D Y Kim

National Cancer Center Korea, Kōyō, Gyeonggi Province, South Korea

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Publications (60)100.43 Total impact

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    ABSTRACT: Objectives: Sublingual immunotherapy (SLIT) has recently received much attention around the world as a treatment of allergic rhinitis (AR). However, some patients experience early adverse events (EAE) during SLIT. This study aimed to investigate the predisposing conditions of EAE and the influence of EAE on treatment outcomes in the house dust mite (HDM) SLIT for AR.
    Otolaryngology Head and Neck Surgery 09/2014; 151(1 Suppl):P250-P250. DOI:10.1177/0194599814541629a355 · 1.72 Impact Factor
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    ABSTRACT: AimAlthough serum carcinoembryonic antigen (CEA) level is prognostic in colorectal cancer, the prognostic role of tumour CEA expression is unclear. The aim of this study is to identify the prognostic and surveillance roles of tissue CEA expression along with serum CEA concentration in patients curatively resected for colorectal cancer. Method Between January and December 2003, 294 patients who underwent curative resection for colorectal cancer were included in the study. Correlation of tissue CEA expression with overall survival (OS), disease-free survival (DFS) and elevated serum CEA concentration at tumour recurrence were analysed. ResultsTissue CEA expression was positive in 215 patients (73.1%). CEA expression was an independent prognostic factor for OS [hazard ratio (HR)=2.537, 95% confidence interval (CI)=1.065-6.042, P=0.035] and DFS (HR=3.090, 95% CI=1.405-6.795, P=0.005). Elevation of serum CEA at tumour recurrence was significantly lower in patients without than with tissue CEA expression (14.3 vs 57.6%, P=0.045). Moreover, when patients were grouped according to a combination of serum CEA elevation and tissue CEA expression, those with tissue CEA expression and elevated serum CEA (group 3) had significantly poorer OS and DFS (P<0.001 each) than those without CEA expression and elevated serum CEA (group 1) and those with either tissue CEA expression or elevated serum CEA (group 2). OS (P=0.006) and DFS (P=0.027) were both significantly greater in group 1 than in group 2. Conclusion Tissue CEA expression is a prognostic factor in patients with colorectal cancer. Analysis of tissue CEA expression may be helpful in determining the clinical utility of serial measurements of serum CEA as surveillance in patients with curatively resected colorectal cancer.
    Colorectal Disease 05/2013; 15(9). DOI:10.1111/codi.12304 · 2.02 Impact Factor
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    ABSTRACT: Background We conducted a population-based retrospective cohort study to investigate the influence of hospital volume, delay of surgery, and both together on the long-term survival of postoperative cancer patients. Methods Using information from the Korea Central Cancer Registry from 2001 through 2005 and the National Health Insurance claim database, we determined survival for 147 682 patients who underwent definitive surgery for any of six cancers. Results Regardless of cancer site, surgical patients in low- to medium-volume hospitals showed significantly worse survival [adjusted hazard ratio (aHR) = 1.36-1.86] than those in high-volume hospitals in multivariable analyses. Among the latter, treatment delays > 1 month were not associated with worse survival for stomach, colon, pancreatic, or lung cancer but were for rectal [aHR = 1.28; 95% confidence interval (CI), 1.17-1.40] and breast (aHR = 1.59; 95% CI, 1.37-1.84) cancer. For patients in low- to medium-volume hospitals, treatment delay was associated with worse survival for all types of cancer (aHR = 1.78-3.81). Conclusion Our findings suggest that the effect of hospital volume and surgical treatment delay on overall survival of cancer patients should be considered in formulating or revising national health policy.
