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E Antón,
A Casanova,
A Xaubet,
A Román,
V Villena,
M C Montero,
M Molina-Molina,
E Pérez-Sánchez,
A Sueiro,
F Morell,
R M Girón,
J Ancochea
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ABSTRACT: Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease that almost exclusively affects young women of childbearing age. The true incidence and prevalence of LAM are unknown. This study was conducted to evaluate the characteristics of lymphangioleiomyomatosis in Spain.
Over a 2-year period, a questionnaire designed for this study was collected. This questionnaire included sociodemograhic, clinical, radiological and functional data. Information about the study and this questionnaire were both sent by e-mail to all the participants of the interstitial disease registry of 2004.
Seventy-two patients, all of whom were women, were included in the registry, with a mean age of 44.56 +/- 11.1 yr. Sixty-three patients (87.5%) presented the sporadic LAM and 9 (12.5%) presented LAM associated with tuberous sclerosis (LAM-TS). LAM diagnosis was confirmed with an open lung biopsy in 57 patients (79.2%) and was performed with thoracic HRCT compatible with LAM diagnosis in the other 15 cases. The most frequent symptom was dyspnoea (90%) followed by cough (44.4%). Almost 40% of patients presented renal angiomyolipomas in the study and the most frequent spirometric pattern was obstructive in more than half of the patients. Most patients with LAM-TS (88.8%) had renal angiomyolipomas compared with 31.7% in the sporadic LAM group.
The characteristics of the Spanish population affected with LAM are similar to those of other countries. Most patients were symptomatic, had a history of previous pneumothorax and presented abnormal radiological findings and pulmonary function tests.
Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 07/2009; 26(2):85-91. · 1.27 Impact Factor
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ABSTRACT: Patients with cystic fibrosis are at great risk of infection by nontuberculous mycobacteria from the environment because of certain predisposing factors such as bronchiectasis, malnutrition, and diabetes. The aim of this study was to analyze the mycobacterial content of sputum smears and cultures from adult patients with cystic fibrosis attended at a specialized unit for adults from March 1997 through December 2001.
Sputum samples were collected prospectively according to a protocol applied at each visit, and during most exacerbations staining and culture for mycobacteria were ordered in addition to the usual cultures for bacteria and fungi. A tuberculin test was performed at the end of the study.
Twenty-eight patients (16 men) with cystic fibrosis were enrolled. The mean (SD) age was 25.3 (6.7) years. A total of 251 samples were cultured (range in number of samples per patient, 1-31). The mean period of follow up was 40.3 (22.1) months. The sputum smear was positive in 29 cases (4 patients); the culture was positive in 7 patients. More than 3 samples were positive in only 4 patients. Mycobacterium abscessus was isolated in 3 cases, Mycobacterium avium complex in 2 and Mycobacterium simiae in 1 and other an unidentified rapid growth Mycobacterium species. The Mantoux test was positive in 5 patients. Two of the 4 patients in whose samples mycobacteria were isolated repeatedly required treatment.
The prevalence of nontuberculous mycobacterial infection is high in patients with cystic fibrosis. Staining and culture for mycobacteria should be carried out regularly and whenever exacerbation of pulmonary symptoms cannot be attributed to bacteria usually found in such patients. Patients with recurrent isolations of mycobacteria should be monitored closely.
