David Wood

University of Western Australia, Perth City, Western Australia, Australia

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Publications (25)68.52 Total impact

  • Mark Edmondson · Jay Ebert · Oscar Nivbrant · David Wood ·
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    ABSTRACT: Aims To accurately assess subsidence, rotation and clinical scores in two cementless femoral stems. Methods 260 patients received either K2 or Apex femoral stems and were studied over 2y, with RSA and clinical scores. Results Mean Oxford Hip score for both stems was excellent (45.78 and 46.76). Very little subsidence or rotation were noted on RSA in either stem. There were no statistically significant differences in clinical scores, or radiological motion between stems. Revision rate was 0.8% over the study period. Conclusion Excellent clinical and RSA scores over the 2y study period predict good long term outcomes for these stems.
    Journal of Orthopaedics 06/2014; 11(2). DOI:10.1016/j.jor.2014.02.001
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    ABSTRACT: Matrix-induced autologous chondrocyte implantation (MACI) has become an established technique for the repair of chondral defects in the knee. MACI has traditionally required an open arthrotomy, though now lends itself to an arthroscopic technique, which may decrease the associated co-morbidity of arthrotomy, potentially allowing for faster rehabilitation. To compare post-operative outcomes between arthroscopic and open-arthrotomy techniques of MACI and present a case for faster recovery and accelerated rehabilitation following surgery. Retrospective Cohort Study. Private functional rehabilitation facility. 78 patients (41 arthroscopic, 37 open) treated with MACI for full-thickness cartilage defects to the femoral condyles. According to surgeon preference, patients recruited over the same time period underwent MACI performed arthroscopically or via a conventional open arthrotomy. Both surgical groups were subjected to an identical rehabilitation protocol. Patient-reported (KOOS, SF-36 and VAS) and functional (six minute walk test, three-repetition straight leg raise test) outcomes were compared pre-surgery and at 3, 6 and 12 months post-surgery. Active knee range of motion (ROM) was additionally assessed at 4 and 8 weeks post-surgery. MRI evaluation was assessed using magnetic resonance observation of cartilage repair tissue (MOCART) scores at 3 and 12 months. The length of hospital stay was evaluated, while post-surgery complications were documented. Significant improvements (p<0.05) for both groups were observed over the 12-month period for patient-reported and functional outcomes; however, the arthroscopic cohort performed significantly better (p<0.05) in active knee flexion and extension ROM, and the three-repetition straight leg raise test. No differences were observed in MOCART scores between the two groups at 12 months. Patients who received arthroscopic implantation required a significantly reduced (p<0.001) hospital stay, and experienced less post-operative complications. Arthroscopic MACI in combination with 'best practice' rehabilitation has shown encouraging early results, with good clinical outcomes to 12 months, reduced length of patient hospitalization and reduced risk of post-surgery complications. This may have important implications on post-operative rehabilitation and a faster return to full function.
    Journal of Sport Rehabilitation 04/2014; 23(3). DOI:10.1123/jsr.2013-0042 · 1.28 Impact Factor
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    ABSTRACT: Matrix-induced autologous chondrocyte implantation (MACI) has become an established technique for the repair of full thickness chondral defects in the knee. Until recently, the implantation of these grafts was only possible via an open mini-arthrotomy. However, while the MACI technique permits an arthroscopic approach and several arthroscopic techniques have now been described, limited published work has been reported on the early post-operative outcome and associated benefits following an arthroscopic approach. This study presents the early clinical and radiological outcomes to 12 weeks in patients treated with arthroscopic MACI, compared with a matched-control patient cohort undergoing MACI through a standard open mini-arthrotomy within the same time period, highlighting the potential benefits of arthroscopically performed MACI.
    Arthroscopy The Journal of Arthroscopic and Related Surgery 10/2013; 29(10, Supplement):e170. DOI:10.1016/j.arthro.2013.07.248 · 3.21 Impact Factor
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    Arthroscopy The Journal of Arthroscopic and Related Surgery 10/2013; 29(10-10):e178-e179. DOI:10.1016/j.arthro.2013.07.247 · 3.21 Impact Factor

  • Arthroscopy The Journal of Arthroscopic and Related Surgery 10/2011; 27(10):e176-e177. DOI:10.1016/j.arthro.2011.08.159 · 3.21 Impact Factor
  • Greg Janes · David Wood ·

