F Mauguière

French National Centre for Scientific Research, Lutetia Parisorum, Île-de-France, France

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Publications (407)1174.33 Total impact

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    ABSTRACT: We prospectively studied early bedside standard EEG characteristics in 61 acute postanoxic coma patients. Five simple EEG features, namely, isoelectric, discontinuous, nonreactive to intense auditory and nociceptive stimuli, dominant delta frequency, and occurrence of paroxysms were classified yes or no. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC) of each of these variables for predicting an unfavorable outcome, defined as death, persistent vegetative state, minimally conscious state, or severe neurological disability, as assessed 1 year after coma onset were computed as well as Synek's score. The outcome was unfavorable in 56 (91.8%) patients. Sensitivity, specificity, PPV, NPV, and AUC of nonreactive EEG for predicting an unfavorable outcome were 84%, 80%, 98%, 31%, and 0.82, respectively; and were all very close to the ones of Synek score >3, which were 82%, 80%, 98%, 29%, and 0.81, respectively. Specificities for predicting an unfavorable outcome were 100% for isoelectric, discontinuous, or dominant delta activity EEG. These 3 last features were constantly associated to unfavorable outcome. Absent EEG reactivity strongly predicted an unfavorable outcome in postanoxic coma, and performed as accurate as a Synek score >3. Analyzing characteristics of some simple EEG features may easily help nonneurophysiologist physicians to investigate prognostic issue of postanoxic coma patient. In this study (a) discontinuous, isoelectric, or delta-dominant EEG were constantly associated with unfavorable outcome and (b) nonreactive EEG performed prognostic as accurate as a Synek score >3.
    Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) 11/2015; DOI:10.1177/1550059415612375 · 2.22 Impact Factor

  • Neurology 09/2015; DOI:10.1212/WNL.0000000000002037 · 8.29 Impact Factor
  • Geneviève Demarquay · François Mauguière ·
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    ABSTRACT: Whereas considerable data have been generated about the pathophysiology of pain processing during migraine attacks, relatively little is known about the neural basis of sensory hypersensitivity. In migraine, the term "hypersensitivity" encompasses different and probably distinct pathophysiological aspects of sensory sensitivity. During attacks, many patients have enhanced sensitivity to visual, auditory and/or olfactory stimuli, which can enhance headache while interictally, migraineurs often report abnormal sensitivity to environmental stimuli that can cause nonpainful discomfort. In addition, sensorial stimuli can influence and trigger the onset of migraine attacks. The pathophysiological mechanisms and the origin of such sensitivity (individual predisposition to develop migraine disease or consequence of repeated migraine attacks) are ill understood. Functional neuroimaging and electrophysiological studies allow for noninvasive measures of neuronal responses to external stimuli and have contributed to our understanding of mechanisms underlying sensory hypersensitivity in migraine. The purpose of this review is to present pivotal neuroimaging and neurophysiological studies that explored the basal state of brain responsiveness to sensory stimuli in migraineurs, the alterations in habituation and attention to sensory inputs, the fluctuations of responsiveness to sensory stimuli before and during migraine attacks, and the relations between sensory hypersensitivity and clinical sensory complaints.
    Headache The Journal of Head and Face Pain 09/2015; DOI:10.1111/head.12651 · 2.71 Impact Factor
  • C. Czekala · F. Mauguière · S. Mazza · P.L. Jackson · M. Frot ·
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    ABSTRACT: Perspective: this study shows that pain facial expression can be processed subliminally after brief presentation times which might be helpful for critical emergency situations in clinical settings.
    The journal of pain: official journal of the American Pain Society 09/2015; DOI:10.1016/j.jpain.2015.09.006 · 4.01 Impact Factor
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    Irene Cristofori · Sylvain Harquel · Jean Isnard · François Mauguière · Angela Sirigu ·
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    ABSTRACT: Social pain after exclusion by others activates brain regions also involved in physical pain. Here we evaluated whether monetary reward could compensate for the negative feeling of social pain in the brain. To address this question we used the unique technique of intracranial electroencephalography in subjects with drug resistant epilepsy. Specifically, we recorded theta activity from intracranial electrodes implanted in the insular cortex while subjects experienced conditions of social inclusion and exclusion associated with monetary gain and loss. Our study confirmed that theta rhythm in the insular cortex is the neural signature of social exclusion. We found that while a monetary gain suppresses the effect of social pain in the anterior insula, there is no such effect in the posterior insula. These results imply that the anterior insula can use secondary reward signals to compensate for the negative feeling of social pain. HENCE, HERE WE PROPOSE THAT THE ANTERIOR INSULA PLAYS A PIVOTAL ROLE IN INTEGRATING CONTINGENCIES TO UPDATE SOCIAL PAIN FEELINGS: Finally, the possibility to modulate the theta rhythm through the reward system might open new avenues of research for treating pathologies related to social exclusion. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.
    Social Cognitive and Affective Neuroscience 05/2015; DOI:10.1093/scan/nsv054 · 7.37 Impact Factor
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    F Mauguière · I Merlet · N Forss · S Vanni · V Jousmäki · P Adeleine · R Hari ·