    Annals of Oncology 05/2012; 23(10):2731-7. DOI:10.1093/annonc/mds101 · 6.58 Impact Factor
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    ABSTRACT: To evaluate the prognostic effect of lymph node ratio (LNR) in patients with locally advanced rectal cancer who were treated with curative resection after preoperative chemoradiotherapy (CRT). Between October 2001 and December 2007, 519 patients who had undergone curative resection of primary rectal cancer after preoperative CRT were enrolled. Of these, 154 patients were positive for lymph node (LN) metastasis and were divided into three groups according to the LNR (≤ 0.15 [n=80], 0.16-0.3 [n=44], >0.3 [n=30]) to evaluate the prognostic effect on overall survival (OS) and disease-free survival (DFS). LNR (≤ 0.15, 0.16-0.3, and >0.3) was significantly associated with 5-year OS (90.3%, 75.1%, and 45.1%; p<0.001) and DFS (66.7%, 55.8%, and 21.9%; p<0.001) rates. In a multivariate analysis, LNR (≤ 0.15, 0.16-0.3, and >0.3) was a significant independent prognostic factor for OS (hazard ratios [HRs], 1, 3.609, and 8.197; p<0.001) and DFS (HRs, 1, 1.699, and 3.960; p<0.001). LNR had a prognostic impact on OS and DFS in patients with <12 harvested LNs, as well as in those with ≥ 12 harvested LNs (p<0.05). LNR was a significant independent prognostic predictor for OS and DFS in patients with locally advanced rectal cancer who were treated with curative resection after preoperative CRT.
    European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 03/2012; 38(6):478-83. DOI:10.1016/j.ejso.2012.03.002 · 2.89 Impact Factor
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    ABSTRACT: Objective: The pedicled septal flap (SF) is one of the most valuable methods to reconstruct the surgical defect after endoscopic skull base surgery. We aimed to assess the feasibility of the SF for reconstruction of the entire anterior SBD in Koreans and attempted to provide tips for improving its design.
    Otolaryngology Head and Neck Surgery 09/2011; 145(2 Suppl):P265-P265. DOI:10.1177/0194599811415823a428 · 1.72 Impact Factor
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    Sucbei Moon, D.Y. Kim
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    ABSTRACT: We present a reflectometric measurement scheme of group-velocity dispersion for an optical fiber, whose measurement range covers the entire band of optical communication from 1200 to 1700 nm in wavelength by using a wideband supercontinuum source. In our measurement scheme, wavelength-dependent temporal delays are measured for spectrum-sliced supercontinuum pulses that have passed through a fiber under measurement (FUM). A reflectometric configuration is used to increase the accuracy of the measurement results by eliminating the effect of timing instabilities of the light source and the detection electronics. The time of flight is measured by taking the relative delay between two pulses back reflected by the two ends of an FUM. The delay measurement is performed for two wavelengths simultaneously to minimize the effect of the temperature-sensitive drift. We have successfully demonstrated that our scheme can characterize a relatively short single-mode fiber of 10 m with a good measurement accuracy.
    IEEE Photonics Technology Letters 10/2009; 21(17-21):1262 - 1264. DOI:10.1109/LPT.2009.2025381 · 2.18 Impact Factor
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    ABSTRACT: Chronic rhinosinusitis with nasal polyposis (CRSNP) and asthma are inflammatory lesions of the respiratory epithelium. This study was conducted to evaluate predictive factors of bronchial hyperresponsiveness (BHR) in patients with CRSNP. BHR was evaluated using a methacholine bronchoprovocation test (MBPT) in 122 consecutive patients newly diagnosed with CRSNP at Seoul National University Hospital from January 2004 to June 2006. The following parameters were analyzed and compared between the BHR and non-BHR groups: symptoms, atopic status, current smoking, disease severity of CRSNP based on the Lund-Mackay scoring system of sinus CT, and counts of eosinophils in the serum and nasal tissues. Thirty-five percent of the patients were found to have BHR, and BHR was found to occur more frequently in patients that were currently suffering from sneezing (P = 0.007). In addition, the mean eosinophil counts of the serum and nasal tissues were higher in the BHR group than in the non-BHR group (P = 0.001 for the serum, P = 0.045 for the nasal tissues), and the eosinophil counts of the serum correlated to those of the nasal tissues (r = 0.334, P = 0.013). The disease severity, as determined by the Lund-Mackay scoring system, was not different between the two groups (P > 0.05). The best cutoff serum eosinophil count for predicting BHR in CRSNP patients was determined to be 300 cells/microl (sensitivity 70%, specificity 70%). Taken together, these results indicate that moderate to severe sneezing and a serum eosinophil count > or = 300 cells/microl may be predictive factors for BHR in patients with CRSNP.
