[Show abstract][Hide abstract] ABSTRACT: Digitalization of the HTV News Programme has changed the techniques used so far for archiving the AV material. Access to the server now gives archivists more independency in their work and also a more direct contact with the work of journalists (raw material and semi–finalized products). This has made possible a more creative approach to archiving, which is one of the crucial aspects of the production, required at the end of production, but often at its beginning as well. Digitalization enables the creation of on–line archives – the Workspace within the scope of the Media Manager. The archives are created from the existing analogue material entered into the server and from the material that is already on the server, which – due to its (most often) use value – needs to be part of the Workspace Archives. As a result, the archives are divided in the so – called »legacy« (existing, inherited) and »born« (newly established) archives. The first ones contain materials from the old media and their access to the digital world is possible only by migration. The other archived material is available on the server upon direct ingestion, or transfer from the digital storage. Its content may never be copied and physically handled. Instead, it will remain stored for the virtual availability to users.
[Show abstract][Hide abstract] ABSTRACT: The rate of genome damage elimination after therapeutic exposure to ionising radiation was estimated in stage I testicular seminoma patients monitored over a seven-year follow-up. DNA damage elimination in peripheral lymphocytes of ten subjects was analysed by the chromosome aberration assay. Seven years after the end of radiotherapy, signifi cantly increased frequency of ring and dicentric chromosomes was still detected in comparison with baseline values. These results indicate the induction of genome instability. Long-term follow-up studies of cancer patients after radiotherapy could give us valuable information on the rate of genome damage elimination after exposure to ionising radiation and about the duration and manifestation of genome instability. This may be used in health risk assessment related to the possible development of secondary neoplasia. Studies such as this could have a great value both for oncology and radiation protection management protocols, especially after accidental overexposures.
Archives of Industrial Hygiene and Toxicology (email@example.com); Vol.62 No.1. 01/2011;
[Show abstract][Hide abstract] ABSTRACT: This study attempts to answer the question if any level of head and neck circulation takes a part in development of Age-Related Macular Degeneration (ARMD) and hearing and equilibrium impairments. Condition of large blood vessels was examined by Color-Doppler ultrasound, and carotid and ophthalmic arteries were included. The microcirculatory changes were examined directly by fundus photography and fluorescein angiography and indirectly testing hearing and equilibrium. The study group included 40 patients (21 females, 19 males) aging from 53 to 84 years with different stages of ARMD. The control group included 40 patients (18 females, 22 males) aging from 51 to 82 years without ARMD. Patients were inhabitants of Primorsko-Goranska County. There was no relationship between ARMD and condition of large blood vessels because significant stenosis of carotid arteries was found in 2 patients (5%) in study group and 3 patients (7.5%) in the control group (p>0.05). On the contrary, we found correlation between ARMD and hearing (p=0.0127) and equilibriium impairments (p=0.0242). Fluorescein angiograms shows raised number of ischemic retinal capillaries in patients with ARMD (p=0.0053). Results lead to conclusion that circulatory disorders on microcirculatory level take a great part in development of ARMD and hearing and equilibrium impairments in the elderly. The key is damage of sensory cells of the retina and inner ear caused by microcirculatory disorders. Interesting data was noticed that 9 patients with more serious ARMD on one side of head had greater hearing loss on the same side. If we find a new treatment for microcirculatory disorders, maybe we can treat both sensory impairments in earlier stage.
Collegium antropologicum 04/2010; · 0.61 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Aim: The aim is to determine possible advantage of application of Tramadolum, Diclofenacum and Dexamethasonum in therapy of postoperative pain after lumbar discectomy in relation to standard postoperative application of Tramadolum and Metamizolum Natricum. Methods: The research covered 46 patients with mean age of 45.29 ± 14.06. All patients underwent open lumbar discectomy. The first group, consisting of 23 patients, was treated with Tramadolum and after the surgery , and the other one, also with 23 patients, was treated with Tramadolum, Dexamethasonum and Diclofenacum. The VAS questionnaire of postoperative pain consisted of two parts: the first one, filled in by a surgeon, included clinical findings, and the second one, filled in by a patient, contained data entered by the patient on postoperative pains and painful discomforts two and eight days after the surgery, with the scale from 0 to 10. Statistical 5.0 programme was used in statistical analysis. Statistical significance of differences was determined by Student’s independent samples T-test, while significance of differences between individual samples in respect of pain and time of filling in the questionnaire was determined by Student’s dependent samples T-test. Results: The research results, not considering measurement of preoperative pain, show that the group treated with Tramadolum, Dexamethasonum and Diclofenacum experienced significantly lower pain in the leg area (p< 0.01), while pain in sacral area was somewhat lower but still with statistical significance (p = 0.03; p = 0.01) compared to the group receiving Tramadolum and Metamizolum Natricum. Conclusion: The research results confirm efficiency and advantage of combined therapy with Tramadolum, Diclofenacum and Dexamethasonum in coping with postoperative pain after lumbar discectomy compared to the therapy with Tramadolum and Metamizolum Natricum.