    Cartilage Surgery. An Operative Manual, First edited by Mats Brittbery and Wayne Gersoff, 01/2011: chapter Autologous Chondrocyte Implantation. Matrix-Induced Autologous Chondrocyte Implantation (MACI): pages 161-173; Elsevier Saunders., ISBN: 978-1-4377-0878-3
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    Simon Garrett · Neal Jacobs · Piers Yates · Anne Smith · David Wood ·
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    ABSTRACT: Ions are released from all metals after implantation in the body through processes of corrosive and mechanical wear. The aim of this study was to investigate whether serum metal ion levels are raised in patients following total knee arthroplasty. Serum levels of chromium, cobalt, aluminium, molybdenum and zirconium were measured in two groups of patients at a minimum of 3 years after knee arthroplasty. Twenty three patients had a cobalt-chromium femoral component and 14 patients had an oxidized zirconium femoral component, acting as a control group as this femoral component is free from cobalt and chromium. All patients had the same titanium tibial base plates, and no patellae were resurfaced. Despite the lack of cobalt and chromium in the prostheses used in the control group, no statistically significant differences in serum cobalt and chromium ion levels were found between the groups. On the basis of these results there does not appear to be any significant rise in serum metal ion levels following total knee arthroplasty several years after implantation.
    Acta orthopaedica Belgica 08/2010; 76(4):513-20. · 0.65 Impact Factor
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    ABSTRACT: Hemiarthroplasty is a well-established treatment for displaced subcapital fracture, but controversy exists about the optimal implant type. Bipolar hemiarthroplasty has proposed advantages over unipolar hemiarthroplasty in terms of better clinical results and decreased wear of acetabular cartilage. This study is a randomized prospective study of 51 patients (52 hips) receiving either bipolar or unipolar hemiarthroplasty for displaced subcapital fractures. The outcome measurements were clinical scores and Roentgen stereophotogrammetric analysis (RSA) analysis to determine the rate of acetabular wear. Twenty-three patients completed 2-year follow-up. The RSA data demonstrated that there was slightly less acetabular wear by bipolar prostheses than by unipolar. The combined mean three-dimensional wear of the bipolar prostheses was 0.6 mm compared with 1.5 mm for the unipolar prostheses (P= 0.04). The bipolar group generally achieved higher scores in terms of the Harris Hip Score, Western Ontario and McMaster University Index of Osteoarthritis (WOMAC) questionnaire and 6-min walk test. These results were statistically significant at 3 months but not at 12 and 24 months. This study suggests that while the bipolar prosthesis performs slightly better than the unipolar in terms of acetabular cartilage wear and clinical outcomes, it remains debatable whether the benefits are worth the increased cost of the prosthesis.
    ANZ Journal of Surgery 04/2010; 80(4):242-6. DOI:10.1111/j.1445-2197.2009.05040.x · 1.12 Impact Factor

