Publications (1)0 Total impact
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Jamilé Hazan,
Bertrand Fontaine,
Richard P.M. Bruyn,
Catherine Lamy,
Judith C.T. van Deutekom,
Clalre-Sophie Rime,
Alexandra Dürr,
Judith Melkl,
Olivier Lyon-Caen,
Yves Agid, Arnold Munnich,
George W Padberg,
Jean de Recondo,
Rune R Frants,
Alexis Brice,
Jean Welssenbach
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ABSTRACT: Autosomal dominant familial spastic paraplegia (ADFSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21 – p24 In five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.