[Show abstract][Hide abstract] ABSTRACT: Aim: The goal was to analyze hip joint by RTG before and after the surgery and to find out the real difference in leg length as well as to determine the position of the femoral part of endoprosthesis. Material and methods: 40 patients had implanted noncement endoprosthesis and another 40 cement endoprosthesis. Data were calculated for the period from 1.1.2007. to 31.12.2008., retrospectively. Results: In our research, upon implanting noncement prosthesis 26 of examined patients had longer leg after the procedure, but none had the deviations larger than 2 centimeters. Furthermore, 4 had shorter leg, and 10 had equal leg length before and after the surgery. 92 % of all patients had Intraplant type endoprosthesis implanted and remaining 8 % had Zimmer type endoprosthesis. Intraplant endoprosthesis were mostly implanted in valgus position – 18 cases, 10 were implanted in varus position and 9 in neutral position. In Zimmer case however 2 endoprosthesis were implanted in valgus position and 1 in neutral position. In case of cement endoprosthesis implantation 34 of patients had on leg longer, two of them deviation more than 2 cm. One patient had shorter leg and in 5 cases the length of leg were not changed before and after the surgery. 75 % of all patients had implanted Surgival endoprosthesis and 21,5 % of them had Zimmer and ZweiMuller endoprosthesis. 50 % of Surgival endoprosthesis were implanted in valgus position of phemoral part, 30 % in neutral position and remaining 20 % in varus position. In Zimmer case 50 % of all endoprosthesis were implanted I neutral position of femoral component. Conclusion: One of main goals of total hip arthroplasty is a complete reconstruction of normal hip biomechanics which influence longevity of endoprosthesis. Leg length discrepancy is one of the potential complications after total hip arthroplasty that can affect patient satisfaction with the operation. Although, sometimes it is not possible to fully reconstruct the normal hip biomechanics, proper preoperative preparation, and appropriate positioning of femoral components can significantly affect the leg length discrepancy.
[Show abstract][Hide abstract] ABSTRACT: Age-related maculopathy (ARM) is one of the leading causes of central visual acuity loss in older western population. Many factors are responsible for the fast development of ARM. One of this is significant increases of optical radiations through artificial lens after removal of the catarctous lens. The aim of this study was to compare progression of ARM in phakic and pseudophakic patients and to calculate the possibility of pseudophakia as a risk factor for faster progression of ARM. Medical records of 76 patients, older than 60 years (32 male and 44 female) with early forms of ARM were randomly evaluated. They had undergone cataract removal by phacoemulsification with intraocular lens implantation from January 2002 to December 2006 at the Department of Ophthalmology, Rijeka University Hospital, Croatia. Patients were examined two weeks after the surgery and followed up for two years. The control group consisted of 48 patients (21 males and 27 females) with also early forms of ARM, older than 60 years, examined at the Policlinic Department from January 2006 to December 2006 and followed up at least for two years without any cataract surgery. Comparing progression of ARM in these two groups, a total of 19 patients (25%) in pseudophakic group showed progression to late forms of ARM, but only 6 patients (12.5 %) in the control group developed these aggressive ARM forms. More aggressive forms of ARM in pseudophakic group indicate that pseudophakia should be considered as a risk factor for development of ARM.
Collegium Antropologicum (firstname.lastname@example.org ); Vol.34 supplement 2 No.2. 01/2010;
[Show abstract][Hide abstract] ABSTRACT: To determine the optimal ploughing depth and to make tillage simpler and less costly, but also taking account of edaphic and climatic conditions as well as biological and agrotechnical requirements of crops grown, long-term investigations (1994-2009) have been carried out on Stagnic Luvisol of sloping terrains in central Croatia near Daruvar. The paper presents the results relating to plant density and yields of maize (Zea mays L.), soybean (Glycine max L.), oilseed rape (Brassica napus L.), winter wheat (Triticum aestivum L.) and spring barley (Hordeum vulgare L.). Investigation results point to the conclusion that high density crops (winter wheat, spring barley and oilseed rape) are suitable for growing under reduced tillage systems. Yields of low density spring crops (maize and soybean) obtained under the no-tillage system are not satisfactory, especially in climatically extreme years.
