Bo Zhou

Publications (24)85.31 Total impact

• Article: [Measurement of 16 elements in blood by inductively coupled plasma mass spectrometry].

  Hui-Ling Li, Feng-Tong Hao, Jing Ma, Bo Zhou
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  ABSTRACT: To establisha method of determining more elements in whole blood by inductively coupled plasmamass spectrometry (ICP-MS). Thewhole blood sampleswere treated by 5% nitric acid to remove the proteins, then were centrifuged. Sixteen elements (Be, Al, Mn, V, Cr, Co, Ni, As, Mo, Ag, Cd, Sb, Ba,Tl, Pb and U) in the supernatant were directly measured by ICP-MS. The detection limits of 16 elements were 0.01 ∼ 6.51 µg/L. The linear correlation coefficientr was ≥ 0.999. The relative standard deviations were below 5 %. The recovery rates were 105% ∼ 115%. Seronorm Trace Elements SerumL-1 LOT 0903106 and GBW09139g or GBW09140g were used in the quality control, the detected results corresponded with the standard values. ICP-MS technique is a simple, rapid, accurate and reliable method, which can be used to measure several trace elements in whole blood samples.
  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 07/2012; 30(7):540-2.
• Article: Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies.

  Ze-Mu Wang, Zhen-Lin Nie, Bo Zhou, Xiao-Qing Lian, Huan Zhao, Wei Gao, Yong-Sheng Wang, En-Zhi Jia, Lian-Sheng Wang, Zhi-Jian Yang
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  ABSTRACT: Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies. We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model. A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95% CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20mg/day, summary RR: 0.96; 95% CI: 0.90, 1.03). Our results do not support a protective role of flavonols intake against CHD.
  Atherosclerosis 02/2012; 222(1):270-3. · 3.79 Impact Factor
• Article: C-reactive protein, interleukin 6 and lung cancer risk: a meta-analysis.

  Bo Zhou, Jing Liu, Ze-Mu Wang, Tao Xi
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  ABSTRACT: Epidemiologic findings are inconsistent concerning the associations between C-reactive protein (CRP), interleukin 6 (IL-6) and lung cancer risk. We conducted a meta-analysis of epidemiologic studies to examine these associations. A systematic literature search up to October 2011 was performed in MEDLINE and EMBASE. Study-specific risk estimates were pooled using a random-effects model. The 10 studies on CRP involved a total of 1918 lung cancer cases. The pooled RR of lung cancer for one unit change in natural logarithm (ln) CRP was 1.28 (95% CI 1.17-1.41). There was no statistically significant heterogeneity among studies (P = 0.116; I(2) = 36.6%). We also found that CRP was significantly associated with increased risk of lung cancer among men (RR 1.18, 95% CI 1.09-1.28) but not among women. The 5 studies on IL-6 involved a total of 924 lung cancer cases. The pooled RR of lung cancer for one unit change in ln IL-6 was 1.28 (95% CI 0.92-1.79), however, statistically significant heterogeneity was found. After excluding the study contributing most to the heterogeneity, the summary estimate was essentially unchanged. CRP was associated with increased risk of lung cancer, especially among men. There was no significant association between IL-6 and lung cancer risk.
  PLoS ONE 01/2012; 7(8):e43075. · 4.09 Impact Factor
• Article: Black and green tea consumption and the risk of coronary artery disease: a meta-analysis.