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    F Mauguière · I Merlet · N Forss · S Vanni · V Jousmäki · P Adeleine · R Hari ·

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    [Show description] [Hide description]
    DESCRIPTION: accepté pour publication (NCCN) Summary Somatosensory evoked potentials (SSEPs) are increasingly performed for the assessment of peripheral neuropathies, but no practical guidelines have been established in this specific application. For this purpose, a survey was conducted among the French-speaking practitioners having an experience of SSEP recording in the context of peripheral neuropathies. The objectives were to determine the relevant indication criteria and technical settings for SSEP recording in this condition. From this survey, SSEPs appeared to be a second-line test when electroneuromyographic investigation was not enough conclusive, providing complementary and valuable information on peripheral proximal conduction and central conduction in the somatosensory pathways. Guidelines for a standardized recording protocol, including the various variables to measure, are proposed. This consensus statement is an important step in the process to recognize the value of this technique in assessing peripheral neuropathies in clinical practice. Keywords: diagnosis; evoked potentials; indication; parameters; peripheral neuropathies; technique.
  • Perrine Devic · Philippe Petiot · François Mauguière ·
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    ABSTRACT: Diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) remains uncertain when nerve conduction studies (NCS) fail to show demyelination. We conducted a retrospective study of patients who presented with clinical criteria of CIDP in whom electrodiagnostic (EDX) criteria of definite or probable CIDP were missing [axonal sensory-motor neuropathy (n=23), normal EDX with pure sensory presentation (n=3)]. All patients received immunomodulatory treatment. Twenty-six patients were evaluated with somatosensory evoked potentials (SSEPs), MRI of spinal roots, CSF analysis, and/or nerve biopsy. Diagnosis of CIDP was considered to be confirmed in patients who responded to immunotherapy. 22 of 26 patients (85%) had SSEPs reflecting abnormal proximal conduction in sensory fibers, including 14 who had only clinical and SSEP data in favor of CIDP. SSEPs were abnormal in 16 of 20 responders (80%) to immunotherapy. SSEP recording contributes to diagnosis of CIDP when NCS fail to detect peripheral demyelination. This article is protected by copyright. All rights reserved. © 2015 Wiley Periodicals, Inc.
    Muscle & Nerve 04/2015; DOI:10.1002/mus.24693 · 2.28 Impact Factor
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    ABSTRACT: Radiofrequency thermocoagulation (RFTC) guided by stereoelectroencephalography (SEEG) has proved to be a safe palliative method to reduce seizure frequency in patients with drug-resistant partial epilepsy. In malformation of cortical development (MCD), increasing the number of implanted electrodes over that needed for mapping of the epileptogenic zone could help to maximize RFTC efficiency. To evaluate the benefit of SEEG-guided RFTC in 14 patients suffering from drug-resistant epilepsy related to MCD located in functional cortical areas or in regions poorly accessible to surgery. Ten men and 4 women were treated by RFTC. Thermolesions were produced by applying a 50-V, 120-mA current for 10 to 30 seconds within the epileptogenic zone as identified by the SEEG investigation. An average of 25.8 ± 17.5 thermolesions were made per procedure. The median follow-up after the procedure was 41.7 months. Sixty-four percent of the patients experienced a long-term decrease in seizure frequency of >50%, of whom 6 (43%) presented long-lasting freedom from seizure. When a focal low-voltage fast activity was present at seizure onset on SEEG recordings, 87.5% of patients were responders or seizure free. All of the patients in whom electric stimulation reproduced spontaneous seizures were responders. Our results show the good benefit-risk ratio of the SEEG-guided procedure for patients suffering from MCD in whom surgery is risky. This study identifies 2 factors, focal low-voltage, high-frequency activity at seizure onset and lowered epileptogenic threshold in the coagulated area, that could be predictive of a favorable seizure outcome after RFTC. LVFA, low-voltage fast activityMCD, malformation of cortical developmentRFTC, radiofrequency thermocoagulationSEEG, stereoelectroencephalography.
    Neurosurgery 03/2015; 77(1):1. DOI:10.1227/NEU.0000000000000723 · 3.62 Impact Factor
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    ABSTRACT: To explore whether painful somatosensory seizures (PSS) are generated in the primary somatosensory cortex (SI area) or in the operculo-insular cortex. We analyzed ictal recordings and data from stimulation using intracerebral electrodes exploring the operculo-insular cortex (including secondary somatosensory [SII] region), SI area, and other areas of the pain matrix (cingulate gyrus and supplementary motor area) in a case series study of 5 patients with PSS. Clinical features of PSS were different from those of seizures arising from the SI area: (1) pain intensity was higher; (2) pain spreading was not from one somatotopic territory to adjacent ones; and (3) the spatial extent of pain was large, fitting better with the size of somatosensory receptive fields of the insula and SII region than of the SI area. The insula and SII region were systematically involved at the onset of seizures, rapidly followed by the opercular portion of SI area. The upper part of SI cortex was involved at a lesser degree, with some delay, and pain duration did not correlate in time with that of the discharge in SI. Ictal pain was consistently reproduced by stimulation of the insula or SII region but never by stimulating the SI area. These data strongly suggest that PSS originate in the operculo-insular cortex and not in the SI area and corroborate the concept that this region is involved in the sensory-discriminative processing of pain inputs. Pain at the onset of PSS has a high value for localizing the epileptogenic area. © 2015 American Academy of Neurology.
    Neurology 01/2015; 84(6). DOI:10.1212/WNL.0000000000001235 · 8.29 Impact Factor
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    F Mauguière · I Merlet · N Forss · S Vanni · V Jousmäki · P Adeleine · R Hari ·