[Show abstract][Hide abstract] ABSTRACT: Assay interferences have long been underestimated and unfortunately too often undetected in the daily clinical laboratory practice. The extra-analytical phase of the laboratory testing process has been recognized as the major source of laboratory errors over the past decade. Preanalytical errors are most common errors within the total testing process and hemolysis is recognized as one of the most prevalent preanalytical errors and surely the most prevalent interference in clinical laboratory testing. Visual detection of hemolysis is arbitrary and therefore mostly unreliable since it may over- and underestimate the actual prevalence of hemolyzed serum specimens (i.e., trained observers are unable to accurately rank the degree of interference in serum). Elevated concentration of bilirubin may further impair the ability to detect hemolysis by visual inspection and therefore lead to serious underestimation of hemolysis in neonatal samples where elevated bilirubin concentration is commonplace. The recent advances in laboratory technology have lead to an increasing trend in the automation of various preanalytical processes into large preanalytical modules. Such modules as well as novel automated laboratory analyzers offer the automated detection of serum indices. This is advantageous due to the increased reproducibility and the improvement in detection of mildly hemolyzed specimens (serum hemoglobin < 0.6 g/L). These platforms commonly use the semiquantitative spectrophotometric measurement and grade interfering substances into several categories. However, various analytical platforms may have different decision thresholds for various serum indices. Moreover, different systems might be different in their assay parameters and the degree of the interference of the specific interfering substance. Therefore, more efforts should be focused to standardize the mean of reporting the hemolysis index, especially when this important parameter is used for obtaining meaningful information on the quality of sample collection throughout collection centers and wards. Hemolysis is still one of the biggest challenges to the laboratory specialists. In case of hemolysis, laboratory personnel should always ask for new sample(s). In case new sample(s) can not be obtained, it is the responsibility of the laboratory specialist to communicate the problem with the physician responsible for the patient and seek for the solution to the best of the patient care.
[Show abstract][Hide abstract] ABSTRACT: The aim of this study is to evaluate the content of phenolics: total phenols (TPC), flavonoids (TF), anthocyanins (TA), flavan-3-ols (TF3ols), as well as total antioxidant capacity (TAC) and reducing power (RP) in four blueberry cultivars (Vaccinium corymbosum L.) introduced in the Northwest Croatian climate conditions. Phenolic compounds were measured by spectrophotometric methods, TAC was determined using DPPH and ABTS assays and RP by FRAP assay. All cultivars contained high mass fraction of TPC, TF, TA and lower mass fraction of TF3ols. Among the researched fruits, Sierra cultivar contained the highest amounts of all groups of phenolics, followed by Elliott>Bluecrop≥Duke. Significant differences were observed in phenolic mass fraction among different cultivars and growing seasons (p<0.05), and phenolic compounds were significantly higher in growing season 2006. Examined cultivars possess high antioxidant capacity and reducing power, and all phenolics were highly correlated with TAC and RP (R=0.46 to 0.99). The study indicated that growing and climate conditions in Northwest Croatia are convenient for introducing blueberry cultivars. Generally, blueberry fruits are a rich source of phenolics, which show evident antioxidant capacity.
Food Technology and Biotechnology (email@example.com); Vol.48 No.2. 01/2010;
[Show abstract][Hide abstract] ABSTRACT: Lichen planus is a chronic immunologic inflammatory disease that frequently involves oral mucosa. Systemic diseases and medications are considered to be precipitating factors in the development of oral lichen planus. Objective: The purpose of this study was to examine the prevalence of systemic diseases and medications in patients with oral lichen planus (OLP) and to determine possible causal relationship. Materials and methods: Retrospective data included medical records of 145 patients, 104 women and 41 men who were referred to the Department of Oral Medicine. All patients had clinical and histopathological criteria fulfilled for diagnosis of oral lichen planus. Data were collected for the period of two years (autumn 2007- autumn 2009). These data were compared with the prevalence of systemic diseases in patients with oral leukoplakia (LPL) and general Croatian population according to the national statistical register. The same comparison was made for the used medications. Obtained data were analyzed by use of χ2 test with level of significance p<0,05. Results: Systemic diseases associated with OLP were found in 77.9% of patients. The most frequent disease was hypertension. Frequency of systemic diseases between patients with OLP and LPL has shown statistically significant difference. Conclusion: Increased prevalence of hypertension among OLP patients in comparison to the prevalence in the general population can not be interpreted as the etiological factor for the development of OLP since hypertension is the most prevalent disease in general population.
