C. J. Van Leeuwen

Publications (1)0 Total impact

• Article: Residual effects on actual car driving of evening dosing of chlorpheniramine 8 and 12 mg when use with terfenadine 60 mg in the morning

  A. Vermeeren, J. G. Ramaekers, C. J. Van Leeuwen, J. F. O'Hanlon
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  ABSTRACT: The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Ss were 24 healthy female volunteers (aged 22-45 yrs). Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests. (PsycINFO Database Record (c) 2006 APA, all rights reserved) DOI: doi:10.1002/(SICI)1099-1077(1998110)13:2+ 3.3.CO;2-3
  01/1998;