-
Revista Clínica Española 02/2009; 209(1):49-50. · 2.01 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: This report describes a 75-year-old Caucasian man with extensive urate deposits and severe gouty arthropathy that confined him to a wheelchair. Since age 50, he suffered multiple acute gout flares and progressive deformities in his hands, feet, knees, and elbows (tophi). Serum creatinine was 1.4 mg/dL and serum urate 9.4 mg/dL. Conditions known to increase uric acid production (psoriasis, chronic bronchitis) and to decrease uric acid excretion (hypothyroidism, metabolic syndrome, and nephroangiosclerosis) may operate in a single patient, illustrating the dramatic clinical course of untreated gout.
Nucleosides Nucleotides & Nucleic Acids 07/2008; 27(6):604-7. · 0.90 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: We studied the associations between serum urate levels (determined in 503 subjects from a population of 1,344 subjects living in northern Madrid) and both the metabolic syndrome (MS) (defined by the Adult Treatment Panel III criteria) and C-reactive protein (CRP, determined in 382 subjects). MS was diagnosed in 25% (95%CI, 21-28%) and was associated with hyperuricemia (p<0.001). There was a graded increase in serum urate levels with increasing number of MS components. Urate concentrations significantly correlated with waist circumference (r=0,455, p<0.01). Serum urate was not independently associated with CRP levels. This study shows that serum urate levels are associated with the presence of MS and each of its features.
Nucleosides Nucleotides & Nucleic Acids 06/2008; 27(6):620-3. · 0.90 Impact Factor
-
Revista Clínica Española 06/2008; 208(5):265. · 2.01 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Cerebral metastases from colorectal cancer occur in 8% of cases. Diagnosis is usually made when primary disease and widespread metastases are already known. However, the detection of brain metastases as the first sign of colorectal carcinoma without any liver and/or lung involvement is extremely rare. Central nervous system metastases are more commonly seen in rectal cancer and often occur concurrently with lung metastasis. We report a case of a patient with brain metastases as the first clinical manifestation of an adenocarcinoma of caecum without any other organ involvement.
Clinical and Translational Oncology 12/2007; 9(11):742-3. · 1.33 Impact Factor
-
Revista Clínica Española 10/2007; 207(8):403-4. · 2.01 Impact Factor