D. H. Lee

Korea Centers for Disease Control and Prevention, Daiden, Daejeon, South Korea

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Publications (367)946.47 Total impact

  • Journal of Geophysical Research: Space Physics 04/2015; DOI:10.1002/2015JA020985 · 3.44 Impact Factor
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    ABSTRACT: Eupatilin, a pharmacologically active flavone derived from Artemisia species, is known to have antioxidant and anti-inflammatory activities. Ischemia-reperfusion injury (IRI) is a major complication after renal transplantation, with inflammatory responses to IRI exacerbating the resultant renal injury. In the present study, we investigated whether eupatilin exhibits renoprotective activities against ischemia-reperfusion-induced acute kidney injury in mice. Renal IRI was induced in male C57BL/6 mice by bilateral renal pedicle occlusion for 30 minutes followed by reperfusion for 48 hours. Eupatilin (10 mg/kg body weight p.o.) was administered 4 days before IRI. Treatment with eupatilin significantly decreased neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 levels in urine, blood urea nitrogen level, and serum creatinine levels, as well as kidney tubular injury. Western blotting indicated that eupatilin significantly increased the levels of heat shock protein 70 and B-cell lymphoma protein, and it attenuated inducible nitric oxide synthase, Bcl-2-associated X protein, and caspase-3 levels 48 hours after IRI. Our findings suggest that eupatilin is a promising therapeutic agent against acute ischemia-induced renal damage. Copyright © 2015 Elsevier Inc. All rights reserved.
    Transplantation Proceedings 04/2015; 47(3):757-62. DOI:10.1016/j.transproceed.2014.12.044 · 0.95 Impact Factor
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    ABSTRACT: We report measurements of the Diffuse Galactic Light (DGL) spectrum in the near-infrared, spanning the wavelength range 0.95-1.65 {\mu}m by the Cosmic Infrared Background ExpeRiment (CIBER). Using the low-resolution spectrometer (LRS) calibrated for absolute spectro-photometry, we acquired long-slit spectral images of the total diffuse sky brightness towards four high-latitude fields spread over four sounding rocket flights. To separate the DGL spectrum from the total sky brightness, we correlated the spectral images with a 100 {\mu}m intensity map, which traces the dust column density in optically thin regions. The measured DGL spectrum shows no resolved features and is consistent with other DGL measurements in the optical and at near-infrared wavelengths longer than 1.8 {\mu}m. Our result implies that the continuum is consistently reproduced by models of scattered starlight in the Rayleigh scattering regime with a few large grains.
  • AGU Fall Meeting, San Francisco, 15-19 December 2014; 12/2014
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    ABSTRACT: We have examined relativistic electron flux losses at geosynchronous orbit under quiet geomagnetic conditions. One 3-day period, from 11 to 13 October 2007, was chosen for analysis because geomagnetic conditions were very quiet (3-day average of Kp <1), and significant losses of geosynchronous relativistic electrons were observed. During this interval, there was no geomagnetic storm activity. Thus, the loss processes associated with geomagnetic field modulations caused by ring current buildup can be excluded. The >2 MeV electron flux at geosynchronous orbit shows typical diurnal variations with a maximum near noon and a minimum near midnight for each day. The flux level of the daily variation significantly decreased from first day to thirdday for the 3-day period by a factor of >10. The total magnetic field strength (BT) of the daily variation on the third day, however, is comparable to that on the first day. Unlike electron flux decreases, the flux of protons with energies between 0.8 and 4 MeV adiabatically responses to the daily variation of BT. That is, there is no significant decrease of the proton flux when the electron flux decreases. During the interval of quiet geomagnetic conditions, well-defined electromagnetic ion cyclotron (EMIC) waves were detected at geosynchronous spacecraft. Low-altitude polar orbiting spacecraft observed the precipitation of energetic protons and relativistic electrons in the interval of EMIC waves enhancement. From these observations, we suggest that the EMIC waves at geosynchronous orbit cause pitch-angle scattering and relativistic electron losses to the atmosphere under quiet geomagnetic conditions.
