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ABSTRACT: We evaluated the levels of atrial natriuretic factor (ANF) in amniotic fluid and in maternal venous blood in pregnancies with fetal cardiac malformations and chromosomal abnormalities.
Between the 16th and 18th week of pregnancy, 151 women were divided into three groups. Group A included patients at lowest risk, carrying a fetus with a normally developing heart and normal karyotype (control group). Group B included women with a fetus suffering from cardiac malformations, with or without associated chromosomal abnormalities. Group C included women carrying a fetus affected with chromosomal abnormalities without congenital cardiopathies. ANF was evaluated by radioimmunoassay.
In maternal venous blood, the mean levels of ANF were 42.1, 53.1 and 38.7 pg/ml in groups A, B and C, respectively. In amniotic fluid, the mean levels of ANF were 34.2, 101.8 and 35.8 pg/ml in groups A, B and C, respectively. In group A (control group) there was no statistical difference in ANF levels across the gestational age range of 16-18 weeks, either in amniotic fluid or in maternal venous blood. A significant difference of ANF content in maternal venous blood was revealed in comparing group A with group B (p < 0.01), and group C with group B (p < 0.01). A statistically significant difference in ANF levels was also found in amniotic fluid between group A and group B (p < 0.01), and between group C and group B (p < 0.01). No statistically significant differences were found between group C and group A in comparing ANF levels in maternal venous blood and amniotic fluid.
ANF levels in amniotic fluid and in maternal venous blood are increased early in the case of fetuses with cardiac malformations, with or without associated karyotype alteration. Chromosomally abnormal fetuses without heart malformations have normal ANF levels. These results could be useful for elucidating fetal pathophysiology mechanisms.
Journal of Maternal-Fetal and Neonatal Medicine 03/2002; 11(3):183-7. · 1.50 Impact Factor
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Journal of Telemedicine and Telecare 02/2001; 7(2):119-20. · 1.21 Impact Factor
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ABSTRACT: Hydatidiform mole with coexistent fetus is an unusual entity caused by two distinct types of pregnancy: the first one is a partial hydatidiform mole, while the second is a twin pregnancy in which a mole coexists with a normal fetus. In these two separate genetic entities, the counseling and the mother-fetus prognosis are different. Two cases of mole with coexistent fetus are reported: a partial hydatidiform mole typically tripliod and a partial mole with unusual diploid karyotype. Prenatal diagnosis is remarkable for the evaluation of fetus development related with his karyotype. Triplody excludes all hope of a non-malformed surviving child and termination of pregnancy is desirable, while normal karyotype the possibility of a continuation of pregnancy may be considered.
Minerva ginecologica 07/2000; 52(6):253-7.
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ABSTRACT: The aim of this study is to determine the rate of vertical transmission of hepatitis C and to analyse the concomitant infection by HIV as a risk factor.
We have studied the perinatal transmission of HCV in 22 pregnancies: 14 in women HCV+/HIV-, 8 in women HCV+/HIV+. We have performed the following tests on sera: test RIBA II to search for Ab anti-HCV, alanine transaminase (ALT) evaluation and HCV-RNA research by PCR. These tests were performed on sera from infants at birth and, then, during one year every three months.
Within one year Ab anti-HCV disappeared in 20 of 22 pregnancies: two infants positive by Ab anti-HCV were born to HIV+ mothers and they were the only two who showed abnormal ALT values and detectable levels of HCV-RNA. Finally 10 of 14 infants born to HCV+/HIV- mothers were breast-fed and none was infected.
We conclude that HCV mother-to-child transmission is an uncommon event, breast-milking is safety, and the concomitant infection by HIV could represent a risk factor for vertical transmission of hepatitis C.
Minerva ginecologica 05/1999; 51(4):117-9.
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ABSTRACT: Among the pregnant patients who underwent an amniocentesis at our department of prenatal diagnosis (Division of Gynecology and Obstetrics of the University "Federico II" in Naples) from 1989 to 1996, 16 patients were affected by non-immune hydrops faetalis associated with chromosomal diseases.
The karyotype test revealed at an ultrasound exam of the fetus that 11 cases were affected by trisomy 21, 4 cases by Turner syndrome and one case by trisomy 18. This study took into consideration all the pathogenetic factors and the diagnostic problems of non-immune hydrops faetalis in fetus affected by associated chromosomal associated anomalies.
Since the incidence of the chromosomal anomalies on fetus affected by non-immune hydrops foetal is was very high, there was the necessity to carry out a routine karyotype test if the ultrasonography revealed anomalies of the hydrops, during the first three months of pregnancy.
Minerva ginecologica 01/1998; 49(12):535-9.
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ABSTRACT: From January 1992 to March 1996, 1987 women underwent vaginal sonography screening, at the Department of Obstetrics and Gynaecology of the II Faculty of Medicine and Surgery "Federico II" in Naples. This mass screening aimed at early diagnosis of ovarian cancer.
Patients included in this investigations were all asymptomatic and had no pelvic abnormalities. Each ovary was measured in three planes and ovarian volume was calculated using the prolate ellipsoid formula. In premenopausal women, ovaries were normal if their volume was of > or = 18 cm3 and if they were hypoechogenic or anechogenic. In postmenopausal women a normal ovary was defined as having a volume of > or = 8 cm3 and a uniformly hypogenic internal structure.
