E Bonifazi

Università degli Studi di Bari Aldo Moro, Bari, Apulia, Italy

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Publications (56)63.07 Total impact

  • Mario Cutrone · Ernesto Bonifazi
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    ABSTRACT: Noninvoluting congenital hemangiomas (NICHs) are vascular tumors that are fully formed at birth and do not regress. Clinically, NICHs persist indefinitely over time. Histologically they are characterized by deep dermal lobules of small vessels with endothelial cells that do not stain with glucose transporter 1 (GLUT1). Two similar cases of unusually large, patch-type NICHs of the shoulder in neonates were observed in the past 20 years in two pediatric dermatology units in Italy. In both cases, histopathology showed lobular collections of small vessels that did not stain with GLUT1. The clinical features of the two cases remained unchanged over a follow-up period of 10 and 4 years, respectively. The large size and flat appearance of the lesions could be due to their early onset during embryogenesis.
    Pediatric Dermatology 01/2015; 32(5). DOI:10.1111/pde.12510 · 1.02 Impact Factor
  • E. Bonifazi · A. Milano
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    ABSTRACT: The histiocytoses are diseases caused by the proliferation of histiocytes in various organs, including the skin; they have a very variable clinical spectrum and prognosis ranging from an often fatal multisystem involvement to a self-healing single lesion in a single organ. The classification of histiocytosis, which is based on the origin cell and malignancy potential, divides them into Langerhans cell histiocytosis (Class I), non-Langerhans histiocytosis (Class II) and malignant histiocytosis (Class III). In each of these classes numerous clinical forms have been described, but these forms according to some Authors only represent different developmental stages of the same disease. Letterer-Siwe disease is the most frequent form among Class I histiocytoses and juvenile xanthogranuloma and Rosai-Dorfman disease are the most frequent forms among Class II Histiocytoses. In Class I histiocytoses the histologic examination is not able to distinguish between severe and mild forms; the observation of the skin lesions can help in this differentiation.
    European Journal of Pediatric Dermatology 01/2015; 25(1):27-52.
  • Ernesto Bonifazi · Antonella Milano · Caterina Foti
    Contact Dermatitis 10/2014; 71(4). DOI:10.1111/cod.12248 · 3.75 Impact Factor
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    Mario Cutrone · ernesto bonifazi
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    ABSTRACT: The term cutis marmorata is used to indicate both a physiological reaction to the cold occurring in many babies and sometimes even in older children and a persistent capillary-venous malformation. The latter is mostly visible at birth, when necrotic and ulcerative lesions can be associated, and then improves in decades. The different prognosis calls for a differential diagnosis between the two conditions.
  • Cutrone M · Milano A · Rovatti G · Bonifazi E
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    ABSTRACT: We revisit the anatomical variants of the male genitalia (pigmentary changes, variants of the median raphe, pearly penile papules, sebaceous hyperplasia, non-retractable foreskin, smegma pseudocysts), female genitalia (hypertrophy of the labia, vaginal discharge, hymen tags, fusion of the labia minora, furrows and maceration of the lips, vestibular papillomatosis) and anus (infantile perianal protrusion). These anatomical variants can simulate pathological conditions which must be differentiated. The anatomical variants in most cases do not require any therapy.
    European Journal of Pediatric Dermatology 05/2013; 23, 29-45, 2013(1).
  • V. Salerno · A. Mangione · L. Garofalo · E. Bonifazi
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    ABSTRACT: Oro-facial and ano-genital granulomatosis represent two aspects of the same chronic inflammatory disorder probably related with Crohn's disease. In this paper we describe three pediatric cases of granulomatosis, one oro-facial and two ano-genital; the second of these two cases was followed after years of observation by full-blown Crohn's disease. On the basis of personal data and review of the literature we emphasize the importance of lymphangiectasias, often visible not only histologically but also clinically, for proper diagnosis of the disease.
    European Journal of Pediatric Dermatology 10/2012; 22(4):263-268.
  • Ernesto Bonifazi
    Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition, 05/2011: pages 19.1 - 19.4; , ISBN: 9781444345384
  • Ernesto Bonifazi