[Show abstract][Hide abstract] ABSTRACT: PTSD is a complex psychobiological disorder that couses disfunctionality in many areas. In treating PTSD different models have been applied, however, no general consensus on the method of treatment has yet been achieved. At the Clinic for Psychol.ogical Medicine we have developed the model of combined treatment for PTSD patients that involves outpatient individual psychoterapy, psychopharmacotherapy and group psyhoterapeutic techniques introduced within repeated day-hospital treatments. In this paper the efficiency of the above mentioned model has been explored. Three PTSD patients have been presented. We assessed changes in psychological functioning of our subjects on the basic of clinical observation and analasys of the session protocols. The model of combined and long-term treatment of PTSD in which the approach to traumatised patients has been mostly supportive, including supportive psychoterapeutic interventions and psychoaromatherapy, has proved to be efficient in achieving integration of traumatic experiences and consolidation of traumatised Self. Combination of individual and group approach facilitates the analisys of traumatic transference, whereas more mature defence patterns become stronger and integration of traumatic experiences improved. Consolidation of the Self leads to better socilization.
[Show abstract][Hide abstract] ABSTRACT: Tourism as one of the most distinct modern socio-economical phenomena of the world in its quantitative indicators is approaching gradually in the framework of international relations to billions of participants, with the economic effects that exceed the 800 billion USD. These sizes are almost triplicate by inclusion of domestic tourist migration, which gives more impressive social and economic dimension to a whole figure. It is logical that this movement with their economic effects are accomplishing 30% of world trade exchanges, 17% GDP, 12% of employment, 7% of investments, through direct, conversion or multiplier effects includes almost all spheres of modern economic and social superstructure and are manifesting very expressive with their positive but also possible negative connotations to the sociological and especially on the spatial sphere. Today very actual and extended mutual interactions between tourism, health and health culture in the modern society in this topic shall be analyzed considering two basic aspects and they are the following: - Influence of level of health culture in the area of tourist initiative about making decision on joining the tourist migration as the important element of health preservation, and the quality of living, being familiar with all medical advantages in temporary changing working and living environment.. - Influence of health tourism as polyfunctional social phenomenon on the health of tourists and the level of health and social culture of certain area where it is developed in the context of accompanying possible negative consequences of intensive tourist development on the environment space and social sphere.
[Show abstract][Hide abstract] ABSTRACT: Introduction: Extra-analytical phase is the source of most of the errors in laboratory practice. A cross-sectional survey study was performed among members of Croatian Chamber of Medical Biochemists (CCMB) aimed to investigate the status of extra-analytical phase in Croatia. Materials and methods: Results were collected from members of CCMB (N = 538) using anonymous questionnaire with 20 Likert scaled questions testing self-reported frequency (never = 1, rarely = 2, often = 3, always = 4) of procedures of the pre-analytical phase. Answers were expressed as average score ranging from 1.00 to 4.00 for all questions. Questions were further divided in three groups, which average score was calculated accordingly: criteria of acceptance of sample, procedures of phlebotomy, test results reporting. Question on recording of nonconformities was separately evaluated. Results: The response rate was 27%. Subject were 93% women, 58% medical biochemists with master degree and 42% specialist in medical biochemistry. Type of institution and informatics skills were also recorded. The average overall score was (mean ± standard deviation) 3.12 ± 0.38. There was no difference regarding type of laboratory institution, professional degree or computer skills and no correlation between score and age. Procedures of phlebotomy score (2.83 ± 0.46) achieved the lowest (P < 0.001) out of the three scores calculated (criteria of acceptance of sample: 3.33 ± 0.49; reporting of results 3.19 ± 0.48). Twenty one percent of participants never or rarely record nonconformities, whereas 79% often or always do. Conclusion: Results clearly highlight the urgent need for improving activities in the extra-analytical phase, especially phlebotomy procedures. Reinforced education of all the personnel involved, appropriate recording and monitoring of extra-analytical phase is necessary to reach high quality standards.