    Journal of Geophysical Research: Space Physics 10/2014; 119(10). DOI:10.1002/2014JA020234 · 3.44 Impact Factor
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    ABSTRACT: For 2-d X-ray imaging, such as mammography and non-destructive test, a sensor should have a large-area because the sensor for typical X-ray beams cannot use optical lens system. To make a large-area 2-d X-ray image sensor using crystal Si, a technique of tiling unit CMOS image sensors into 2 × 2 or 2 × 3 array can be used. In a unit CMOS image sensor made of most common 8-inch Si wafers, the signal line can be up to ~ 180 mm long. Then its parasitic capacitance is up to ~ 25 pF and its resistance is up to ~ 51 kΩ (0.18 μm, 1P3M process). This long signal line may enlarge the row time up to ~ 50 μsec in case of the signal from the top row pixels to the readout amplifiers located at the bottom of the sensor chip. The output signal pulse is typically characterized by three components in sequence; a charging time (a rising part), a reading time and a discharging time (a falling part). Among these, the discharging time is the longest, and it limits the speed or the frame rate of the X-ray imager. We proposed a forced discharging method which uses a bypass transistor in parallel with the current source of the column signal line. A chip for testing the idea was fabricated by a 0.18 μm process. A active pixel sensor with three transistors and a 3-π RC model of the long line were simulated together. The test results showed that the turning on-and-off of the proposed bypass transistor only during the discharging time could dramatically reduce the discharging time from ~ 50 μsec to ~ 2 μsec, which is the physically minimum time determined by the long metal line capacitance.
    Journal of Instrumentation 08/2014; 9(08):P08011. DOI:10.1088/1748-0221/9/08/P08011 · 1.53 Impact Factor
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    ABSTRACT: BACKGROUND: Classic galactosemia (OMIM #230400) is an autosomal recessive metabolic disorder caused by a deficiency of the galactose-1-phosphate uridyltransferase (GALT, EC2.7.7.12) protein due to mutations in the GALT gene. The aim of this study was to provide a comprehensive and updated mutation spectrum of GALT in a Korean population. METHODS: Thirteen unrelated patients screened positive for galactosemia in a newborn screening program were included in this study. They showed a reduced GALT enzyme activity in red blood cells. Direct sequencing of the GALT gene and in silico analyses were done to evaluate the impact of novel variations upon GALT enzyme activity. We also reviewed previous reports for GALT mutations in Koreans. RESULTS: We identified six novel likely pathogenic variations including three missense (p.Ala101Asp, p.Tyr165His, and p.Pro257Thr), one small deletion/insertion [c.826_827delinsAA (p.Ala276Asn)], one frameshift (p.Asn96Serfs*5), and one splicing (c.378-1G > C) likely pathogenic variations. The most frequent variation was the Duarte variant (c.940A > G, 35.3%), followed by c.507G > C (p.Gln169His, 9.6%), among 34 Korean patients. Other mutations were widely scattered. None of the eight common mutations used for targeted mutation analysis in Western countries including p.Gln188Arg, p.Ser135Leu, p.Lys285Asn, p.Leu195Pro, p.Tyr209Cys, p.Phe171Ser, c.253-2A > G, and a 5 kb deletion, had been found in Koreans until this study. CONCLUSIONS: Considering the mutation spectrum in Koreans, direct sequence analysis of entire GALT exons is recommended for accurate diagnosis. The mutations responsible for GALT deficiency in the Korean population were clearly different from those of other populations.
    BMC Medical Genetics 08/2014; 15(1):94. DOI:10.1186/s12881-014-0094-5 · 2.45 Impact Factor
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    ABSTRACT: When an interplanetary (IP) shock passes over the Earth's magnetosphere, the geosynchronous magnetic field strength near noon is always enhanced except for the magnetopause crossing events. Near midnight, however, it increases or decreases. This indicates that the nightside magnetosphere is not always compressed by a sudden increase in the solar wind dynamic pressure. To understand midnight geosynchronous magnetic field responses to IP shocks, we statistically examined geosynchronous magnetic field perturbations, corresponding to 120 sudden commencements (SCs), observed when geosynchronous spacecraft were near midnight between 2200 and 0200 magnetic local times. Out of the 120 SCs, 107 SCs were identified by one geosynchronous spacecraft, and 13 SCs were identified by two geosynchronous spacecraft. Thus, 133 events were used in our statistical study. We observed 23 events in spring, 40 events in summer, 32 events in fall, and 38 events in winter, respectively. A statistical study of the midnight geosynchronous SC perturbations reveals the following characteristics. (1) In summer, all events show a positive enhancement (+ΔBT) in the magnetic field strength. (2) In winter, however, ΔBT exhibits a positive (+ΔBT) or negative (−ΔBT) enhancement. (3) In summer, the midnight geosynchronous SC perturbations in the BH component (positive northward) in VDH coordinates are mostly (~88%, 35 out of 40 events) positive (+ΔBH), while the occurrence rate of the positive perturbation (~43%) in the Bz component (positive northward) in GSM coordinates is lower than that of the negative perturbation (~57%). (4) In winter, the negative perturbations in ΔBH (~61%) and ΔBz (~74%) are dominant. (5) Both the north-south components (BH and Bz) in spring and fall are scattered around zero. To explain the observations we suggest that SC-associated cross-tail current (JSC) has a peak intensity around geosynchronous orbit thus is a main controlling factor of midnight geosynchronous magnetic field perturbations during SCs. Specifically, we suggest that the seasonal variation of the sign of ΔBH, ΔBz, and ΔBT is due to the seasonal variation of the spacecraft position relative to JSC.
