C G Stief

Publications (3)3.65 Total impact

• Article: CT-Urographie bei Frauen mit primären oder rezidivierenden Beckentumoren

  S. Seifert, U.G. Mueller-Lisse, C. Degenhart, K. Jundt, F. Mourched, C.G. Stief, M.F. Reiser, U.L. Mueller-Lisse
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  ABSTRACT: Maligne Beckentumoren stellen 12–13% aller neu diagnostizierten soliden Neoplasien bei Frauen in den USA und in Deutschland dar. Deutsche Leitlinien befürworten bildgebende Untersuchungen bei Lokalrezidiven und Metastasen; für Primärtumoren gibt es keine einschlägigen Empfehlungen. Da das Ausscheidungsurogramm durch die Ausscheidungsaufnahme der CT-Urographie (CTU) weitgehend abgelöst ist, wurde bei weiblichen Beckentumoren oder deren Rezidive der Zusammenhang zwischen CTU-Befunden und nachfolgenden operativen urologischen Maßnahmen retrospektiv von 2 unabhängigen Auswertern geprüft. Bei 31 CTUs von 27 Frauen (Alter 29–84, Median 57Jahre) mit 15 Primärtumoren und 13 Rezidiven waren 83–100% der unauffälligen oberen, mittleren und unteren Harnleitersegmente in der Ausscheidungsaufnahme (Delay 16min, Streubreite 6–29) vollständig abgrenzbar. Häufige pathologische Veränderungen waren Obstruktionen der unteren Harnleiter (19-mal, 61%), Harnblasenkompressionen (13-mal, 42%) und Harnblaseninvasionen (8-mal, 26%). Acht von 20 pathologisch veränderten, jedoch keiner von 10 unauffälligen Harnwegen wurden nachfolgend urologisch operativ versorgt (zweiseitiger Fisher-Exact-Test, p=0,0215). Daher scheint die CTU eine sinnvolle diagnostische Maßnahme vor der Weiterbehandlung weiblicher Beckentumoren oder deren Rezidive darzustellen. Malignant tumors of the female pelvis account for 12–13% of newly diagnosed solid neoplasms among women in the USA and Germany. German guidelines advocate diagnostic imaging for local recurrence and metastasis while there are no recommendations for primary tumors. As excretory urography has been replaced by the excretory phase of computed tomography urography (CTU) in many institutions, two independent observers retrospectively evaluated CTUs of primary or recurrent female pelvic tumors to rule out associations between CTU findings and subsequent urologic measures. Among 31 CTUs of 27 women (age 29–84 years, mean 57 years) with 15 primary and 13 recurrent tumors, 83–100% of unremarkable proximal, middle and distal ureter segments were completely delineated in the excretory phase (delay 6–29min, mean 16min). The most common pathological findings included distal ureter obstruction (n=19, 61%), bladder compression (n=13, 42%) and bladder invasion (n=8, 26%). Out of 20 pathologically altered urinary tracts 8 were subsequently subjected to urologic measures (2-tailed Fisher exact test, p=0.0215) but none of the 10 unremarkable urinary tracts were treated. It appears that CTU is a sensible pre-therapeutic test for the urinary tract for primary and recurrent female pelvic tumors. SchlüsselwörterBeckentumor–Zervixkarzinom–Ovarialkarzinom–Rezidiv–CT-Urographie (CTU) KeywordsPelvic tumour–Cervical cancer–Ovarian cancer–Recurrence–Computed tomography urography (CTU)
  Der Radiologe 04/2012; 51(7):602-609. · 0.61 Impact Factor
• Article: [CT urography in women with primary or recurrent pelvic tumors : background and initial experiences].

  S Seifert, U G Mueller-Lisse, C Degenhart, K Jundt, F Mourched, C G Stief, M F Reiser, U L Mueller-Lisse
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  ABSTRACT: Malignant tumors of the female pelvis account for 12-13% of newly diagnosed solid neoplasms among women in the USA and Germany. German guidelines advocate diagnostic imaging for local recurrence and metastasis while there are no recommendations for primary tumors. As excretory urography has been replaced by the excretory phase of computed tomography urography (CTU) in many institutions, two independent observers retrospectively evaluated CTUs of primary or recurrent female pelvic tumors to rule out associations between CTU findings and subsequent urologic measures. Among 31 CTUs of 27 women (age 29-84 years, mean 57 years) with 15 primary and 13 recurrent tumors, 83-100% of unremarkable proximal, middle and distal ureter segments were completely delineated in the excretory phase (delay 6-29 min, mean 16 min). The most common pathological findings included distal ureter obstruction (n=19, 61%), bladder compression (n=13, 42%) and bladder invasion (n=8, 26%). Out of 20 pathologically altered urinary tracts 8 were subsequently subjected to urologic measures (2-tailed Fisher exact test, p=0.0215) but none of the 10 unremarkable urinary tracts were treated. It appears that CTU is a sensible pre-therapeutic test for the urinary tract for primary and recurrent female pelvic tumors.
  Der Radiologe 06/2011; 51(7):602-9. · 0.61 Impact Factor
• Article: Catheter-based intraluminal optical coherence tomography versus endoluminal ultrasonography of porcine ureter ex vivo.

  U L Mueller-Lisse, O A Meissner, M Bauer, C Weber, G Babaryka, C G Stief, M F Reiser, U G Mueller-Lisse
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  ABSTRACT: To compare the distinction of tissue layers of porcine ureters ex vivo between optical coherence tomography (OCT) and endoluminal ultrasonography (ELUS). Catheter-guided OCT is a new method of intraluminal microstructural imaging, with a spatial resolution of 10-20 mum. Porcine ureters and kidneys were obtained fresh from the municipal slaughtery, cannulated with a 7F catheter sheath, flushed with normal saline solution, and marked on the outside with surgical suture. Between the marked positions, images were obtained from within the ureter lumen using OCT (M1, Lightlab, Westport, MA) and ELUS at 40 MHz. The distinction of the urothelium, lamina propria, and inner and outer muscle layers was rated as possible (1) or impossible (0) by 2 independent observers (O1, O2). The rates of distinction were compared between OCT and ELUS image quadrants using the chi(2) test. Of the 224 OCT image quadrants and 144 ELUS image quadrants, OCT was superior to ELUS in the distinction of any wall layers (O1, chi(2)P = 68.1051, P < .001; O2, chi(2)P = 66.1630, P < .001), urothelium and lamina propria (O1, chi(2)P = 200.0750, P < .001; O2, chi(2)P = 240.0024, P < .001), and lamina propria and muscle layer (O1, chi(2)P = 38.8411, P < .001; O2, chi(2)P = 24.7536, P < .001) but was inconclusive for the inner and outer muscle layer (O1, chi(2)P = 260.3004, P < .001; O2, chi(2)P = 0.4992, P > .25). OCT was able to distinguish significantly better than ELUS between different wall layers of porcine ureter ex vivo. The feasibility of OCT in vivo and in the presence of pathologic wall thickening of the ureter remains to be demonstrated.
  Urology 04/2009; 73(6):1388-91. · 2.43 Impact Factor