    Allergy 01/2009; 64(1):118-22. DOI:10.1111/j.1398-9995.2008.01841.x · 6.00 Impact Factor
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    ABSTRACT: To investigate clinicopathologic findings of patients with small cell carcinoma of the uterine cervix (SCCUC), and evaluate their prognosis. We retrospectively reviewed the medical records of 20 patients with histologically confirmed SCCUC treated between October 1996 and December 2004 at Asan Medical Center, Korea. The review included demographic data, pathologic findings, treatments, and outcomes. Of 1,358 invasive cervical carcinoma, the incidence of SCCUC was 1.5%. Median age was 45.5 years. The clinical stages were Ib in 11, IIa in two, IIb in one, IIIa in one, IIIb in one, IVa in three and IVb in one. Fourteen patients underwent radical hysterectomy. Ten patients are alive and nine show no evidence of disease. Median overall survival was 77.0 months and 5-year overall survival rate was 50%. There was significant difference in overall survival with FIGO stage and tumor mass size. Advanced FIGO stage and tumor mass size are poor prognostic factors for overall survival in patients with SCCUC. Even though SCCUC is a highly aggressive neoplasm, early diagnosis and combined therapeutic modalities may lead to longer survival in some patients.
    European journal of gynaecological oncology 01/2009; 30(5):539-42. · 0.60 Impact Factor
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    ABSTRACT: To evaluate the outcomes of pregnancy in young women (<40 years old) with early endometrial cancer or atypical complex hyperplasia who were treated by conservative management followed by assisted reproductive technology (ART). Medical charts of 11 patients treated from January 1997 to October 2007 at Asan Medical Center were retrospectively reviewed. These patients had all been treated with progestin and serial dilatation and curettage as primary fertility-preserving therapies. After pathological remission of disease, 10 patients tried to become pregnant by ART, 4 by in vitro fertilization and embryo transfer, and 6 by controlled ovarian hyperstimulation, with or without intrauterine insemination. Eight women had intrauterine pregnancies, and 6 patients had live births. Patients have been followed up for 9 to 51 months (mean, 21 months) after delivery, with no evidence of tumor recurrence. Fertility-preserving therapy followed by ART can be a good option in well-selected patients with early endometrial cancer who want to become pregnant.
    International Journal of Gynecological Cancer 01/2009; 19(1):147-51. DOI:10.1111/IGC.0b013e31819960ba · 1.95 Impact Factor
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    ABSTRACT: The objective of this study was to evaluate the validity and clinical impact of positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) using 18-fluoro-2-deoxy-D-glucose in the posttherapy surveillance of patients with endometrial carcinoma. Eighty-eight patients previously treated for histopathologically diagnosed endometrial adenocarcinoma underwent 99 PET or PET/CT scans at follow-up visits at Asan Medical Center, Seoul, Korea, between 2001 and 2007. The standard of reference for tumor recurrence consisted of histopathologic confirmation or follow-up information at least 6 months after PET or PET/CT. Of the 88 patients, 24 underwent PET (n = 11) and/or PET/CT (n = 14) scans due to suspected disease recurrence. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of PET and/or PET/CT in detecting recurrence in these patients were 100%, 83.3%, 96%, 95%, and 100%, respectively. Especially, PET/CT revealed true-positive findings in three patients with elevated tumor markers but negative CT findings. The remaining 64 patients underwent PET (n = 8) and/or PET/CT (n = 66) as part of routine posttherapy surveillance; these patients were asymptomatic, with no evidence of disease. The sensitivity, specificity, accuracy, PPV, and NPV of PET and/or PET/CT in detecting recurrence in these patients were all 100%. Clinical decisions on treatment were changed in 14 (21.9%) patients by introducing PET or PET/CT into their conventional posttherapy surveillance program. PET and/or PET/CT were highly effective in discriminating true recurrence in patients with suspected recurrence, highly sensitive in detecting recurrence in asymptomatic patients, and had impacts on clinical decisions in a considerable portion of patients.
    International Journal of Gynecological Cancer 10/2008; 18(6):1332 - 1338. DOI:10.1111/j.1525-1438.2008.01197.x · 1.95 Impact Factor
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    J Y Lee, T-J Ahn, D Y Kim
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    ABSTRACT: We present a low coherent hybrid detection technique for the differential model delay (DMD) measurement of a conventional optical multimode fiber with a modified Mach-Zehnder interferometer. A low coherent hybrid detection technique enhances mode coupling between guided modes and the reference mode to easily resolve the modal distribution. An optical spectrum analyzer and a broadband source were used to obtain time-resolved optical beat signals. The measured interference signal was Fourier transformed to obtain time-delay information. A scanning offset launching method was used to excite every available mode in a multimode fiber (MMF). Measurements of a conventional 8-m-long MMF demonstrated the validity of our proposed method. The experimental results of our proposed method agree well with results obtained using a conventional time domain measurement method. Our proposed method can be used to measure the DMD in a short length of optical MMF with a temporal resolution better than 0.72 ps when using an 8-m-long single-mode fiber as a reference.