    Journal of Geophysical Research: Space Physics 06/2014; 119(6). DOI:10.1002/2013JA019380 · 3.44 Impact Factor
  • D. H. Lee, K. S. Min, J.-H. Kang
    Water Science & Technology 05/2014; 69(10):2122. DOI:10.2166/wst.2014.125 · 1.21 Impact Factor
  • Journal of Hepatology 04/2014; 60(1):S404. DOI:10.1016/S0168-8278(14)61148-X · 10.40 Impact Factor
  • European Urology Supplements 04/2014; 13(1):e1069-e1069a. DOI:10.1016/S1569-9056(14)61050-2 · 3.37 Impact Factor
  • Journal of Hepatology 04/2014; 60(1):S372-S373. DOI:10.1016/S0168-8278(14)61056-4 · 10.40 Impact Factor
  • Journal of Hepatology 04/2014; 60(1):S217. DOI:10.1016/S0168-8278(14)60607-3 · 10.40 Impact Factor
  • European Urology Supplements 04/2014; 13(1):e988. DOI:10.1016/S1569-9056(14)60972-6 · 3.37 Impact Factor
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    ABSTRACT: To compare long-term survival after hepatic resection and transarterial chemoembolization of large solitary hepatocellular carcinomas (HCCs). Analysis of 91 and 68 consecutive patients with large (≥ 5 cm) solitary HCCs who underwent hepatic resection and transarterial chemoembolization, respectively, was performed. Overall survival and time to progression (TTP) were estimated using the Kaplan-Meier method and compared using the Cox proportional hazards model. To control for treatment-selection bias, matched groups of patients were selected using a propensity score matching method, and survival analysis was repeated. During the follow-up period (median, 60.7 mo; range, 0.5-122.2 mo), 42 (46%) patients in the hepatic resection group and 35 (51%) patients in the transarterial chemoembolization group died. The 1-year, 3-year, and 5-year overall survival rates of the hepatic resection and transarterial chemoembolization groups were 91.1%, 80.0%, and 66.4% (hepatic resection group) and 89.8%, 72.8%, and 49.6% (transarterial chemoembolization group) (P = .023). TTP was significantly longer in patients who underwent hepatic resection (P < .001). Hepatitis B surface antigen positivity and the absence of portal hypertension were independent predictors for favorable overall survival. For patients with platelet counts ≤ 100,000/mm(3), Child-Pugh score of 6, smaller HCCs (≤ 7 cm), or portal hypertension, hepatic resection and transarterial chemoembolization yielded similar overall survival rates. After propensity score matching, transarterial chemoembolization was comparable to hepatic resection in overall survival (P = .293), whereas TTP remained longer in patients who underwent hepatic resection (P = .001). Transarterial chemoembolization can lead to results comparable to hepatic resection in the treatment of large solitary HCCs, particularly in patients with clinically presumed portal hypertension. Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.