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    J. Yankam Njiwa · K.R. Gray · N. Costes · F. Mauguiere · P. Ryvlin · A. Hammers ·
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    ABSTRACT: We have previously shown that an imaging marker, increased periventricular [11C]flumazenil ([11C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS). Here, we investigated whether increased preoperative periventricular white matter (WM) signal can be detected on clinical [18F]FDG-PET images. We then explored the potential of periventricular FDG WM increases, as well as whole-brain [11C]FMZ and [18F]FDG images analysed with random forest classifiers, for predicting surgery outcome.
    Clinical neuroimaging 11/2014; 7. DOI:10.1016/j.nicl.2014.11.013 · 2.53 Impact Factor
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    Maud Frot · Isabelle Faillenot · François Mauguière ·
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    ABSTRACT: Previous brain imaging studies have shown robust activations in the insula during nociceptive stimulation. Most activations involve the posterior insular cortex but they can cover all insular gyri in some fMRI studies. However, little is known about the timing of activations across the different insular sub-regions. We report on the distribution of intracerebrally recorded nociceptive laser evoked potentials (LEPs) acquired from the full extent of the insula in 44 epileptic patients. Our study shows that both posterior and anterior subdivisions of the insular cortex respond to a nociceptive heat stimulus within a 200-400 ms latency range. This nociceptive cortical potential occurs firstly, and is larger, in the posterior granular insular cortex. The presence of phase reversals in LEP components in both posterior and anterior insular regions suggests activation of distinct, presumably functionally separate, sources in the posterior and anterior parts of the insula. Our results suggest that nociceptive input is first processed in the posterior insula, where it is known to be coded in terms of intensity and anatomical location, and then conveyed to the anterior insula, where the emotional reaction to pain is elaborated. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
    Human Brain Mapping 11/2014; 35(11). DOI:10.1002/hbm.22565 · 5.97 Impact Factor
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    ABSTRACT: Objective: The present study provides a functional mapping of vestibular responses in the human insular cortex. Methods: A total of 642 electrical stimulations of the insula were performed in 219 patients, using stereotactically implanted depth electrodes, during the presurgical evaluation of drug-refractory partial epilepsy. We retrospectively identified 41 contacts where stimulation elicited vestibular sensations (VSs) and analyzed their location with respect to (1) their stereotactic coordinates (for all contacts), (2) the anatomy of insula gyri (for 20 vestibular sites), and (3) the probabilistic cytoarchitectonic maps of the insula (for 9 vestibular sites). Results: VSs occurred in 7.6% of the 541 evoked sensations after electrical stimulations of the insula. VSs were mostly obtained after stimulation of the posterior insula, that is, in the granular insular cortex and the postcentral insular gyrus. The data also suggest a spatial segregation of the responses in the insula, with the rotatory and translational VSs being evoked at more posterior stimulation sites than other less definable VSs. No left-right differences were observed. Interpretation: These results demonstrate vestibular sensory processing in the insula that is centered on its posterior part. The present data add to the understanding of the multiple sensory functions of the insular cortex and of the cortical processing of vestibular signals. The data also indicate that lesion or dysfunction in the posterior insula should be considered during the evaluation of vestibular epileptic seizures.