    Applied Optics 03/2008; 47(6):725-30. DOI:10.1364/AO.47.000725 · 1.69 Impact Factor
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    ABSTRACT: We propose an angular offset technique for launching optical signals into multimode fibers (MMFs) used in short distance optical fiber links. The signal is launched onto the angled facet of an MMF. The presented method shows better bandwidth enhancement in comparison with the conventional lateral offset launching method with a little power penalty. This method is simple and can be easily adopted in transmitters for high-speed MMF links. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 165–168, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22988
    Microwave and Optical Technology Letters 01/2008; 50(1):165 - 168. DOI:10.1002/mop.22988 · 0.62 Impact Factor
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    J Y Lee, D Y Kim
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    ABSTRACT: We present a novel spectrum-slicing method for measuring the chromatic dispersion of an optical fiber in Fourier-domain low-coherence interferometry. Broadband spectral interference data obtained from a low-coherence interferometer is sliced with Gaussian window functions. Each sliced spectral datum is used to calculate a relative group delay with Fourier transformation at the peak wavelength of a narrow window function. We have demonstrated that our proposed method is very powerful and simple for measuring chromatic dispersion and second-order dispersion in optical fibers and optical devices. Comparison of the proposed method with a conventional measurement method agrees within 0.5%.
    Applied Optics 11/2007; 46(29):7289-96. DOI:10.1364/AO.46.007289 · 1.69 Impact Factor
  • J.Y. Lee, D.Y. Kim
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    ABSTRACT: We present a novel differential mode delay (DMD) measurement method for a multimode optical fiber (MMF) based on Fourier-domain low-coherence interferometry (fLCI) for the first time. An optical spectrum analyzer and a mode scrambler were used to obtain intermodal interference signal in spectral-domain after light pass an MMF. The MMF was used as a common path interferometer by itself without using any reference arm in an interferometer. Our proposed method can measure a short or long optical multimode fiber simply, accurately, and rapidly.
    Lasers and Electro-Optics - Pacific Rim, 2007. CLEO/Pacific Rim 2007. Conference on; 10/2007
  • Endoscopy 03/2007; 39 Suppl 1:E102-3. DOI:10.1055/s-2006-945145 · 5.20 Impact Factor
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    ABSTRACT: A novel differential mode delay (DMD) measurement for a multimode optical fiber using the Fourier-domain low-coherence interferometry (fLCI) for the first time has been proposed. Our experimental results have a good agreement with those results obtained using a conventional method
    Optical Fiber Communication Conference, 2006 and the 2006 National Fiber Optic Engineers Conference. OFC 2006; 04/2006
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    ABSTRACT: To evaluate whether pre-operative chemo-radiotherapy (CRT) improves the sphincter preservation rate for distal rectal cancers within 3 cm of the anal verge. Between January 2001 and December 2004, 49 patients underwent surgery with or without pre-operative CRT for primary rectal adenocarcinoma within 3 cm of the anal verge. Clinical data were retrospectively reviewed, including stage workups, surgical records and pathology records to determine sphincter preservation rate and the factors influencing sphincter preservation. Of 49 patients with rectal tumours within 3 cm of the anal verge, 31 underwent pre-operative CRT followed by surgery (CRT group), and 18 underwent surgery alone (non-CRT group). Sphincter preservation was possible in 11 of 31 CRT patients, and only one of 18 non-CRT patients (p=0.036). The factors most influencing sphincter preservation were reduction in tumour size (p=0.005) and downstaging (p=0.001) following pre-operative CRT. We could observe that sphincter preservation was improved in CRT group with statistical significance when compared to non-CRT group in our study patients with rectal cancer within 3 cm of the anal verge.
