A Héraud

Clinique Pasteur, Toulouse, Tolosa de Llenguadoc, Midi-Pyrénées, France

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Publications (4)0 Total impact

  • Revue du Rhumatisme 02/1994; 61(1):59-60.
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    ABSTRACT: Two cases of myeloma with roentgenographic evidence of bone sclerosis confirmed by iliac histomorphometric measurements are reported. In one patient, increased resorption, major depression of osteoblast activity, initial intense myelofibrosis, and myeloid deposits were found. The other patient had both increased resorption and increased osteoblast activity with clinical manifestations suggestive of POEMS syndrome. These two cases are compared with 116 cases previously published in the occidental medical literature and with five histomorphometric studies demonstrating increased bone trabecula volume (BTV). Conventional histologic studies suggest several mechanisms as possible explanations for the occurrence of bone sclerosis, including increased modeling unit activity, isolated osteoblast activation, metamorphic neoosteogenesis in myelofibrosis foci, and, in exceptional cases, inhibition of resorption due to increased production of calcitonin. The diversity of bone modeling patterns evidenced by the seven histomorphometric studies reviewed in this article is striking. Bone modeling patterns provide only a snapshot of bone modeling units and may vary over time in a given patient. Reported cases are too few to allow conclusions but emphasize the need for performing further histomorphometric investigations.
    Revue du rhumatisme et des maladies ostéo-articulaires 07/1992; 59(6):449-54.
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    ABSTRACT: Study of the HLA-B grouping of 193 patients with psoriatic arthropathy (PA), compared with that of a control series consisting of 2,706 healthy subjects representative of the French population, revealed a statistically significant link between PA and antigens B27, B17 and B16. In contrast to reported findings of earlier studies, the authors found no link between an HLA-B antigen and any particular topographical or anatomical form of PA. Antigen B27 was not statistically significantly linked with axial forms of PA nor did it protect against peripheral forms. There were neither more cases of peripheral involvement nor less of axial involvement among non-B27 PA patients. The only statistically significant link which could be shown was that between antigen B27 and sacroiliac involvement in recent PA, present for less than 10 years. The authors conclude that in 60 per cent of cases, PA is associated with a particular antigen: B16, B17 or B27. Involvement of the sacroiliac joints is more common in cases of B27 PA and above all occurs earlier than in others. Regardless of its HLA group, PA as it progresses shows an increasingly clear mixture of spinal, peripheral and sacroiliac lesions, which forms the basis of the originality of this condition.
    Revue du rhumatisme et des maladies ostéo-articulaires 05/1991; 58(4):269-73.
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    ABSTRACT: After a reminder of the major points of the pharmacokinetics of non-steroid anti-inflammatory drugs, the authors report the results of a multicentric study of the kinetics of naproxen after oral intake of one single dose of 1 gram in patients with rheumatoid arthritis. The half-life is longer in the synovial fluid than in the serum, 23 hours versus 17 hours. The balance point is obtained at the 24th hour and, at that time, the naproxen level in the synovium and the joint fluid are 32 and 60 p. cent, respectively, of the corresponding maximum concentrations.
    Revue du rhumatisme et des maladies ostéo-articulaires 05/1988; 55(6):435-9.