[Show abstract][Hide abstract] ABSTRACT: A new Common Market Organisation (CMO) for fruit and vegetables is in place from 1 January 2008. First debate about reform was lunched in 2004 by European Commission and its publication about simplification of the Fruit and Vegetable Common Market Organisation. The last extensive reform in 1996 introduced modifications like a plan for the progressive reduction of support for short-term market intervention and the strengthening of structural aid to improve competitiveness in order to help producers to develop their capacity and to adapt to market demand. The most important reasons for the new reform of CMO for fruit and vegetables are imbalance in the supply and distributions chain, limited influence of the producers’ organisations, coherence with rural development aid and the questions of standards. The objective of this paper is to explore the regulatory framework of the European Common market organisation for fruit and vegetables, reasons and aims of the reform and to compare the Croatian legislation regarding fruit and vegetables sector with the EU CMO for fruit and vegetables. The qualitative research strategy which emphasizes words rather than quantification in the collection and analysis of data and has an inductive approach to the relationship between theory and research is used to make conclusions in this paper. The conclusions about the objectives are made by studying the reference literature related to the topic of the EU Fruit and Vegetables Common market organisation, assumptions derived from the research and professional knowledge related to the topic.
[Show abstract][Hide abstract] ABSTRACT: Contrary to group A b-hemolytic streptococcus as the most common cause of postinfectious glomerulonephritis (PIGN), Epstein-Barr virus (EBV) is only occasionally associated with acute renal involvement. We describe an 11-year-old boy who presented with clinical signs of infective mononucleosis and acute glomerulonephritis characterized by edema, hypertension and dark colored urine with diminished renal function. Serology tests confirmed streptococcal infection and acute EBV infection. Persistently depressed C3 complement and gross hematuria indicated renal biopsy which shows PIGN-type picture and, in addition, acute interstitial nephritis, both conclusive of streptococcal infection. We performed tissue DNA extraction by polymerase chain reaction (PCR) and demonstrated EBV-DNA from the kidney specimen supporting EBV involvement in renal tissue. This is the first reported case of PIGN with serologically-proven streptococcal and simultaneously, acute EBV co-infection. EBV-DNA extraction supported the EBV involvement in renal tissue suggesting that both etiologic agents might have contributed to renal inflammation. Adding serology evaluation for EBV in cases with typical clinical signs of infective mononucleosis and renal symptoms, EBV might be more commonly associated with PIGN than is currently appreciated.
Collegium Antropologicum (firstname.lastname@example.org ); Vol.34 supplement 2 No.2. 01/2010;
[Show abstract][Hide abstract] ABSTRACT: A systematic review and meta-analysis suggests that around 2% of scientists admit to have falsified research at least once (1). Up to 33% admit other questionable practices such as plagiarism, duplicate publication, undisclosed changes in pre-research protocols or dubious ethical behavior (1). There can be no doubt that discovered cases of research and publication misconduct represent a tip of an iceberg and many cases go unreported (2). Experienced biomedical journal editors are aware of a “rogues’ gallery” of major fraudsters, such as Schoen, Hwang, Sudbo, Poehlman, Singh, and Chandra (3-8). Much more common are the less dramatic, because more subtle but probably more dangerous, examples; these are more dangerous because they remain undiscovered so may feed into meta-analyses and guidelines. A seminar organized by the Esteve Foundation, held in Sitges in April 2009, concentrated on conflicts of interest (COI, sometimes also referred to as Competing Interests, CI), which underlie so much research and publication misconduct. All attendants of the meeting agreed that there were many sources of COI in the general process of scientific communication (Figure 1). The meeting was mainly focused on non-financial COI. Three introductory presentations highlighted some of the topics related to COI in the contemporary scientific publishing enterprise.
Croatian Medical Journal (email@example.com); Vol.51 No.1. 01/2010;
[Show abstract][Hide abstract] ABSTRACT: Aim To investigate whether intra-personal variation in serum uric acid concentration is influenced by genes that were described to be associated with serum uric acid levels in cross-sectional studies. Methods The study included 92 participants from the isolated community of the Croatian island of Vis. For each participant, two uric acid concentration measurements were available, one from 2002 and one from 2003. Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Results Thirteen participants (14%) had uric acid concentration change greater than 130 μmol/L. Greater variability of uric acid concentration was recorded in women (coefficient of variation 49% vs 12% in men). Two single-nucleotide polymorphisms (SNP) belonging to SLC17A3 gene (rs9393672 and rs942379) yielded significant association with serum uric acid concentration changes in women. These two SNPs explained 0.2%-1.3% of variance for 2002 or 2003 uric acid measurement and 1.1%-1.8% of variance for the average value of these two measurements. Conclusions Repeated measurements offer a possibility to enrich the percent of explained variance and contribute to the understanding of the “missing heritability” concept. Although a number of genes have been shown to affect serum uric acid concentration, SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation.
Croatian Medical Journal (firstname.lastname@example.org); Vol.51 No.1. 01/2010;