C Williams

University of Leeds, Leeds, England, United Kingdom

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Publications (4)13.06 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: P>Background Some of the cytokines that have effects on melanogenesis are also reported to be involved in psoriasis. Objectives We therefore studied the relationship between psoriasis and melanocytic naevi. In particular, the aim of our study was to investigate the number of melanocytic naevi in patients with psoriasis vs. controls. Methods We performed a prospective case-control study, analysing 93 adult patients with psoriasis and 174 adult aged-matched controls. For each participant a questionnaire was completed to establish personal data, personal medical history, and personal and familial history of skin cancer and psoriasis. We analysed interleukin (IL)-1 alpha, IL-6 and tumour necrosis factor (TNF)-alpha gene expression at the peripheral blood mononuclear cell level in patients with psoriasis and in controls. Results In our study, patients with psoriasis presented a lower number of areas with naevi in comparison with controls (P < 0 center dot 0001). Nobody had ever had squamous cell carcinoma or melanoma in the psoriatic group; moreover, there was a significant difference in familial history of melanoma between the two groups (none in the psoriatic group vs. 8% in the control group; P < 0 center dot 05). IL-1 alpha, IL-6 and TNF-alpha expression levels were higher in patients with psoriasis. Conclusions People with psoriasis had fewer melanocytic naevi. This suggests that the proinflammatory cytokine network in psoriasis skin might inhibit melanogenesis, melanocyte growth and/or progression to naevi.
    British Journal of Dermatology 02/2011; 164(6):1311-5. DOI:10.1111/j.1365-2133.2011.10246.x · 4.10 Impact Factor
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    ABSTRACT: Healthcare-associated infection is an important worldwide problem that could be reduced by better hand hygiene practice. However, irritant contact dermatitis of the hands as a result of repeated hand washing is a potential complication that may be preventable by the regular use of an emollient. To assess the effect of moisturizer application after repeated hand washing (15 times daily) vs. soap alone. In a double-blind, randomized study, the effect of five different moisturizers on skin barrier function was determined by assessment after repeated hand washing over a 2-week period in healthy adult volunteers. Assessments of transepidermal water loss (TEWL), epidermal hydration and a visual assessment using the Hand Eczema Severity Index (HECSI) were made at days 0, 7 and 14. In total, 132 patients were enrolled into the study. A statistically significant worsening of the clinical condition of the skin as measured by HECSI was seen from baseline to day 14 (P = 0.003) in those subjects repeatedly washing their hands with soap without subsequent application of moisturizer. No change was seen in the groups using moisturizer. Subclinical assessment of epidermal hydration as a measure of skin barrier function showed significant increases from baseline to day 14 after the use of three of the five moisturizing products (P = 0.041, 0.001 and 0.009). Three of the five moisturizers tested led to a statistically significant decrease in TEWL at day 7 of repeated hand washing. This effect was sustained for one moisturizing product at day 14 of hand washing (P = 0.044). These results support the view that the regular application of moisturizers to normal skin offers a protective effect against repeated exposure to irritants, with no evidence of a reduction in barrier efficiency allowing the easier permeation of irritant substances into the skin as has been suggested by other studies. Regular use of emollient in the healthcare environment may prevent the development of dermatitis.
    British Journal of Dermatology 03/2010; 162(5):1088-92. DOI:10.1111/j.1365-2133.2010.09643.x · 4.10 Impact Factor
  • C Williams · A M Layton · K Kerr · C Kibbler · R C Barton
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    ABSTRACT: We report a case of cutaneous alternariosis in an immunocompetent 85-year-old man. Identification of the causative organism in this patient was achieved by 18S rRNA sequencing. A 6-month course of itraconazole led to a good clinical response.
    Clinical and Experimental Dermatology 08/2008; 33(4):440-2. DOI:10.1111/j.1365-2230.2007.02664.x · 1.23 Impact Factor
  • C Williams · J Thompstone · M Wilkinson
    Contact Dermatitis 02/2008; 58(1):62-3. DOI:10.1111/j.1600-0536.2007.01169.x · 3.62 Impact Factor

Publication Stats

46 Citations
13.06 Total Impact Points

Institutions

  • 2010
    • University of Leeds
      Leeds, England, United Kingdom
  • 2008
    • Harrogate and District NHS Foundation Trust
      Harrogate, England, United Kingdom