    Annals of Neurology 10/2014; 76(4). DOI:10.1002/ana.24252 · 9.98 Impact Factor
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    ABSTRACT: Transcranial electric stimulation elicited muscle motor evoked potentials (TESmMEPs) is one of the best methods for corticospinal tract's function monitoring during spine and spinal cord surgeries. A train of multipulse electric stimulation is required for eliciting TESmMEPs under general anaesthesia. Here, we investigated the best stimulation parameters for eliciting and recording tibialis anterior's TESmMEPs during paediatric scoliosis surgery. Numbers of pulses (NOP), inter-stimulus intervals (ISI) and current intensities allowing the best size tibialis anterior muscle's TESmMEPs under general anaesthesia, were tested and collected during 77 paediatric scoliosis surgery monitoring procedures in our hospital. Individual pulse duration was kept at 0.5ms and stimulating electrodes were positioned at C1 and C2 (International 10-20-EEG-System) during all the tests. The NOP used for eliciting the best tibialis anterior TESmMEPs response was 5, 6, and 7 respectively in 21 (27%), 47 (61%) and 9 (12%) out of the 77 patients. The ISI was 2, 3 and 4 ms respectively in 13 (17%), 55 (71%) and 9 (12%) of them. The current intensity used varied from 300 to 700V (mean: 448±136 V). Most patients had 6 as best NOP (61%) and 3ms as best ISI (71%). These findings support that a NOP of 6 and an ISI of 3 ms should be preferentially used as optimal stimulation settings for intraoperative tibialis anterior muscle's TESmMEPs eliciting and recording during paediatric scoliosis surgery.
    Neurophysiologie Clinique/Clinical Neurophysiology 10/2013; 43(4):243-250. DOI:10.1016/j.neucli.2013.08.001 · 1.24 Impact Factor
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    Maud Frot · Michel Magnin · François Mauguière · Luis Garcia-Larrea ·
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    ABSTRACT: Intracortical evoked potentials to nonnoxious Aβ (electrical) and noxious Aδ (laser) stimuli within the human primary somatosensory (S1) and motor (M1) areas were recorded from 71 electrode sites in 9 epileptic patients. All cortical sites responding to specific noxious inputs also responded to nonnoxious stimuli, while the reverse was not always true. Evoked responses in S1 area 3b were systematic for nonnoxious inputs, but seen in only half of cases after nociceptive stimulation. Nociceptive responses were systematically recorded when electrode tracks reached the crown of the postcentral gyrus, consistent with an origin in somatosensory areas 1-2. Sites in the precentral cortex also exhibited noxious and nonnoxious responses with phase reversals indicating a local origin in area 4 (M1). We conclude that a representation of thermal nociceptive information does exist in human S1, although to a much lesser extent than the nonnociceptive one. Notably, area 3b, which responds massively to nonnoxious Aβ activation was less involved in the processing of noxious heat. S1 and M1 responses to noxious heat occurred at latencies comparable to those observed in the supra-sylvian opercular region of the same patients, suggesting a parallel, rather than hierarchical, processing of noxious inputs in S1, M1 and opercular cortex. This study provides the first direct evidence for a spinothalamic related input to the motor cortex in humans. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
    Human Brain Mapping 10/2013; 34(10). DOI:10.1002/hbm.22097 · 5.97 Impact Factor
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    Hélène Catenoix · François Mauguière · Marc Guénot · Jean Isnard · Philippe Ryvlin ·