    European Journal of Surgical Oncology 04/2006; 32(2):162-7. DOI:10.1016/j.ejso.2005.10.002 · 2.89 Impact Factor
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    S J Jung, JY Lee, DY Kim
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    ABSTRACT: A new phase-matching condition for a four-wave-mixing (FWM) experiment in an optical fiber is proposed to simultaneously measure the linear and nonlinear optical properties of an optical fiber such as dispersion-zero wavelength, dispersion slop, and nonlinear refractive index. Several different dispersion shifted fibers (DSFs) and nonzero dispersion shifted fibers (NZDSFs) were tested to demonstrate the validity of our proposed method. We have also shown that experimental results are in good agreement with those obtained using a conventional measurement method. We believe that technique is a very powerful and efficient tool for zero-dispersion and dispersion slop mapping for already installed optical fibers.
    Optics Express 02/2006; 14(1):35-43. DOI:10.1364/OPEX.14.000035 · 3.53 Impact Factor
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    ABSTRACT: Nam JH, Kim YM, Jung MH, Kim KR, Yoo HJ, Kim DY, Kim JH, Kim YT, Mok JE. Primary peritoneal carcinoma: experience with cytoreductive surgery and combination chemotherapy. Int J Gynecol Cancer 2006;16:23–28.The objective of this study was to review the clinical outcome and prognosis of patients with primary peritoneal carcinoma (PPC) treated with cytoreductive surgery and combination chemotherapy. We retrospectively reviewed the charts of 27 patients with histologically confirmed PPC, treated between March 1990 and February 2004 at Asan Medical Center, South Korea. The review included demographic data, pathologic findings, treatments, and outcomes. The mean age of the 27 patients was 57.5 ± 7.2 years, and the rate of optimal cytoreduction was 70.4%. Seven patients had stage IIIB, 17 had stage IIIC, and 3 had stage IV; all patients received adjuvant chemotherapy. There were 4 patients with progressive disease, 5 partial responders, and 15 complete responders; the remaining 3 patients were nonevaluable. At the time of the review, 10 patients were alive without evidence of disease, 3 were alive with disease, and 14 had died from disease. The median overall survival time was 41 months, and the overall 5-year survival rate was 18.1%. Patients who had optimal cytoreduction had a longer median survival (42 months) than those who had suboptimal cytoreduction (10 months; P < 0.05). Combination chemotherapy after optimal cytoreductive surgery may be effective in the treatment of patients with PPC.
    International Journal of Gynecological Cancer 01/2006; 16(1):23 - 28. DOI:10.1111/j.1525-1438.2006.00314.x · 1.95 Impact Factor
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    S. Moon, D.Y. Kim
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    ABSTRACT: We propose a novel transmission scheme to extend the single-mode operation range of a conventional single-mode fiber (C-SMF) to wavelengths shorter than the cutoff wavelength. It involves the use of a tapered-fiber mode filter (MF) in order to remove the high-order-mode power from the C-SMF and hence, makes the fiber work as a virtually single-mode transmission link. High-order mode suppression of above 10 dB has been achieved at wavelengths of 850 and 980 nm with a fabricated tapered-fiber MF. We have also demonstrated the feasibility of the technique by evaluating the transmission quality with the MF at 850 nm through a 5-km C-SMF having a cutoff wavelength of 1.2 μm.
    IEEE Photonics Technology Letters 01/2006; 17(12-17):2604 - 2606. DOI:10.1109/LPT.2005.859166 · 2.18 Impact Factor

Publication Stats

595 Citations
100.43 Total Impact Points

Institutions

  • 2006–2013
    • National Cancer Center Korea
      • Colorectal Cancer Branch
      Kōyō, Gyeonggi Province, South Korea
  • 2009
    • Kyung Hee University
      • Department of Medicine
      Seoul, Seoul, South Korea
  • 2006–2009
    • University of Ulsan
      • College of Medicine
      Urusan, Ulsan, South Korea
  • 2002–2009
    • Gwangju Institute of Science and Technology
      • School of Information and Communications
      Gwangju, Gwangju, South Korea
    • University of Illinois, Urbana-Champaign
      Urbana, Illinois, United States
    • National Veterinary Research Quarantine Service
      Sŏul, Seoul, South Korea
  • 2005
    • Sungkyunkwan University
      • Institute of Basic Science
      Sŏul, Seoul, South Korea
  • 2000–2003
    • Seoul National University
      • Department of Nuclear Engineering
      Sŏul, Seoul, South Korea
  • 2001
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Korea Institute of Science and Technology Information (KISTI)
      Daiden, Daejeon, South Korea
  • 1999
    • Seoul National University Hospital
      • Department of Surgery
      Sŏul, Seoul, South Korea