  • Current Orthopaedic Practice 10/2009; 20(5):575-578. DOI:10.1097/BCO.0b013e3181a0ab61
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    ABSTRACT: An abstract is unavailable. This article is available as HTML full text and PDF.
    Transplantation 10/2008; 86(5):746-8. DOI:10.1097/TP.0b013e318183f7aa · 3.83 Impact Factor
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    Tuuli Saari · Ming Guo Li · David Wood · Bo Nivbrant ·
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    ABSTRACT: A few studies have shown that cementing the stem enhances fixation of the tibial baseplate in total knee replacement (TKR). Even the horizontal technique has been shown to provide good fixation. We used radiostereometry to study migration of the tibial component in 30 knees operated with Profix TKR. The knees were randomised for either complete (both under the baseplate and around the stem) or horizontal (only under the baseplate) cementing of the tibial component. At two years the tibial baseplate rotated externally a median of 0.18 degrees in the uncemented stem group and internally a median of 0.23 degrees in the cemented stem group. The tibial baseplate subsided 0.14 mm in the cemented stem group, and no translation was seen in the uncemented stem group. The differences in migration were small and probably without clinical significance. The findings do not favour either of the cementing techniques in TKR.
    International Orthopaedics 09/2008; 33(5):1239-42. DOI:10.1007/s00264-008-0632-x · 2.11 Impact Factor
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    ABSTRACT: Chondrocyte phenotype has been shown to dedifferentiate during passaged monolayer cultivation. Hence, we have investigated the expression profile of 27 chondrocyte-associated genes from both osteoarthritic cartilage tissue and healthy passaged human articular chondrocytes by quantitative real-time PCR. Our results indicate that the gene expression levels of matrix proteins and proteases in chondrocytes from monolayer culture decrease compared with those from cartilage tissue, while monolayer cultured chondrocytes from normal and osteoarthritic cartilage exhibit similar gene expression patterns. However, chondrocytic gene expression profiles were differentially altered at various stages of passage. The expression of the matrix proteins aggrecan, type II collagen, and fibromodulin inversely correlated with increasing passage number, while fibronectin and link protein exhibited a marked increase with passage. The expression of matrix proteinases MMP-3/9/13 and ADAMTS-4/5 decreased with passage, whereas proteinase inhibitors TIMP-2/3 were elevated. The cytokine IL-1 also showed increased expression with monolayer chondrocyte culture, while IGF-1 expression levels were diminished. No significant changes in TGF-beta, or the chondrogenic transcription factors Sox-9, c-fos, or c-jun were observed. Our data indicates that cultured chondrocytes undergo dedifferentiation during monolayer culture, although the gene expression level of transcription factors necessary for chondrogenesis remains unchanged. This data may prove important for the future development of more specific and efficacious cultivation techniques for human articular chondrocyte-based therapies.
    Journal of Orthopaedic Research 09/2008; 26(9):1230-7. DOI:10.1002/jor.20523 · 2.99 Impact Factor
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    ABSTRACT: Screening of musculoskeletal tissue donors with nucleic acid testing (NAT) for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) has been implemented in the United States and other developed nations. However, in contrast to the donor demographics in the United States, the majority of Australian musculoskeletal tissue donations are primarily from living surgical donors. The objective of our study was to determine and compare the risk of viral infection associated with musculoskeletal tissue donation from living and nonliving donors in Australia. We studied serum samples from 12 415 consecutive musculoskeletal tissue donors between 1993 and 2004. This included 10 937 surgical donations, and 1478 donations obtained from postmortem organ donation patients and cadaveric donors. Current mandatory retesting of surgical donors 6 months postdonation reduces the risk of viral infection by approximately 95% by eliminating almost all donors in the window period. The addition of nucleic acid amplification testing for nonliving donors would similarly reduce the window period, and consequently the residual risk by approximately 50% for hepatitis B virus, 55% for HIV, and 90% for HCV. NAT, using appropriately validated assays for nonliving donors, would reduce the residual risk to levels comparable to that in living donors (where the 95% reduction for quarantining pending the 180-day re-test is included).
    Transplant International 07/2008; 21(10):936-41. DOI:10.1111/j.1432-2277.2008.00703.x · 2.60 Impact Factor
  • Felix Yao · Clive Seed · David Wood · Ming-Hao Zheng ·