    International journal of cardiology 09/2013; 169(2). DOI:10.1016/j.ijcard.2013.08.100 · 4.04 Impact Factor

Publication Stats

12k Citations
1,174.33 Total Impact Points


  • 2012-2015
    • French National Centre for Scientific Research
      Lutetia Parisorum, Île-de-France, France
  • 2007-2015
    • Hospices Civils de Lyon
      Lyons, Rhône-Alpes, France
  • 1995-2015
    • Claude Bernard University Lyon 1
      Villeurbanne, Rhône-Alpes, France
  • 2010-2013
    • Lyon Neuroscience Research Center
      Lyons, Rhône-Alpes, France
    • Université Jean Monnet
      Saint-Étienne, Rhône-Alpes, France
    • French Institute of Health and Medical Research
      Lutetia Parisorum, Île-de-France, France
  • 1990-2012
    • University of Lyon
      Lyons, Rhône-Alpes, France
    • Centre Hospitalier Universitaire de Saint-Étienne
      • Department of Neurology
      Saint-Étienne, Rhône-Alpes, France
  • 1989-2011
    • CHU de Lyon - Hôpital Neurologique et Neurochirurgical Pierre Wertheimer
      Lyons, Rhône-Alpes, France
  • 2008
    • HCL
      Noida, Uttar Pradesh, India
  • 2006
    • Centre Hospitalier Le Vinatier
      Брон, Rhône-Alpes, France
  • 2005
    • University of Malaga
      • Area of Physiology
      Málaga, Andalusia, Spain
    • The Neurosciences Institute
      لا هویا, California, United States
  • 1992-2000
    • CERMEP
      Rhône-Alpes, France
    • Unité Inserm U1077
      Caen, Lower Normandy, France
  • 1999
    • The Catholic University of America
      Washington, Washington, D.C., United States
  • 1996
    • Faculté des Sciences Ain Chock - Casablanca
      Anfa, Grand Casablanca, Morocco
  • 1994
    • Catholic University of the Sacred Heart
      • Institute of Neurology
      Roma, Latium, Italy
  • 1983
    • University Hospital Brussels
      Bruxelles, Brussels Capital, Belgium