Archivos de Bronconeumología 11/2005; 41(10):560-5. · 2.17 Impact Factor
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Archivos de Bronconeumología 01/2005; 40 Suppl 6:16-22. · 2.17 Impact Factor
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ABSTRACT: ObjectivePatients with cystic fibrosis are at great risk of infection by nontuberculous mycobacteria from the environment because of certain predisposing factors such as bronchiectasis, malnutrition, and diabetes. The aim of this study was to analyze the mycobacterial content of sputum smears and cultures from adult patients with cystic fibrosis attended at a specialized unit for adults from March 1997 through December 2001.Patients and methodsSputum samples were collected prospectively according to a protocol applied at each visit, and during most exacerbations staining and culture for mycobacteria were ordered in addition to the usual cultures for bacteria and fungi. A tuberculin test was performed at the end of the study.ResultsTwenty-eight patients (16 men) with cystic fibrosis were enrolled. The mean (SD) age was 25.3 (6.7) years. A total of 251 samples were cultured (range in number of samples per patient, 1-31). The mean period of follow up was 40.3 (22.1) months. The sputum smear was positive in 29 cases (4 patients); the culture was positive in 7 patients. More than 3 samples were positive in only 4 patients. Mycobacterium abscessus was isolated in 3 cases, Mycobacterium avium complex in 2 and Mycobacterium simiae in 1 and other an unidentified rapid growth Mycobacterium species. The Mantoux test was positive in 5 patients. Two of the 4 patients in whose samples mycobacteria were isolated repeatedly required treatment.ConclusionsThe prevalence of nontuberculous mycobacterial infection is high in patients with cystic fibrosis. Staining and culture for mycobacteria should be carried out regularly and whenever exacerbation of pulmonary symptoms cannot be attributed to bacteria usually found in such patients. Patients with recurrent isolations of mycobacteria should be monitored closely.ObjetivoLOS pacientes con fibrosis quística (FQ) presentan un mayor riesgo de infección por micobacterias ambientales en relación con ciertos factores predisponentes como bronquiectasias, desnutrición y diabetes. El objetivo del presente estudio es analizar los resultados de las baciloscopias y cultivos de micobacterias de esputos de pacientes con FQ de una unidad de adultos, entre marzo de 1997 y diciembre de 2001.Pacientes y métodosLas muestras de esputo se recogieron de forma prospectiva y protocolizada en cada visita y en la mayoría de las exacerbaciones, en las que, además de los cultivos bacterianos habituales y de hongos, se solicitaron tinción y cultivo para micobacterias. Se realizó la prueba de la tuberculina al final del estudio.ResultadosSe incluyó a 28 pacientes con FQ, 16 varones, con una edad media (± DE) de 25,3 ± 6,7 años. Se cultivaron un total de 251 muestras (rango por paciente de 1 a 31). El tiempo medio de seguimiento fue de 40,3 ± 22,1 meses. En 29 casos (4 pacientes) la baciloscopia fue positiva y se obtuvieron cultivos positivos en 7 pacientes, sólo en 4 en más de 3 muestras. Se aislaron: Mycobacterium abscessus en 3 casos, M. avium complex en 2 y M. simiae en uno y en otro una especie de crecimiento rápido no identificada. En 5 pacientes el Mantoux fue positivo. Dos de los 4 pacientes con aislamientos reiterados presentaron deterioro clínico y requirieron tratamiento.ConclusionesHay una alta prevalencia de micobacterias ambientales en pacientes con FQ. Habría que realizar tinción y cultivo para micobacterias de forma periódica y en caso de exacerbación pulmonar no atribuible a infección bacteriana habitual. Hay que vigilar estrechamente a los pacientes con aislamientos repetidos.
Archivos de Bronconeumología ((English Edition)).
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ABSTRACT: Objetivo: Los pacientes con fibrosis quística (FQ) presentan un mayor riesgo de infección por micobacterias ambientales en relación con ciertos factores predisponentes como bronquiectasias, desnutrición y diabetes. El objetivo del presente estudio es analizar los resultados de las baciloscopias y cultivos de micobacterias de esputos de pacientes con FQ de una unidad de adultos, entre marzo de 1997 y diciembre de 2001. Pacientes y métodos: Las muestras de esputo se recogieron de forma prospectiva y protocolizada en cada visita y en la mayoría de las exacerbaciones, en las que, además de los cultivos bacterianos habituales y de hongos, se solicitaron tinción y cultivo para micobacterias. Se realizó la prueba de la tuberculina al final del estudio. Resultados: Se incluyó a 28 pacientes con FQ, 16 varones, con una edad media (± DE) de 25,3 ± 6,7 años. Se cultivaron un total de 251 muestras (rango por paciente de 1 a 31). El tiempo medio de seguimiento fue de 40,3 ± 22,1 meses. En 29 casos (4 pacientes) la baciloscopia fue positiva y se obtuvieron cultivos positivos en 7 pacientes, sólo en 4 en más de 3 muestras. Se aislaron: Mycobacterium abscessus en 3 casos, M. avium complex en 2 y M. simiae en uno y en otro una especie de crecimiento rápido no identificada. En 5 pacientes el Mantoux fue positivo. Dos de los 4 pacientes con aislamientos reiterados presentaron deterioro clínico y requirieron tratamiento. Conclusiones: Hay una alta prevalencia de micobacterias ambientales en pacientes con FQ. Habría que realizar tinción y cultivo para micobacterias de forma periódica y en caso de exacerbación pulmonar no atribuible a infección bacteriana habitual. Hay que vigilar estrechamente a los pacientes con aislamientos repetidos.
Archivos de bronconeumología: Organo oficial de la Sociedad Española de Neumología y Cirugía Torácica SEPAR y la Asociación Latinoamericana de Tórax (ALAT), ISSN 0300-2896, Vol. 41, Nº. 10, 2005, pags. 560-565.