In thirty-five premenopausal women was detected an abnormal volume of the ovaries. Forty-six postmenopausal women had abnormal vaginal sonograms. In this investigations vaginal sonography has permitted the detection of about 4.88% ovarian tumors in asymptomatic women, so that, it can be considered a more accurate and direment screening method for ovarian cancer than abdominal sonography.
Minerva ginecologica 06/1997; 49(6):243-9.
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ABSTRACT: Essential thrombocythemia is a rare disease of unknown etiology characterized by an abnormal increase in the platelet count which cannot be explained by other identifiable causes such as malignancy, infection, chronic inflammatory diseases or other myeloproliferative disorders. It rarely affects people less than 50 years of age and may be associated with hemorrhagic or thrombotic tendencies. A care of pregnancy complicated by essential thrombocythemia treated with aspirin, antiaggregating agent, throughout pregnancy and with hydroxyurea, a platelet lowering drug is reported. Also examine are some pathogenetic and therapeutic aspects of the thrombotic tendency secondary to elevated platelet count in pregnancy.
Minerva ginecologica 05/1997; 49(4):165-72.
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ABSTRACT: 80 patients underwent ultrasound guided cyst puncture of ovarian cysts. Six patients were pregnant and in four of them needle aspiration was executed through the transvaginal tract. The sediment aspirated was examined by a cytologic method and when possible it was also correlated to a histological test. Technique and results have been dealt with. No relevant complication was found. Finally, the echoguided (induced) needle aspiration is a simple and safe method to treat benign ovarian cysts in fertile women. It is particularly advisable in pregnancy and in patients for whom both laparascopy and traditional surgery are not practicable.
Minerva ginecologica 01/1995; 46(12):663-70.
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ABSTRACT: The clinical effects were studied of two different PGE analogues on the uterine motility and cervical ripening of eighty pregnant women asking for a second trimester elective abortion for fetal abnormalities. Forty women received vaginal suppositories each containing 1 milligram of 16, 16-dimethyl-trans-s2-PGE1 (Gemeprost) every 3 hours (5 mg max). Intramuscular injections of 500 micrograms of 16-phenoxy-w 17, 18, 19, 20 tetranor PGE2 methyl-sulphonylamide (Sulprostone) were administered every four hours (2000 mcg max.) to the remaining forty patients. Thirty-three Gemeprost treated patients (82.5%) and 34 Sulprostone treated patients (85%) experienced a complete abortion in the mean of 12.92 +/- 6.95 hours and 11.88 +/- 6.8 hours respectively. The histological and ultrastructural findings of cervical ripening were similar in both groups, while the tocographic patterns showed different characteristics. Side effects occurred in 16 Sulprostone (40%), but only in 9 (22.5%) Gemeprost treated patients, demonstrating that Gemeprost, although equally effective, is better tolerated.
Clinical and experimental obstetrics & gynecology 02/1991; 18(4):251-9. · 0.43 Impact Factor
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ABSTRACT: Ultrasound assessment of septum thickness is useful in twin pregnancies for predicting the type of placentation. In fact, its greater or lesser acoustic resonance distinguishes monochorionic or dichorionic pregnancies. This makes adoption of therapeutic measures more secure in the event of pathology involving only one of the two fetuses.
Minerva ginecologica 03/1989; 41(2):75-7.
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ABSTRACT: The Authors treated twenty-eight women using IUD, who suffered from increased menstrual blood loss and pelvic pain, with a prostaglandin synthetase inhibitor, Suprofen, in an attempt to reduce their symptomatology, in a double blind crossover study. The drug produced an important reduction of the menstrual blood loss and pains. These observations suggest that prostaglandins are involved in the etiology of excessive menstrual blood loss and pains, and that prostaglandin inhibitors may be useful for reducing these symptoms.
Clinical and experimental obstetrics & gynecology 02/1987; 14(1):41-4. · 0.43 Impact Factor
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Minerva ginecologica 01/1981; 32(12):1120-3.
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Minerva ginecologica 01/1981; 32(12):1125-30.
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Minerva ginecologica 11/1980; 32(10):881-6.
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ABSTRACT: Non-immune hydrops fetalis (NHF) has become, with the decrease in frequency of rhesus-isoimmunization during the last years, an important aspect of modern obstetrics in consideration of the increased diagnostic and therapeutic means now available. Some cases of NHF with particular etiology (viral twin-twin transfusion syndrome, malformations) are reported and the necessity of a multidisciplinary specialistic approach for the resolution of diagnostic and prognostic problems of this serious complication of pregnancy is underlined.
Minerva ginecologica 50(1-2):31-7.
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Archivio di ostetricia e ginecologia 86(3-4):161-6.
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Archivio di ostetricia e ginecologia 86(3-4):167-75.
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Archivio di ostetricia e ginecologia 86(5-6):189-94.
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Archivio di ostetricia e ginecologia 86(5-6):211-6.
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Archivio di ostetricia e ginecologia 86(5-6):223-31.