  Ze-Mu Wang, Bo Zhou, Yong-Sheng Wang, Qing-Yue Gong, Qi-Ming Wang, Jian-Jun Yan, Wei Gao, Lian-Sheng Wang
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  ABSTRACT: Epidemiologic studies are inconsistent regarding the association between tea consumption and the risk of coronary artery disease (CAD). The objective was to perform a meta-analysis to determine whether an association exists between tea consumption and total CAD endpoints in observational studies. We searched PUBMED and EMBASE databases for studies conducted from 1966 through November 2009. Study-specific risk estimates were combined by using a random-effects model. A total of 18 studies were included in the meta-analysis: 13 studies on black tea and 5 studies on green tea. For black tea, no significant association was found through the meta-analysis [highest compared with lowest, summary relative risk (RR): 0.92; 95% CI: 0.82, 1.04; an increment of 1 cup/d, summary RR: 0.98; 95% CI: 0.94, 1.02]. For green tea, the summary RR indicated a significant association between the highest green tea consumption and reduced risk of CAD (summary RR: 0.72; 95% CI: 0.58, 0.89). Furthermore, an increase in green tea consumption of 1 cup/d was associated with a 10% decrease in the risk of developing CAD (summary RR: 0.90; 95% CI: 0.82, 0.99). Our data do not support a protective role of black tea against CAD. The limited data available on green tea support a tentative association of green tea consumption with a reduced risk of CAD. However, additional studies are needed to make a convincing case for this association.
  American Journal of Clinical Nutrition 03/2011; 93(3):506-15. · 6.67 Impact Factor
• Source

  Available from: Qingmin Sun

  Article: Alcohol consumption and the risk of endometrial cancer: a meta-analysis.

  Qingmin Sun, Linlin Xu, Bo Zhou, You Wang, Yali Jing, Bin Wang
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  ABSTRACT: Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with alcohol consumption. Therefore, we conduct a meta-analysis of studies that assessed the association of alcohol consumption and the risk of endometrial cancer. A systematic literature search up to April 2010 was performed in MEDLINE and EMBASE, and study-specific risk estimates were pooled using a random-effects model. In the present study, six prospective and 14 case-control studies were included. Alcohol intake was not significantly associated with the risk of endometrial cancer among prospective studies (relative risk (RR): 1.04; 95% confidence interval (CI): 0.91-1.18) or among case-control studies (odds ratio (OR): 0.89; 95% CI: 0.76-1.05). However evidence from the results of our stratified analyses revealed that increased risk of endometrial cancer was associated with liquor consumption (RR: 1.22; 95% CI: 1.03-1.45) but null association with wine and beer consumption. In conclusion, alcohol consumption is not associated with the risk of endometrial cancer. Future studies should also examine whether the relation varies according to different type of alcoholic beverages.
  Asia Pacific Journal of Clinical Nutrition 01/2011; 20(1):125-33. · 1.13 Impact Factor
• Article: Flavonoids intake and risk of lung cancer: a meta-analysis.

  Na-Ping Tang, Bo Zhou, Bin Wang, Rong-Bin Yu, Jing Ma
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  ABSTRACT: A number of studies have evaluated the association between flavonoids intake and lung cancer risk. However, results were inconsistent. To clarify the role of flavonoids in lung cancer, we conducted a meta-analysis on this topic. Two authors independently searched PubMed and EMBASE for studies regarding the association of flavonoids intake with lung cancer risk. Summary relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated by using random-effects model. Eight prospective studies and four case-control studies involving 5073 lung cancer cases and 237 981 non-cases were included in this meta-analysis. The combined results indicated a statistically significant association between highest flavonoids intake and reduced risk of developing lung cancer (RR = 0.76, 95% CI = 0.63-0.92). Furthermore, an increase in flavonoids intake of 20 mg/day was associated with a 10% decreased risk of developing lung cancer (RR = 0.90, 95% CI = 0.83-0.97). In stratified analyses, the highest flavonoids intake was significantly associated with decreased lung cancer risk in prospective studies, studies conducted in Finnish population, studies without adjustment for fruits and vegetables or vitamins, males, smokers and studies using dietary history interview for flavonoids intake estimation. Most subclasses of flavonoids were inversely associated with lung cancer except for hesperetin. Our data indicate that high or an increased intake of flavonoids is associated with reduced risk of lung cancer in some population but not in other population.
  Japanese Journal of Clinical Oncology 05/2009; 39(6):352-9. · 1.78 Impact Factor
• Article: HTRA1 promoter polymorphism and risk of age-related macular degeneration: a meta-analysis.

