Qamar Ayesha

Osmania Medical College, Bhaganagar, Andhra Pradesh, India

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Publications (4)2.52 Total impact

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    ABSTRACT: Introduction: The excess accumulation of free fluid in the peritoneal cavity is due to its multitude causes. Certain cytological and biochemical markers are reported for the differential diagnosis of ascites. In the present study, ascitic patients with liver cirrhosis and ovarian carcinoma are investigated. Aim: To study the concentrations of certain trace elements and ceruloplasmin levels in ascitic fluid and in serum of patients with liver cirrhosis in comparison to ovarian cancer patients. Study Design: The study includes 170 patients with liver cirrhosis, 95 patients with ovarian cancer and 100 serum controls. Place and Duration of Study: The study is performed in the department of Gastroenterology, Osmania General Hospital Hyderabad, A.P, INDIA, between December 2011 to July 2013. Methodology: The trace elements such as magnesium, copper, zinc, iron and ceruloplasmin were investigated in 170 patients with liver cirrhosis (120 males, 50 females, 22-75 years; mean age 46.2±11.2) and 95 ovarian cancer patients (19-84 years; mean age 50.2±12.2). All the analysts were measured in serum and ascitic fluid by using standard commercial kits. 100 serum samples from healthy controls were also included in the study. Results: The mean serum concentrations of copper and ceruloplasmin were significantly increased in ovarian cancer patients when compared to that of liver cirrhosis and healthy controls (P<. 001, P<. 001) respectively. The mean zinc levels in serum samples were low in both the groups when compared to controls (P<. 001). The ascitic fluid zinc levels in ovarian cancer were higher when compared to that of liver cirrhosis (P<. 001). Similar results were noted in the serum iron levels in both the groups. The serum magnesium levels in liver cirrhosis are comparable to that of controls but the levels of magnesium in ovarian cancer ascitic patients are high when compared to that of controls. Conclusion: Our results showed that there are differences in trace elements and ceruloplasmin levels in liver cirrhosis and ovarian cancer patients in both serum and ascitic fluid samples. The cutoff value of copper and ceruloplasmin in serum samples are 134.5 μg/dl and 43.5 mg/dl, while in ascitic fluid were 46.5 μg/dl and 21.0 mg/dl respectively. As the diagnostic efficiency of copper and ceruloplasmin in serum and ascitic fluid samples are 97% to 99% with highest sensitivity and specificity, analysis of trace elements with ceruloplasmin in depth with their ratios may be helpful in differentiating the cirrhotic and neoplastic illness.
    British Journal of Medicine & Medical Research. 05/2014; 4(21):3902-3911.
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    ABSTRACT: Abstract Early diagnosis of peritoneal metastases from cancer patients provides better management and treatment aspects. In the present study biochemical investigations such as albumin, total proteins, lactate dehydrogenase and cholesterol in the serum and ascitic fluid aspirates were done in 46 ovarian malignant (46 females mean age 49.47±12.64 yrs) and 70 non-malignant ascites patients (54 males and 16 females mean age 49.1±10.78 yrs).The results in the fluid showed that lactate dehydrogenase, total proteins and cholesterol levels were drastically increased, while SAAG is reduced in malignant ascites when compared to non-malignant ascitic patients . The present study thus emphasizes that SAAG is still useful in the differential diagnosis of ascites. Key Words: Ascites, Differential diagnosis, Malignancy, Biochemical markers.
    International Journal of Pharmacy and Technology. 01/2013; 5(1):5136-5143.
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    ABSTRACT: The differential diagnosis of ascites is important and is cumbersome .The present study was conducted to obtain the basic biochemical data in serum and ascitic fluid of patients with non-malignant ascites; These parameters utilize it for confirming the underlying causative factors for ascites.The parameters analyzed were liver enzymes (SGPT, SGOT and ALP), Adenosine deaminase (ADA), Creatinine, Amylase, Lactate dehydrogenase (LDH), Total proteins and albumin. A total of 69 patients with non- malignant ascites (55 Males and 14 Females mean age 49 + 12 years) were studied over a period of one year. Involvement of liver disease was noted in 47 patients (68%), while the rest of the patients had peritoneal tuberculosis ( 7 cases – 10% ), nephrotic syndrome ( 9 cases -13% ) and pancreatic ascites ( 6 cases -9%).Biochemical analysis of the results with Lactate dehydrogenase, proteins and albumin data showed that SAAG (Serum ascites albumin gradient) is still the best criteria for the differential diagnosis of ascites.The present study emphasize the SAAG is useful marker for diagnosis of different ascites , and it will useful for the evaluation and diagnosis of malignant ascites.
    International Journal of Science Innovations and Discoveries. 02/2012; 2(1):72-76.
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    ABSTRACT: Gastric cancer is a multifactorial disease with the involvement of both genetic and environmental risk factors. Genetic variation in genes encoding cytokines and their receptors determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. Transforming growth factor (TGF-β) signaling pathway plays an important role in the genesis and progression of tumors through regulating cell proliferation and differentiation. A hospital-based case-control study was conducted to investigate whether TGF-β1 -509 C/T polymorphism can modify the risk of gastric cancer. Seventy endoscopically and histopathologically confirmed gastric cancer patients and 100 age and sex-matched healthy controls were enrolled in the case-control study. TGF-β1 -509 C/T gene polymorphism was carried out by amplification refractory mutation system polymerase chain reaction (ARMS-PCR) method followed by agarose gel electrophoresis. Statistical analysis was applied to test for the significance of the results. The distribution of TGF-β1 genotypes at -509 C/T were CC 37.14%, CT 50%, and TT 12.86% in gastric cancer patients and CC 52%, CT 42%, and TT 6% in control subjects. The allelic frequencies of C and T were 0.621 and 0.379 in gastric cancer patients and 0.73 and 0.27 in control subjects, respectively. Our study imply that T allele of TGF-β1 -509 C/T genotypes may be a risk factor of genetic susceptibility to gastric cancer in south Indian population.
    Tumor Biology 10/2011; 32(5):1049-53. · 2.52 Impact Factor

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7 Citations
2.52 Total Impact Points

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Institutions

  • 2011–2013
    • Osmania Medical College
      Bhaganagar, Andhra Pradesh, India