but depleted in HREEs and HFSEs such as Nb and Ta. Their ɛHf (t) values range from +2.5 to +5.4. Together, these characteristics suggest the primary magmas of the gabbros and gabbro–diorites were derived by partial melting of a depleted mantle wedge that had been metasomatized by fluids derived from a subducted slab. In the context of the assembly and breakup of the Rodinia supercontinent, and Neoproterozoic magmatic events along the southern margin of the Siberian Craton, we conclude that the Neoproterozoic A-type granitoids, gabbros, and gabbro–diorites of the Erguna Massif formed in an extensional environment related to rifting, corresponding to the breakup of the Rodinia supercontinent.
    Precambrian Research 01/2013; 224:597–611. · 6.02 Impact Factor
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    ABSTRACT: Abstract Trichinellosis has major economic impacts on the animal husbandry and food safety, and the control and elimination of trichinellosis is a major objective of veterinary medicine. A gene encoding serine protease of Trichinella spiralis (T. spiralis) (Ts-Adsp) was identified by immunoscreening an adult T. spiralis cDNA library. In this study, the recombinant Ts-Adsp protein (rTs-Adsp) was cloned and expressed in a prokaryotic expression system and purified by Ni-affinity chromatography. To determine whether the purified rTs-Adsp is a potential vaccine candidate for the control of T. spiralis infection, we immunized BALB/c mice with this protein in combination with an alum adjuvant and subsequently challenged with T. spiralis larvae. The results showed that mice vaccinated with rTs-Adsp exhibited an average reduction in the muscle larvae burden of 46.5% relative to the control group. Immunization with the rTs-Adsp antigen induced both humoral and cellular immune responses, which manifested as elevated specific anti-rTs-Adsp IgG and IgE antibodies and a mixed Th1/Th2 response, as determined by Th1 (IFN-γ and IL-2) and Th2 (IL-4, IL-10 and IL-13) cytokine profiling, with the Th2 predominant. Thus, purified rTs-Adsp is able to limit the invasion of T. spiralis, and this protein could be an effective vaccine candidate for trichinellosis.
    Journal of Parasitology 12/2012; · 1.32 Impact Factor

Publication Stats

303 Citations
162.18 Total Impact Points

Institutions

  • 2014
    • Institute of Forensic Science under the Ministry of Justice P.R. China
      Shanghai, Shanghai Shi, China
  • 2010–2014
    • Jilin University
      • • College of Earth Sciences
      • • College of Animal Science and Veterinary Medicine
      Yung-chi, Jilin Sheng, China
  • 2009–2012
    • Northeast Institute of Geography and Agroecology
      • • Institute of Botany
      • • Laboratory of Photosynthesis and Environmental Biology
      Beijing, Beijing Shi, China
    • China Agricultural University
      • China State Key Laboratory of Plant Physiology and Biochemistry
      Peping, Beijing, China
  • 2006–2012
    • Chinese Academy of Sciences
      • • Laboratory of Plant Molecular Biology
      • • Laboratory of Photosynthesis and Environmental Biology
      • • Institute of Botany
      Peping, Beijing, China
  • 2010–2011
    • Weifang Medical University
      Wei, Shandong Sheng, China
  • 2006–2009
    • Harbin Medical University
      • Department of Ophthalmology
      Charbin, Heilongjiang Sheng, China