  Na-Ping Tang, Bo Zhou, Bin Wang, Rong-Bin Yu
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  ABSTRACT: To clarify the role of human high-temperature requirement A-1 (HTRA1) gene promoter polymorphism (-512G>A) in age-related macular degeneration (AMD). Relevant studies were identified by searching PubMed and EMBASE database. A logistic regression analysis proposed for molecular association studies was carried out to estimate the genetic effect and the possible genetic model of action. Fourteen case-control studies were included in this meta-analysis. There was strong evidence for an association between HTRA1 -512G>A polymorphism and AMD (p < 0.001). The genetic model test indicated that the genetic model was most likely to be co-dominant. Overall, our meta-analysis showed that AA and GA genotypes were associated with increased risk of AMD (AA vs. GG: odds ratio(1) [OR(1)] = 7.46; 95% confidence interval [CI] = 6.16-9.04; GA vs. GG: OR(2) = 2.27, 95% CI = 2.02-2.55). In stratified analysis by ethnicity and age, the genetic effect seemed to be stronger in Caucasians and subjects > or =73 years of age than in Asians and subjects <73 years of age. When subgroup analysis was conducted by AMD type, significant association was noted for wet AMD but not for dry AMD. This meta-analysis summarizes the strong evidence for an association between HTRA1 -512G>A polymorphism and AMD and indicates a co-dominant model of action.
  Annals of epidemiology 04/2009; 19(10):740-5. · 2.95 Impact Factor
• Article: Green tea, black tea consumption and risk of lung cancer: a meta-analysis.

  Naping Tang, Yuemin Wu, Bo Zhou, Bin Wang, Rongbin Yu
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  ABSTRACT: Studies investigating the association of green tea and black tea consumption with lung cancer risk have reported inconsistent findings. To provide a quantitative assessment of this association, we conducted a meta-analysis on the topic. Studies were identified by a literature search in PubMed from 1966 to November 2008 and by searching the reference lists of relevant studies. Summary relative risk (RR) estimates and their corresponding 95% confidence intervals (CIs) were calculated based on random-effects model. Our meta-analysis included 22 studies provided data on consumption of green tea or black tea, or both related to lung cancer risk. For green tea, the summary RR indicated a borderline significant association between highest green tea consumption and reduced risk of lung cancer (RR=0.78, 95% CI=0.61-1.00). Furthermore, an increase in green tea consumption of two cups/day was associated with an 18% decreased risk of developing lung cancer (RR=0.82, 95% CI=0.71-0.96). For black tea, no statistically significant association was observe through the meta-analysis (highest versus non/lowest, RR=0.86, 95% CI=0.70-1.05; an increment of two cups/day, RR=0.82, 95% CI=0.65-1.03). In conclusion, our data suggest that high or an increase in consumption of green tea but not black tea may be related to the reduction of lung cancer risk.
  Lung cancer (Amsterdam, Netherlands) 02/2009; 65(3):274-83. · 3.14 Impact Factor
• Source

  Available from: reseau-naissance.com

  Article: Coffee consumption and risk of breast cancer: a metaanalysis.

  Naping Tang, Bo Zhou, Bin Wang, Rongbin Yu
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  ABSTRACT: This metaanalysis was conducted to assess the association between coffee consumption and breast cancer risk. Relevant studies were identified by searching Medline (1966-May 2008) and the reference lists of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated using a random-effects model. Nine cohort and 9 case-control studies met the inclusion criteria. The combined RR showed a borderline significant influence of highest coffee consumption (RR, 0.95; 95% CI, 0.90-1.00) or an increment of 2 cups/day of coffee consumption (RR, 0.98; 95% CI, 0.96-1.00) on the risk of breast cancer. In stratified analysis, borderline significant associations were observed among cohort and case-control studies and studies conducted in Europe and the United States. However, no significant association was noted among studies conducted in Asia. Our findings suggest a possible influence of high coffee consumption or an increased coffee consumption on the risk of breast cancer.
  American journal of obstetrics and gynecology 01/2009; 200(3):290.e1-9. · 3.28 Impact Factor
• Article: The association between the survivin C-31G polymorphism and gastric cancer risk in a Chinese population.

