Charloteaux B

Publications (2)62.4 Total impact

• Article: Evidence for Network Evolution in an Arabidopsis Interactome Map

  Braun P, Carvunis AR, Charloteaux B, Dreze M, Ecker JR, Hill DE, Roth FP, Vidal M, Galli M, Balumuri P, [......], Przulj N, Rabello S, Rietman EA, Rolland T, Santhanam B, Schmitz RJ, Spooner W, Stein J, Vandenhaute J, Ware D
  Science 07/2011; · 31.20 Impact Factor
• Article: Evidence for network evolution in an Arabidopsis interactome map

  Braun P, Carvunis AR, Charloteaux B, Dreze M, Ecker JR, Hill DE, Roth FP, Vidal M, Galli M, Balumuri P, [......], de los Reyes C, Gilles P, Kim CJ, Matrubutham U, Mirchandani J, Olivares E, Patnaik S, Quan R, Ramaswamy G, Sw Shinn P
  [show abstract] [hide abstract]
  ABSTRACT: Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
  Science 01/2011; 333:601. · 31.20 Impact Factor