[show abstract][hide abstract] ABSTRACT: Disruption of intracoronary plaque with thrombus formation provides the pathophysiologic foundation for acute coronary syndromes, which comprise ST-segment myocardial infarction, non-ST-segment myocardial infarction, and unstable angina. Management differs depending on whether ST-segment elevation is present, but the general principles of timely restoration of coronary blood flow and initiation of secondary prevention strategies are applicable to all patients. The purpose of this review is to discuss first the epidemiology, pathophysiology, and diagnosis of acute myocardial infarction. Risk stratification and therapy for patients with ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndromes are then reviewed along with diagnosis and management of the complications of myocardial infarction.
Current problems in cardiology 07/2012; 37(7):237-310. · 3.96 Impact Factor
[show abstract][hide abstract] ABSTRACT: Libman-Sacks endocarditis is a well-described clinical entity in patients with systemic lupus erythematosus. Transesophageal echocardiography is the definitive imaging modality used in assessing cardiac valvular involvement in this disease process. Herein we describe a young Hispanic woman with systemic lupus erythematosus and multiple tricuspid valvular vegetations who developed splenic and cerebral infarctions while on optimal anticoagulation therapy with warfarin in the setting of a newly diagnosed patent foramen ovale. A review of the literature on Libman-Sacks endocarditis and patent foramen ovale closure is presented.
Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography 12/2007; 20(11):1316.e5-7. · 2.98 Impact Factor
[show abstract][hide abstract] ABSTRACT: Acute myocardial infarction (AMI) is a subset of the acute coronary syndromes and can be classified as being either a ST-segment elevation myocardial infarction (STEMI) or a non-ST-elevation myocardial infarction (NSTEMI). A clear distinction between STEMI and NSTEMI is essential because of the differences in management. The purpose of this review was to first discuss the epidemiology, pathophysiology, and diagnosis of AMI. The risk stratification and therapy of patients with STEMI and NSTEMI will then be reviewed as well as the complications of AMI.
Current Problems in Cardiology 01/2007; 31(12):769-817. · 2.54 Impact Factor