  Li Yang, Huaijun Zhu, Bo Zhou, Haijuan Gu, Hongli Yan, Naping Tang, Hanzhang Dong, Qingmin Sun, Rihong Cong, Guoyu Chen, Bin Wang
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  ABSTRACT: The C-31G polymorphism in the survivin promoter could de-repress the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect of the polymorphism on other cancers, including gastric cancer. In this hospital-based, case-control study, we investigated the association between the survivin C-31G polymorphism and risk of gastric cancer in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocols. No statistically significant association was observed between gastric cancer risk and the variant genotype (GG + GC). However, the variant genotype (GG + GC) was either associated with risk of distal gastric cancer (odds ratios=0.50, 95% confidence interval=0.30-0.83) or with risk of well-differentiated tumor (odds ratios=0.46, 95% confidence interval=0.22-0.97). Our results demonstrate that the survivin C-31G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in a Chinese population.
  Digestive Diseases and Sciences 09/2008; 54(5):1021-8. · 2.12 Impact Factor
• Article: Smoking and the risk of age-related macular degeneration: a meta-analysis.

  Rihong Cong, Bo Zhou, Qingmin Sun, Haijuan Gu, Naping Tang, Bin Wang
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  ABSTRACT: Some studies were undertaken to evaluate the association between cigarette smoking and age-related macular degeneration (AMD). This meta-analysis summarized the risk estimate of smoking and AMD and provided robust evidence for the association. Relevant studies were identified by searching PubMed and MEDLINE (from 1966 to June 2007) and reviewing the reference lists of key articles. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated. Study-specific risk estimates were pooled using a random-effects model. Five prospective cohort and eight case-control studies met our inclusion criteria. Ever smoking was statistically significant associated with increased risk of AMD among cohort studies (RR, 1.61; 95% CI, 1.01-2.57) or case-control studies (RR, 1.76; 95% CI, 1.56-1.99). Current smokers were at higher risk of AMD than past smokers. Both geographic atrophy (GA) and neovascular AMD (NV) are subtypes of AMD. A significant relationship was found between smoking and GA risk. Smoking increased the risk of NV, with marginal nonsignificance (RR, 1.47; 95% CI, 0.92-2.37) in cohort studies and significance in case-control studies (RR, 1.96; 95% CI, 1.69-2.27). This meta-analysis indicated smoking, especially current smoking, was significantly associated with increased risks of AMD and its subtypes.
  Annals of epidemiology 08/2008; 18(8):647-56. · 2.95 Impact Factor
• Article: Cigarette smoking and the risk of endometrial cancer: a meta-analysis.

  Bo Zhou, Li Yang, Qingmin Sun, Rihong Cong, Haijuan Gu, Naping Tang, Huaijun Zhu, Bin Wang
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  ABSTRACT: Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with cigarette smoking. We conducted a meta-analysis of epidemiologic studies to examine this relation. A systematic literature search up to June of 2007 was performed in MEDLINE and EMBASE. Study-specific risk estimates were pooled using a random-effects model. Ten prospective and 24 case-control studies were included in the analysis of the effect of ever smoking. Ever smoking was statistically significantly associated with a reduced risk of endometrial cancer among prospective studies (relative risk 0.81; 95% confidence interval [CI], 0.74-0.88) and case-control studies (odds ratio 0.72; 95% CI, 0.66-0.79). The inverse association was significant among current and former smokers. Six prospective and 6 case-control studies were included in the quantitative analysis. We noted that an increase in smoking of 20 cigarettes per day was statistically significantly associated with 16% and 27% reduced risks of endometrial cancer in prospective and case-control studies, respectively. We also found that cigarette smoking was significantly associated with a decreased risk of endometrial cancer among postmenopausal women (relative risk 0.71; 95% CI, 0.65-0.78) but not among premenopausal women. In addition, the risk reduction seemed to be stronger among hormone replacement therapy users than nonusers. Cigarette smoking was found to be significantly associated with a reduced risk of endometrial cancer, especially among postmenopausal women.
  The American journal of medicine 07/2008; 121(6):501-508.e3. · 4.47 Impact Factor
• Article: Association of endothelin-converting enzyme-1b C-338A polymorphism with gastric cancer risk: a case-control study.

