Publications (2)2.17 Total impact
Article: Involvement of nuclear factor-kappaB in lipoteichoic acid-induced cyclooxygenase-2 expression in RAW 264.7 macrophages.[show abstract] [hide abstract]
ABSTRACT: We have investigated the role of protein kinase C (PKC) and nuclear factor-kappaB (NF-kappaB) in cyclooxygenase-2 (COX-2) expression caused by Staphylococcus aureus lipoteichoic acid in RAW 264.7 macrophages. A phosphatidylcholine-phospholipase C (PC-PLC) inhibitor (D-609) and a phosphatidylinositol-phospholipase C (PI-PLC) inhibitor (U-73122) attenuated lipoteichoic acid-induced COX-2 expression, while a phosphatidate phosphohydrolase inhibitor (propranolol) had no effect. Two PKC inhibitors (Go 6976 and Ro 31-8220) and the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), also attenuated lipoteichoic acid-induced COX-2 expression. Lipoteichoic acid resulted in a decrease in PKC activity in the cytosol and an increase in PKC activity in membranes. The lipoteichoic acid-induced translocation of p65 NF-kappaB from the cytosol to the nucleus was inhibited by D-609, U-73122, Go 6976, Ro 31-8220, and PDTC, but not by propranolol. The results suggested that lipoteichoic acid might have activated PC-PLC and PI-PLC to induce PKC activation, which in turn initiated NF-kappaB activation, and finally induced COX-2 expression in RAW 264.7 macrophages.Journal of Pharmacy and Pharmacology 02/2003; 55(1):115-23. · 2.17 Impact Factor
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ABSTRACT: Field emission display (FED) has been considered as one of the most promising application of carbon nanotubes. In FED application, the CVD assisted grown CNT cathodes have major problems, i.e., the screen effect of the well aligned CNT array reduces the field emission characteristics. The post treatments for cathode become necessary to improve the field emission characteristics and uniformity of the CNT emitters. In this study, well-aligned carbon nanotube array on Si substrate were synthesized by using a catalyst-assisted microwave plasma electron cyclotron resonance chemical vapor deposition (ECR-CVD) system with methane as source gas. Then a series of post treatment, including hydrogen plasma, oxygen plasma and electroless nickel plating, were conducted on the as grown CNT arrays. The results show that the H-plasma may damage the stems of CNTs at longer etching time. Consequently, the field emission characteristic of CNTs is reduced. In contrast, oxygen plasma increases the field emission characteristic of CNTs by reducing CNTs diameter and increasing inter-tube distance. Comparing to plasma post-treatment, electroless nickel-plating post-treatment is apparently improve the field emission characteristic of CNTs. This process results in the gathering of nickel catalysts at the top of CNTs and concentration CNTs field emission ability.Diamond and Related Materials. 15:854-858.