C Zhang

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

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Publications (3)3.13 Total impact

  • S Shen · Y Zhao · W Yang · L Xu · Z Sun · X Chen · T Ji · C Zhang ·
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    ABSTRACT: In order to investigate the nerve distribution in mixed venous-lymphatic malformations (MVLMs), 57 postoperative patients diagnosed with MVLMs of the tongue were selected. Immunohistochemistry staining for neurofilament (NF) was used to detect sensory nerve fibers. Distribution of NF in samples from MVLMs was compared with distribution of NF in normal tongue tissue, venous malformations, lymphatic malformations and venular malformations. Results showed that the number of NF-positive nerve fibers in MVLMs was comparable to that in venous malformations and lymphatic malformations. The number of nerve fibers in MVLMs was significantly lower than in normal tissues. NF distribution in MVLMs was not affected by the patient's age or the coexistence of infection. These data suggest that the decreased distribution of sensory nerve fibers in MVLMs may be involved in the pathogenesis of MVLM of the tongue.
    International Journal of Oral and Maxillofacial Surgery 11/2008; 37(12):1106-10. DOI:10.1016/j.ijom.2008.09.003 · 1.57 Impact Factor
  • J D Wang · X C Deng · X J Jin · C Zhang · J Q Zhou · Q Y Zhou · J Liu · M F Qian ·
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    ABSTRACT: To study the technique of sentinel lymph node mapping in the papillary thyroid carcinoma and its evaluation in the search for cervical metastases. Exploration of the sentinel lymph nodes of the papillary thyroid carcinoma by injection of methylene blue around the tumour among 25 patients during surgery. The nodes which stained blue and the other nodes removed by functional neck dissection were examined histologically after staining with hematoxylin-eosin-saffron (HES). We have evaluated the predictive value of the technique in mapping the cervical metastases in the sentinel lymph node. Among the 25 patients, 22 patients presented sentinel lymph nodes (blue-stained), that is to say a rate of identification of 88%. At histological examination, 19 of the 22 patients had positive sentinel lymph nodes, of which 13 had also positive nodes not coloured with blue. The histological examination of patients without sentinel lymph node was negative. The technique of the sentinel lymph node has a strong positive predictive value in the search for cervical node metastases in the papillary thyroid carcinoma.
    Revue de laryngologie - otologie - rhinologie 02/2008; 129(4-5):285-7.
  • M Ruan · T Ji · Z Wu · J Zhou · C Zhang ·
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    ABSTRACT: Midkine, a new member of the heparin-binding growth factor family, was found recently to have a high expression level in many carcinoma specimens, including oesophagus, gall, bladder, pancreas, colorectum, breast and lung carcinomas, but few relevant studies have been performed. The aim of this study was to investigate the expression of midkine in oral squamous cell carcinoma (OSCC) and its correlation with tumour angiogenesis. Surgical specimens from 62 cases of OSCC and 10 cases of normal oral mucosa were examined by immunohistochemistry. The relationship between expression of midkine and the clinicopathological data and tumour angiogenesis was analysed. Midkine proteins were overexpressed in OSCC. The level of midkine expression was found to be significantly correlated with tumour size (P = 0.01), clinical stage (P = 0.002) and prognosis (P = 0.038). High midkine expression was associated with higher tumour angiogenesis as reflected by increased vascular endothelial growth factor expression (P = 0.005) and higher microvessel density (P = 0.004). These results indicate that midkine may be of great value in assessing the development and prognosis of OSCC, and could be taken as a new target for OSCC therapy.
    International Journal of Oral and Maxillofacial Surgery 03/2007; 36(2):159-64. DOI:10.1016/j.ijom.2006.09.004 · 1.57 Impact Factor

Publication Stats

35 Citations
3.13 Total Impact Points


  • 2007-2008
    • Shanghai Jiao Tong University
      • Department of Oral and Maxillofacial Surgery
      Shanghai, Shanghai Shi, China