  Haijuan Gu, Li Yang, Naping Tang, Bo Zhou, Huaijun Zhu, Qingmin Sun, Rihong Cong, Bin Wang
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  ABSTRACT: To investigate the association between endothelin-converting enzyme-1b (ECE-1b) C-338A polymorphism and gastric cancer risk, we conducted a hospital-based case-control study of 256 gastric cancer cases and 256 controls matched on age and gender. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. We found that the genotype frequencies were significantly different (P=0.005) between cases and controls. Compared with the wild genotype CC, the variant genotypes (CA+AA) were associated with a 64% increased risk of gastric cancer [adjusted odds ratio (OR)=1.64, 95% confidence interval (CI) 1.15-2.33]. Further stratification analyses indicated that the increased risk was especially noteworthy in older subjects (age 58) (adjusted OR=1.91, 95% CI 1.18-3.09), women (adjusted OR=2.30, 95% CI 1.11-4.79) and non-smokers (adjusted OR=1.79, 95% CI 1.19-2.67). Our results suggest that the ECE-1b C-338A polymorphism may be associated with increased risk of gastric cancer.
  European Journal of Cancer 07/2008; 44(9):1253-8. · 5.54 Impact Factor
• Article: Gly82Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population.

  Haijuan Gu, Li Yang, Qingmin Sun, Bo Zhou, Naping Tang, Rihong Cong, Ying Zeng, Bin Wang
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  ABSTRACT: It has been shown that the expression of the receptor for advanced glycation end products (RAGE) is closely associated with invasion and metastasis in gastric cancer. A Gly82Ser polymorphism in exon 3 of RAGE gene was identified and thought to have an effect on the functions of its protein. Therefore, the goal of the present study was to investigate whether the polymorphism is involved in the development or progression of gastric cancer. In the hospital-based case-control study, the RAGE genotypes were determined using PCR-RFLP in 566 individuals (283 gastric cancer patients and 283 age- and sex-matched controls). The distribution of genotype was significantly different between cases and controls (P = 0.038). Compared with the wild-type 82Gly/Gly carriers, subjects with the variant genotypes (82Gly/Ser and 82Ser/Ser) had a significantly higher risk of gastric cancer (adjusted odds ratio, 1.47; 95% confidence interval, 1.05-2.06). Moreover, the elevated gastric cancer risk was especially evident in younger individuals (ages < or =58 years), nonsmokers, and rural subjects. Further analyses revealed that the variant genotypes were associated with adjacent organ invasion in the subanalysis of gastric cancer patients. Our findings indicate that the RAGE Gly82Ser polymorphism may confer not only an increased risk of gastric cancer but also with invasion of gastric cancer in the Chinese population.
  Clinical Cancer Research 06/2008; 14(11):3627-32. · 7.74 Impact Factor
• Article: Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population.