    Journal of Hepatology 04/2014; 60(1):S398. DOI:10.1016/S0168-8278(14)61128-4 · 10.40 Impact Factor
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    ABSTRACT: Polymorphisms near the interleukin (IL) 28B gene have been proposed to be associated with spontaneous clearance of the hepatitis C virus. The purpose of this study was to assess the relationship between IL28B polymorphisms and the rate of spontaneous hepatitis B surface antigen (HBsAg) seroclearance by means of meta-analysis. MEDLINE/PubMed and EMBASE were utilized to identify relevant studies. Odds ratio (OR) and 95% confidence interval (CI) were analysed together to assess the strength of the association. Subgroup analyses were mainly performed according to ethnicity. A total of 4028 cases with persistent chronic hepatitis B and 2327 spontaneously recovered controls were included from 11 studies. The single nucleotide polymorphism (SNP), rs12979860, had no significant association with HBsAg seroclearance (OR = 0.98, 95% CI: 0.84-1.14 in the dominant model; OR = 1.00, 95% CI: 0.68-1.46 in the recessive model; and OR = 0.95, 95% CI: 0.82-1.09 in the allelic model). The SNP, rs12980275, had no significant association either (OR = 1.03, 95% CI: 0.84-1.26 in the dominant model; OR = 1.17, 95% CI: 0.46-2.96 in the recessive model; and OR = 1.04, 95% CI: 0.86-1.26 in the allelic model), nor did the SNP, rs8099917 (OR = 0.94, 95% CI: 0.77-1.15 in the dominant model; OR = 0.74, 95% CI: 0.34-1.62 in the recessive model; and OR = 0.93, 95% CI: 0.77-1.13 in the allelic model). Similarly, the results of subgroup analyses by ethnicity also showed no association in either the Asian group or non-Asian group. We concluded that there was no significant association between common IL28B polymorphisms and the rate of spontaneous HBsAg seroclearance.
    Journal of Viral Hepatitis 03/2014; 21(3):163-70. DOI:10.1111/jvh.12193 · 3.31 Impact Factor
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    ABSTRACT: Purpose A national organ transplant registry is an indispensable organizational requirement for patient care, research, and planning. Even though the Korean Network for Organ Sharing (KONOS) has established a database for a waiting list, organ allocation, and incidence of organ transplantation since 2000, an integrated registry including post-transplantation data is needed for better understanding of organ transplantation. Recently, the Korean Society for Transplantation (KST) and the Korean Center for Disease Control (KCDC) designed a web-based organ transplant registry, named the Korean Organ Transplant Registry (KOTRY). As an initial project of KOTRY, we retrospectively analyzed kidney transplantations (KTs) performed in 2009 and 2010. Methods A total of 2292 KTs (91.9%) from 46 hospitals (80.7%) were collected and analyzed. Ninety-five elements related to KT were selected and analyzed. Results Proportions of male recipients and retransplantations were 58.4% and 7.1%, respectively. Even though glomerulonephritis was the most common cause of end-stage renal disease (ESRD) (28.4%), the number of diabetic nephropathy cases was increasing. The living donor (LD) to deceased donor (DD) ratio was 1.69:1. Because of a serious organ shortage in Korea, DD kidneys with a low initial estimated glomerular filtration rate (eGFR) of <45 mL/min/1.73 m2 (21.2%) and expanded criteria donors (ECDs; 18.3%) are frequently used. Other noticeable findings are the increasing number of wife donors and ABO-incompatible (ABOi) transplants for O+ recipients. Conclusions The epidemiological profile of transplantation is different from country to country. The number of organ transplantations in East Asian countries is rapidly growing, however, there are few epidemiological data about this region in the literature. With the establishment of KOTRY, it was possible to present the first nationwide epidemiological data of Korean KTs.
