[show abstract][hide abstract] ABSTRACT: To assess the effect of road traffic exhaust on the risk of childhood leukemia, we carried out a population-based case-control study in the Province of Varese, northern Italy, covered by a population-based cancer registry. All 120 incident cases from 1978-97 were included in the study. Four controls per case, matched by age and gender, were sampled from population files. As index of exposure to traffic exhaust we estimated the annual mean concentration of benzene outside the home using a Gaussian diffusion model. This model uses traffic density (vehicles/day) on nearby main roads, distance between roads and residence, and information on vehicle emissions and weather conditions to estimate benzene concentration. Compared to children whose homes was not exposed to road traffic emissions (<0.1 microg/m(3) of benzene as estimated by the model), the risk of childhood leukemia was significantly higher (relative risk [RR] = 3.91; 95% confidence interval [CI] = 1.36-11.27) for heavily exposed children (over 10 microg/m(3) estimated annual average). For the intermediate exposure group (0.1-10 microg/m(3)) the relative risk was 1.51 (95% CI = 0.91-2.51). These data, considered with other available evidence, suggest that motor traffic emissions can be involved in the etiology of childhood leukemia.
International Journal of Cancer 02/2004; 108(4):596-9. · 6.20 Impact Factor
[show abstract][hide abstract] ABSTRACT: To evaluate the role of exposure to low-frequency electromagnetic fields generated by overhead power lines on the risk of childhood leukemia, we carried out a case-control study in the area (Varese province) covered by the Lombardy Cancer Registry.
Exposure to magnetic fields was estimated using line load data and the distance between subjects' homes and the nearest power line. A total of 101 cases and 412 controls were investigated.
Twenty subjects (9 cases and 11 controls) were considered exposed. A significant fourfold increase in risk for leukemia in exposed subjects and a dose-response relationship were found. The risk was higher than that reported by other studies. Potential biases related to the representativity of controls and validity of exposure assessment do not seem to have influenced the risk estimates.
We suggest that measures to remedy residential exposure should be taken wherever practicable.
[show abstract][hide abstract] ABSTRACT: Air pollution is associated with short- and long-term effects on "natural" mortality. Both can be viewed as the worsening of population health, more pronounced for long-term effects. A method for estimating this burden is proposed.
Epidemiologia e prevenzione 27(4):242-3. · 0.92 Impact Factor