  Na-Ping Tang, Lian-Sheng Wang, Li Yang, Hai-Juan Gu, Qing-Min Sun, Ri-Hong Cong, Bo Zhou, Huai-Jun Zhu, Bin Wang
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  ABSTRACT: Glutathione peroxidase 1 (GPX1), the key antioxidant enzyme in vascular endothelial cells, has been shown to exert a protective effect against the presence of coronary artery disease (CAD). The 198Pro/leu variant, located at codon 198 of GPX1 gene, has recently been linked to cardiovascular disease, but data were inconsistent. We investigated the association between the occurrence of CAD and the 198Pro/leu variant in a Chinese population. A total of 265 unrelated CAD patients and 265 age- and sex-matched control subjects were recruited in this study. The GPX1 198Pro/leu genotype was determined using polymerase chain reaction-restriction fragment length polymorphism. Compared to the 198Pro/Pro carriers, subjects with the variant genotypes (198Pro/leu and 198Leu/leu) had a significantly higher risk of CAD (adjusted OR=2.02, 95%CI=1.27-3.22). In stratified analyses, the variant genotypes were significantly associated with increased CAD risk in subjects <64 y (adjusted OR=2.41, 95%CI=1.16-4.98), males (adjusted OR=1.86, 95%CI=1.09-3.18) and non-smokers (adjusted OR=2.40, 95%CI=1.15-5.01). However, no significant association was observed between this variant and the severity of CAD. These data provide evidence that GPX1 198Pro/leu variant genotypes are significantly associated with CAD risk in this Chinese population.
  Clinica Chimica Acta 05/2008; 395(1-2):89-93. · 2.54 Impact Factor
• Article: Hormone replacement therapy and ovarian cancer risk: a meta-analysis.

  Bo Zhou, Qingmin Sun, Rihong Cong, Haijuan Gu, Naping Tang, Li Yang, Bin Wang
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  ABSTRACT: Epidemiologic findings are inconsistent concerning the risk for ovarian cancer associated with hormone replacement therapy (HRT). We conducted a meta-analysis to summarize the available evidence from observational studies to examine this relation. We searched PUBMED and MEDLINE for relevant studies that were published from January 1, 1966, through May 1, 2007. Study-specific risk estimates were pooled by the use of a random-effects model. Eight cohort (including 4715 cases and 1,555,374 participants) and 19 case-control studies (involving 8240 cases and 20,996 controls) were included. We found a summary relative risk (RR) of 1.24 (95% confidence interval [CI] 1.15-1.34) from cohort studies and a summary odds ratio [OR] of 1.19 (95%CI 1.02-1.40) from case-control studies for ever HRT use. However, the risk estimates of case-control studies might be upwardly biased. Summary risk estimates of four cohort and six case-control studies that distinguished estrogen replacement treatment (ERT) and estrogen-progestin replacement treatment (EPRT) from HRT both indicated that association was stronger among ERT user than EPRT user. Based on data abstracted from six case-control studies, duration of HRT use was not significant. The summary risk estimates for less than 5 years, 6-10, and more than 10 years use were 1.02, 1.13, and 1.21, respectively and 95%CI for each estimate crossed 1.0. HRT use was associated with increased risk of ovarian cancer. These findings may expand the range of possible risks associated with HRT use. However, this positive association should also be considered in the context of HRT's other favorable effects on health.
  Gynecologic Oncology 04/2008; 108(3):641-51. · 3.89 Impact Factor
• Article: Preproghrelin Leu72Met polymorphism in Chinese subjects with coronary artery disease and controls.

  Na-Ping Tang, Lian-Sheng Wang, Li Yang, Hai-Juan Gu, Huai-Jun Zhu, Bo Zhou, Qing-Min Sun, Ri-Hong Cong, Bin Wang
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  ABSTRACT: Ghrelin, a novel endogenous ligand for the growth hormone secretagogue receptor, is considered to exert a protective effect against atherosclerosis. The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome. However, it is unclear whether this polymorphism is associated with coronary artery disease (CAD). We conducted a case-control study with 317 CAD patients and 323 controls to investigate the potential association of the Leu72Met polymorphism with the occurrence of CAD and CAD-related phenotypes in Chinese population. No significant difference in the Leu72Met genotype frequency was observed between CAD patients and controls (P=NS). The Leu72Met polymorphism was not associated with hypertension, diabetes, dyslipidemia, the number of diseased vessels, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol or fasting glucose levels in CAD patients. However, among CAD patients, those with variant genotypes (Leu72Met and Met72Met) had lower BMI (24.4+/-0.3 kg/m(2)) than Leu72Leu carriers (25.4+/-0.2 kg/m(2), adjusted P=0.033). Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with CAD in Chinese population. However, the Leu72Met variant is associated with BMI among CAD patients.
  Clinica Chimica Acta 02/2008; 387(1-2):42-7. · 2.54 Impact Factor
• Article: Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population.