    Annals of internal medicine 06/2008; 148(10):792-4. · 17.81 Impact Factor
  • Wan Mei Ang · Piers Yates · Peter Robbins · David Wood ·
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    ABSTRACT: Schwannomas (neurilemmomas) are benign neoplasms composed of well-differentiated Schwann cells and are usually found in the soft tissues. The occurrence of schwannomas in bone is rare, accounting for less than 0.2% of primary bone tumors. Most cases of osseous schwannoma reported in the world medical literature involve bones of the skull. Only 2 cases have previously been described in the tibia, neither of which has recurred. We report the first case of a recurrent benign solitary intraosseous schwannoma of the tibia, and detail the clinical, radiological and histological findings.
    Orthopedics 03/2008; 31(2):176. DOI:10.3928/01477447-20080201-03 · 0.96 Impact Factor
  • Riaz J K Khan · Felix Yao · Mingguo Li · Bo Nivbrant · David Wood ·
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    ABSTRACT: Higher dislocation rates have been reported with the posterior approach to the hip. Empirical studies suggest that careful repair of the posterior structures significantly reduces this risk. However, studies examining the integrity of repair using plain radiographs and metallic markers have reported high failure rates. To explain this discrepancy, we performed a study using radiostereometric analysis to assess the repair. Ten patients were recruited. Markers were placed into the capsule and bone. The capsule and conjoined short external rotators were repaired through drill holes in bone. At 3 months, stress radiostereometric analysis radiographs were taken in internal and external rotation. Eight of 10 patients had a mean of 3.51-mm difference in separation, suggesting that the repair was intact. We recommend careful repair of posterior structures when using the posterior approach to reduce the risk of dislocation.
    The Journal of Arthroplasty 10/2007; 22(6):840-3. DOI:10.1016/j.arth.2006.08.009 · 2.67 Impact Factor
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    ABSTRACT: Matrix-induced autologous chondrocyte implantation (MACI) has been a treatment of cartilage injury since 2000, but little is known of the histological paradigm of tissue regeneration after implantation. MACI is a stable cell-based delivery system that enables the regeneration of hyaline-like cartilage. From a cohort of 56 MACI patients, we examined the phenotype of chondrocytes seeded on type I/III collagen scaffold, and conducted progressive histologic assessment over a period of 6 months. Chondrocyte-seeded collagen scaffolds from patient implants were analyzed by electron microscopy, immunohistochemistry (type II collagen and S-100), and reverse transcription polymerase chain reaction (RT-PCR) (aggrecan and type II collagen). Coincidental cartilage biopsies were obtained at 48 hours, 21 days, 6 months, 8 months, 12 months, 18 months, and 24 months. Our data showed that chondrocytes on the collagen scaffold appeared spherical, well integrated into the matrix, and maintained the chondrocyte phenotype as evidenced by aggrecan, type II collagen, and S-100 expression. Progressive histologic evaluation of the biopsies showed the formation of cartilage-like tissue as early as 21 days, and 75% hyaline-like cartilage regeneration after 6 months. This preliminary study has suggested that MACI may offer an improved alternative to traditional treatments for cartilage injury by regenerating hyaline-like cartilage as early as 6 months after surgery.
    Tissue Engineering 05/2007; 13(4):737-46. DOI:10.1089/ten.2006.0246 · 4.25 Impact Factor
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    ABSTRACT: One hundred four hips in 107 patients undergoing revision arthroplasty of the hip were identified at risk of dislocation and treated with the constrained cup. Radiostereometric analysis was performed to assess prosthesis migration. Mean follow-up was 3.0 years (range, 2.0-4.8). At last review, 19 patients had died and 6 were lost to follow-up. There were 5 revisions for cup loosening and a further 4 with radiographic evidence of loosening. There were 3 dislocations and 3 dissociations in 5 patients. Radiostereometric analysis demonstrated that cup migration at 24 months was up to 0.82 mm of translation and 1.58 degrees of rotation. Our results confirm that the constrained acetabular component is a highly effective option for the treatment for patients with instability of the hip. The aseptic loosening rate was higher than previously reported.
    The Journal of Arthroplasty 04/2007; 22(3):377-82. DOI:10.1016/j.arth.2006.04.020 · 2.67 Impact Factor
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    ABSTRACT: Analyzing skeletal kinematics with radiostereometric analysis (RSA) following corrective orthopedic surgery allows the quantitative comparison of different implant designs. The purpose of this study was to validate a technique for dynamically estimating the relative position and orientation of skeletal segments using RSA and single plane X-ray fluoroscopy. Two micrometer-based in vitro phantom models of the skeletal segments in the hip and knee joints were used. The spatial positions of tantalum markers that were implanted into each skeletal segment were reconstructed using RSA. The position and orientation of each segment were determined in fluoroscopy images by minimizing the difference between the markers measured and projected in the image plane. Accuracy was determined in terms of bias and precision by analyzing the deviation between the applied displacement protocol and measured pose estimates. Measured translational accuracy was less than 100 microm parallel to the image plane and less than 700 microm in the direction orthogonal to the image plane. The measured rotational error was less than 1 degrees . Measured translational and rotational bias was not statistically significant at the 95% level of confidence. The technique allows real-time kinematic skeletal measurements to be performed on human subjects implanted with tantalum markers for quantitatively measuring the motion of normal joints and different implant designs.
    Journal of Biomechanics 02/2007; 40(3):686-92. DOI:10.1016/j.jbiomech.2006.01.012 · 2.75 Impact Factor

Publication Stats

433 Citations
68.52 Total Impact Points


  • 2003-2014
    • University of Western Australia
      • • School of Sport Science, Exercise and Health
      • • Centre for Orthopaedic Research (COR)
      Perth City, Western Australia, Australia
  • 2010
    • Sir Charles Gairdner Hospital
      Perth City, Western Australia, Australia