E Nardini

Publications (3)17.83 Total impact

• Source

  Available from: nih.gov

  Article: Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice.

  A Balsari, C Rumio, D Morelli, L Sfondrini, E Nardini, I Barajon, S Ménard
  [show abstract] [hide abstract]
  ABSTRACT: One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.
  British Journal of Cancer 01/2002; 85(12):1964-7. · 5.04 Impact Factor
• Article: Identification of the human switch alpha 2 region from a low-grade malt lymphoma.

  E Nardini, S Rizzi, S Menard, A Balsari
  Mammalian Genome 01/2001; 11(12):1145-6. · 2.89 Impact Factor
• Article: Detection of aberrant isotype switch recombination in low-grade and high-grade gastric MALT lymphomas.

  E Nardini, A Aiello, R Giardini, M I Colnaghi, S Ménard, A Balsari
  [show abstract] [hide abstract]
  ABSTRACT: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma originates from reactive lymphocytic infiltrates during chronic gastritis, closely associated with Helicobacter pylori infection. MALT lymphomas may be either "low grade" or "high grade," and transformation from low grade to high grade can occur. To obtain information on the maturational state of MALT lymphoma cells, we investigated their ability to undergo isotype switch recombination, which together with immunoglobulin variable gene somatic mutation, contributes to normal B-cell maturation. Using specific probes for the immunoglobulin heavy-chain (IgH) switch regions, we found by Southern blot that 3 out of 5 low-grade cases and 2 out of 2 high-grade cases showed rearrangements within IgH switch regions, which appeared aberrant in 4 of the 5 cases. The cloning of two rearranged fragments from one low-grade and one high-grade case confirmed the aberrant nature of the rearranged fragments. A deletion from the switch mu region (S mu) to the first constant mu exon (C mu 1) and a second deletion from the second constant mu exon (C mu 2) to the gamma 3 region (gamma 3) was detected in the low-grade case. In the high-grade case, there was a deletion of the IgH intronic enhancer (E mu) and a 336-base pair (bp) insertion into the S mu region of a gene (KIAA0307) normally located at 15q24. These data demonstrate for the first time the ability of MALT lymphoma cells to undergo aberrant isotype switch recombinations, which might be directly involved in the development or progression of malignancy.
  Blood 03/2000; 95(3):1032-8. · 9.90 Impact Factor