  Na-Ping Tang, Lian-Sheng Wang, Li Yang, Bo Zhou, Hai-Juan Gu, Qing-Min Sun, Ri-Hong Cong, Huai-Jun Zhu, Bin Wang
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  ABSTRACT: The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population. The study population consisted of 265 CAD patients and 265 age- and sex-matched control subjects. The T allele frequency was significantly lower among CAD patients than among control subjects (18.3% vs. 29.8%; P < 0.001). In both the CAD and control groups, the T allele carriers had higher high density lipoprotein cholesterol (HDL-C) levels than homozygote C allele carriers. In a multiple logistic regression model adjusted for age, sex, body mass index, smoking, hypertension, diabetes, hyperlipidemia, and low density lipoprotein cholesterol, a significantly decreased risk of developing CAD was found in subjects carrying a variant CT or TT genotype (odds ratio = 0.496, 95% confidence interval = 0.341-0.723; P < 0.001), and the significance persisted after further adjustment for HDL-C. In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.
  The Journal of Lipid Research 02/2008; 49(2):369-75. · 5.56 Impact Factor
• Article: A polymorphism in the resistin gene promoter and the risk of coronary artery disease in a Chinese population.

  Na-Ping Tang, Lian-Sheng Wang, Li Yang, Bo Zhou, Hai-Juan Gu, Qing-Min Sun, Ri-Hong Cong, Huai-Jun Zhu, Bin Wang
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  ABSTRACT: Resistin, a novel adipocyte-derived peptide, has been linked to the pathogenesis of atherosclerosis. Recently, -420C>G, a variant located in the promoter region of the resistin gene (RETN) was identified. The aim of this study was to investigate the association between this RETN-420C>G polymorphism and the risk of coronary artery disease (CAD). A hospital-based case-control study. A total of 225 CAD patients and 225 age- and sex-matched control subjects. Genotyping was performed by polymerase chain reaction (PCR) and restriction enzyme analysis to detect the presence of the RETN-420C>G polymorphism. The frequencies of RETN-420C>G genotypes in the CAD group were significantly different from those in the control group (P = 0.024). Subjects with the variant genotypes (CG and GG) had a 62% increased risk of CAD compared to CC carriers [adjusted odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.09-2.41, P = 0.016]. However, there were no significant differences between the genotypes with respect to weight, body mass index (BMI) and lipid profiles in CAD patients, and no significant association was found between the RETN-420C>G polymorphism and the severity of CAD. Our data suggest that the RETN-420C>G polymorphism might be associated with an increased risk of CAD in a Chinese population.
  Clinical Endocrinology 01/2008; 68(1):82-7. · 3.17 Impact Factor
• Article: The association of tea consumption with ovarian cancer risk: A metaanalysis.

  Bo Zhou, Li Yang, Liansheng Wang, Yanping Shi, Huaijun Zhu, Naping Tang, Bin Wang
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  ABSTRACT: This metaanalysis was undertaken to evaluate the relationship between tea intake and ovarian cancer risk. A systematic literature search up to September 2006 was performed in Medline, Embase, CANCERLIT, and the Cochrane Database. The summary relative risk was calculated. A sensitivity analysis was conducted to test the influence of each single study. Heterogeneity and publication bias were also evaluated. Two cohort and 7 case-control studies were included. The combined relative risk did not show that tea consumption was associated with a reduced ovarian cancer risk (relative risk, 0.84; 95% confidence interval, 0.66-1.07). When the analyses were stratified into subgroups, there was no evidence that study design substantially influenced the estimate of effects. The sensitivity analysis which means removing one study at a time confirmed the stability of our results. Our findings did not support that tea consumption was related to the decreased risk of ovarian cancer.
  American journal of obstetrics and gynecology 01/2008; 197(6):594.e1-6. · 3.28 Impact Factor