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    ABSTRACT: Pityriasis lichenoides (PL) is an uncommon disease clinically characterized by recurrent crops of usually asymptomatic haemorrhagic papules lasting from several months to years. The presence of a CD4+ T-cell clone in the inflammatory dermal infiltrate of PL may be expression of the host response to a viral causal factor. The laboratory investigations are usually within normal limits in PL. The clinical course of PL is characterized by spontaneous resolution in most cases, except for some case of febrile ulceronecrotic variant and exceptional cases of PL that subsequently developed lymphoma in the adulthood. Treatment is not necessary in most cases.
    Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition, 05/2011: pages 100.1 - 100.3; , ISBN: 9781444345384
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    ABSTRACT: The natural evolution of melanocytic nevi is a complex, multifactorial process that can be studied by monitoring nevi on a long-term basis. To assess the evolution pathway of Spitz nevi, lesions with clinical and dermoscopic features suggestive of Spitz nevi were monitored and baseline and follow-up images compared. Sixty-four patients (mean age 10.4 years) with lesions suggestive of Spitz nevi were included. Lesions were monitored for a mean follow-up period of 25 months. Upon side-by-side evaluation of baseline and follow-up images, 51 (79.7%) lesions showed an involution pattern and 13 (20.3%) lesions showed a growing or stable pattern. No significant differences were found between growing and involving lesions in terms of patient age and sex and the location and palpability of lesions. The great majority of growing lesions were pigmented or partially pigmented (92.3%), whereas 47.1% of lesions in involution were amelanotic (p = 0.005). In this series of lesions clinically and dermoscopically diagnosed as Spitz nevi, spontaneous involution seems to be the most common biologic behavior.
    Dermatology 04/2011; 222(3):256-60. DOI:10.1159/000326109 · 1.57 Impact Factor
  • Mario Cutrone · irene berti · ernesto bonifazi
    Medico e Bambino 04/2011;
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    ABSTRACT: The aim of our study was to provide a psychosocial and psychiatric evaluation of patients with epidermolysis bullosa (EB; a rare genetic disorder characterized by skin fragility), to assess psychological status, ascertain the presence of any psychiatric disorders and understand the impact of EB on quality of life. Twenty-five patients were assessed using a case record form and several standardized instruments. In 82% of patients, EB had a negative impact on quality of life and 80% of patients experienced psychiatric symptoms. Our findings revealed a high prevalence of psychosocial problems and psychiatric symptoms in patients with EB and suggested that a combined bio-psychosocial approach is the most appropriate therapeutic intervention.
    Journal of Clinical Psychology in Medical Settings 12/2010; 17(4):333-9. DOI:10.1007/s10880-010-9205-4 · 1.49 Impact Factor
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    ABSTRACT: A 27-day-old male infant with diffuse hemangiomatosis of the skin and liver was treated with oral propranolol at a dosage of 2 mg/kg per day. Five months later skin and liver hemangiomas regressed almost completely. After 160 days of onset of propranolol, the patient presented with seizures on waking up. Laboratory examinations showed blood glucose of 15 mmol (n.v. 50-110) and increased ketone bodies. Propranolol was recommenced at a lower dosage the day after the crisis and then withdrawn when the baby was aged ten months. Hypoglycemia is the most frequent and insidious side effect of propranolol, mainly occurring in circumstances with diminished oral intake. Although the risk appears small, increased vigilance for hypoglycemia in children on chronic propranolol treatment who have decreased caloric intake for any reason seems prudent.
    Pediatric Dermatology 02/2010; 27(2):195-6. DOI:10.1111/j.1525-1470.2009.01081.x · 1.02 Impact Factor
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    ABSTRACT: This contribution describes a recent experimental study of the reaction on light nuclei, , , and . Final π±Σ∓ pairs arise from π+π−n events. For some nuclei, the π+ momentum spectrum presents peak-strucures in the kinematical interval of formation of Σ-hypernuclear states. The apparatus used for the investigation is the FINUDA spectrometer set at DAΦNE.
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    ABSTRACT: Novel data from the Kstop^ - A absorption reaction in light nuclei are presented. The data were collected by the FINUDA spectrometer running at the DAPhiNE varphi-facility, Laboratori Nazionali di Frascati (LNF), Italy.
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    Antonella Milano · Mario Cutrone · Nicola Laforgia · Ernesto Bonifazi
