S Brzeźnicki

Publications (3)2.5 Total impact

• Article: Elimination of 1-hydroxypyrene after human volunteer exposure to polycyclic aromatic hydrocarbons.

  S Brzeźnicki, M Jakubowski, B Czerski
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  ABSTRACT: The aim of this study was to estimate the kinetics of 1-hydroxypyrene (1-HP) elimination after inhalation exposure to polycyclic aromatic hydrocarbons (PAHs). Samples of inhaled and exhaled air were collected on glass fiber filters backed with tubes filled with Amberlit XAD-2 resin. The filters were extracted by cyclohexane and Amberlit--by acetonitrile. Extracts for the determination of pyrene and benzo[a]pyrene (B[a]P) concentrations were analyzed by high-performance liquid chromatography (HPLC). 1-Hydroxypyrene in urine was determined after its preconcentration on a C-18 column (solid phase extraction method) using the same analytical technique. Five male volunteers were exposed for 6 h (two times, with a 1-month interval) to a PAH mixture at an aluminium plant. The volunteers were breathing at rest through facial mask equipped with a 1000-ml compensation container which allows collection of the exhaled air. Inhaled air samples were collected in the breathing zone of each volunteer. Urine samples were collected until the 71st hour after the onset of exposure. The average respiratory retention of pyrene was found to be 61%. The 1-HP elimination process could be described by one-compartment model with the half-live of 9.8 hour (95% CI 7.9-11.7 h). The simulation of 1-HP elimination in urine during a working week (4 days) indicates that the balance between absorption and elimination is achieved at the end of the second day.
  Archiv für Gewerbepathologie und Gewerbehygiene 02/1997; 70(4):257-60. · 1.89 Impact Factor
• Article: [Determination of polycyclic aromatic hydrocarbons in the working environment during aluminum production].

  S Brzeźnicki, H Przybylski
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  ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) belong to a group od chemicals responsible, to a great extent, for the contamination of the industrial and ambient air. A number of industrial processes such as coke production, coal tar processing, production of electric energy and certain rubber goods as well as metallurgy, especially aluminium metallurgy with its anodes made of coal tar pitch are the major sources of PAH emission. An attempt was made to determine PAH concentrations at selected workposts at an aluminium production plant. Breathing zone air samples were collected by individual dosimetry. Coal tar pitch volatiles were determined by a gravimetric method and individual PAHs by HPLC. The presence of naphtalene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, triphenylene, benzo/a/anthracene, chrysene, benzo/a/pyrene, benzo/b/fluorenthene, benzo/k/fluoranthene, benzo/a/pyrene, dibenzo/a,h/anthracene, benzo/g,h,i/perylene and indeno/1,2,3-c,d/pyrene was identified at all investigated workposts. The highest concentrations of benzo/a/pyrene and coal tar pitch volatiles were found at workposts of crane operators which is due to the character of the work performed. The replacement of "wet" anode material by the "dry" one should contribute to improving of the working conditions.
  Medycyna pracy 02/1996; 47(1):1-8. · 0.30 Impact Factor
• Article: [Evaluation of the usefulness of 2-hydroxypyrene determination in urine and other possible tests for determining exposure to polycyclic aromatic hydrocarbons].

  S Brzeźnicki, M Jakubowski
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  ABSTRACT: Exposure to airborne polycyclic aromatic hydrocarbons (PAHs) occurring at production of coce and aluminium is one of the major occupational health problems. In workers exposed to airborne PAHs at high concentrations an increased incidence of lung cancer has been found. In the last decade numerous attempts were made to develop methods for the biological monitoring of exposure to this group od compounds. However, some of the methods like determination of thioethers in urine or urinary mutagenicity proved to be influenced to a large extent by cigarette smoking. Determination of 1-hydroxypyrene (1-HP) (pyrene metabolite) in urine seems to be a more promising approach. In a number of investigations relatively good correlation has been found between the concentration of pyrene and PAHs in the air as well as between the level of occupational exposure to pyrene and urinary excretion of 1-HP. The influence of cigarette smoking on the excretion of 1-HP in urine seems to be negligible as compared to the increase in 1-HP excretion in urine resulting from occupational exposure. Further investigations on the kinetics of excretion of 1-HP in urine and the quantitative relationship between the concentration of PAHs in the air and excretion of 1-HP in urine under relatively well controlled conditions are necessary.
  Medycyna pracy 02/1993; 44(4):355-62. · 0.30 Impact Factor