    Transplantation Proceedings 03/2014; 46(2):425–430. DOI:10.1016/j.transproceed.2013.11.083 · 0.95 Impact Factor
  • Clinical Genetics 02/2014; DOI:10.1111/cge.12350 · 3.65 Impact Factor
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  • S H Park, S Jeong, D H Lee
    Endoscopy 01/2014; 46 Suppl 1:E240-1. DOI:10.1055/s-0033-1344589 · 5.20 Impact Factor

Publication Stats

2k Citations
946.47 Total Impact Points

Institutions

  • 2014
    • Korea Centers for Disease Control and Prevention
      Daiden, Daejeon, South Korea
  • 2012–2014
    • Soonchunhyang University
      Onyang, South Chungcheong, South Korea
    • Kyungpook National University
      • Institute For Phylogenomics and Evolution
      Daikyū, Daegu, South Korea
  • 2008–2014
    • Seoul National University Hospital
      • • Department of Dermatology
      • • Department of Radiology
      Sŏul, Seoul, South Korea
    • Korea Research Institute of Bioscience and Biotechnology KRIBB
      • Medical Proteomics Research Center
      Anzan, Gyeonggi Province, South Korea
    • Hanyang University
      • Department of Biomedical Engineering
      Sŏul, Seoul, South Korea
  • 2006–2014
    • Korea Advanced Institute of Science and Technology
      • • Department of Nuclear and Quantum Engineering
      • • Department of Materials Science and Engineering
      • • Department of Physics
      Sŏul, Seoul, South Korea
    • Sun Moon University
      Onyang, Chungcheongnam-do, South Korea
  • 2002–2014
    • Kyung Hee University
      • • School of Space Research
      • • Department of Astronomy and Space Science
      • • Graduate School of East-West Medical Science
      Sŏul, Seoul, South Korea
  • 1999–2014
    • Inha University Hospital
      Sinhyeon, South Gyeongsang, South Korea
  • 2011–2013
    • University of California, San Diego
      • Department of Physics
      San Diego, California, United States
    • Korea Atomic Energy Research Institute (KAERI)
      Daiden, Daejeon, South Korea
    • Seoul Women's University
      • College of Natural Sciences
      Sŏul, Seoul, South Korea
    • California Institute of Technology
      • Division of Physics, Mathematics, and Astronomy
      Pasadena, California, United States
    • Korea Electrotechnology Research Institute-KERI
      Tsau-liang-hai, Busan, South Korea
  • 2007–2013
    • Yonsei University
      • Department of Urology
      Sŏul, Seoul, South Korea
    • National Cancer Center Korea
      Kōyō, Gyeonggi Province, South Korea
  • 2005–2013
    • University of Ulsan
      • • College of Medicine
      • • Department of Radiology
      Urusan, Ulsan, South Korea
    • National Institute of Health Sciences, Japan
      • Division of Microbiology
      Edo, Tōkyō, Japan
    • Gangneung Asan Hospital
      Sŏul, Seoul, South Korea
  • 2003–2013
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2007–2012
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 1998–2012
    • Inha University
      • • Department of Chemistry
      • • Department of Internal Medicine
      Chemulpo, Incheon, South Korea
    • Korea Institute of Industrial Technology
      Anzan, Gyeonggi Province, South Korea
  • 1995–2012
    • Seoul National University
      • • Department of Physics and Astronomy
      • • Department of Medicine
      Sŏul, Seoul, South Korea
  • 2010–2011
    • Chonbuk National University
      • Department of Electrical Engineering
      Tsiuentcheou, Jeollabuk-do, South Korea
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
  • 2007–2011
    • Seoul National University Bundang Hospital
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2008–2010
    • Ewha Womans University
      Sŏul, Seoul, South Korea
  • 2006–2010
    • Korea Astronomy and Space Science Institute
      • Division of Space Science
      Daiden, Daejeon, South Korea
  • 2003–2010
    • Pohang University of Science and Technology
      • • Department of Chemistry
      • • Department of Electronic and Electrical Engineering
      Geijitsu, North Gyeongsang, South Korea
  • 2009
    • Pusan National University
      Tsau-liang-hai, Busan, South Korea
    • Chungnam National University
      • College of Veterinary Medicine
      Daiden, Daejeon, South Korea
    • Hannam University
      • Department of Biological Sciences
      Daiden, Daejeon, South Korea
    • Chonnam National University
      Gwangju, Gwangju, South Korea
    • Samsung Medical Center
      • Department of Gastroenterology
      Sŏul, Seoul, South Korea
  • 2007–2009
    • Asan Medical Center
      • Department of Neurology
      Sŏul, Seoul, South Korea
  • 2007–2008
    • Catholic University of Korea
      Sŏul, Seoul, South Korea
  • 2000–2008
    • Sungkyunkwan University
      • • Samsung Medical Center
      • • School of Medicine
      • • School of Advanced Materials Science and Engineering (AMSE)
      Sŏul, Seoul, South Korea
  • 2004
    • University of Seoul
      • Department of Life Science
      Sŏul, Seoul, South Korea
  • 1985–1989
    • University of Florida
      • Department of Electrical and Computer Engineering
      Gainesville, Florida, United States