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    ABSTRACT: Between March and October 2008, the nails of 541 (252 females, 289 males) consecutively born neonates with an average age of 3.2 days were examined in the Neonatology Unit. Of these newborns with nail disorders, 36 were re-examined after a period that ranged from seven days to six months. The most frequent nail alteration was the incomplete development of the hallux nail, which was triangular - sometimes trapezoidal - shaped. This alteration, which had been previously reported in the literature as congenital hypertrophy of the lateral folds of the hallux, spontaneously regressed within one to three months in the infants re-examined. There was no associated inflammation or onychocryptosis at any time. The apparent hypertrophy of the nail folds seemed to be secondary to the lack of pressure of the nail lamina.
    Dermatology online journal 01/2010; 16(6):1.
  • V Colonna · L Resta · Napoli AE · E Bonifazi
    British Journal of Dermatology 10/2009; 162(1):208-9. DOI:10.1111/j.1365-2133.2009.09493.x · 4.28 Impact Factor
  • N. Laforgia · A. Milano · E. De Leo · E. Bonifazi
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    ABSTRACT: 23 cases of hemangioma treated with oral propranolol at a dosage of 2 mg/kg per day were reported. 11/23 cases stopped treatment and were monitored for an average period of three months after drug withdrawal. Propranolol was as effective as corticosteroids in blocking the growth of hemangioma and in causing a significant reduction both of the size and color of hemangioma. These effects, however, seem less permanent as compared with those ones caused by corticosteroids, requiring a longer duration of treatment -7 months on average-. Apart from heart contraindications, however rare, bronchospasm, which is frequent at this age, but more often inflammatory than muscular, is not an absolute contraindication to the usage of the drug. Hypoglicemia is the most dangerous side effect of propranolol.
    European Journal of Pediatric Dermatology 07/2009; 19(3):175-191.
  • Dermatology 05/2009; 219(1):3-6. DOI:10.1159/000213759 · 1.57 Impact Factor
  • Mario Cutrone · irene berti · ernesto bonifazi · pietro dalmonte
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    ABSTRACT: A 2-year-old girl was first observed due to angiomatous lesions of the left parietal region and neck, which were present since birth. Her mother told us a very precise history, documented by photos. The lesions were present since birth, their distribution and extent did not change with time and there was not a growing phase. On physical examination the little girl presented on her left frontal and parietal region and on the neck angiomatous lesions. The latter were confluent upon the ear. Three isolated, 3 cm in size lesions were located on the neck under the ear. Two smaller, isolated lesions were located on the left parietal region behind the largest confluent patch and finally a few mm in size angiomatous lesions were located on the rear surface of the left helix and preauricular region. The larger lesions were characterized by a peripheral barely raised border and by a whitish, atrophic center crossed by the hairs (Fig. 4). The photos given by her mother confirmed that distribution and extent of the lesions did not change with time and showed that the lesions at birth were uniformly red colored (Fig. 1, 2) and that after the first year turned into atrophic white lesions in the center (Fig. 3). With time atrophy got progressively more evident and extended towards the periphery, where a red, 6-8 mm in size border still persisted. The patient was observed by pediatricians, dermatologists, pediatric dermatologists and vascular surgeons, their diagnosis ranging between hemangioma and capillary malformation. Color Doppler ultrasonography performed in the IRCCS Giannina Gaslini Institute did not remove the doubt between hemangioma and capillary and venous malformation. Brain MRI did not show pathological findings. In the same department an isolated lesion of the neck was removed and the histological examination showed capillaries and venules in the dermis and subcutaneous fat tissue, leading to the final diagnosis of vascular malformation of venous capillary type. A careful observation of the histological sections showed in the middle of the lesion a thinned dermis with decreased number of vessels and an almost rectlineal dermal epidermal junction. These findings were consistent with the clinical atrophic appearance of the superficial skin.
    European Journal of Pediatric Dermatology 01/2009;

Publication Stats

295 Citations
63.07 Total Impact Points


  • 1975–2015
    • Università degli Studi di Bari Aldo Moro
      • • Dipartimento di Scienze Biomediche ed Oncologia Umana (DIMO)
      • • Department of Chemistry
      Bari, Apulia, Italy
  • 2010
    • Università degli Studi di Trieste
      • Department of Physics
      Trst, Friuli Venezia Giulia, Italy