Alp Aslan

Istanbul University, İstanbul, Istanbul, Turkey

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Publications (4)6.01 Total impact

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    ABSTRACT: Neoplasia and hyperplasia of the temporomandibular joint-related connective tissue are among the rare causes of disc displacement and temporomandibular joint (TMJ) dysfunction. Here we present an unusual case of hyperplasia of the glenoid fossa, treated for TMJ dysfunction.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 04/2006; 101(3):e71-5. · 1.50 Impact Factor
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    ABSTRACT: The relation between disease severity and the known mediators of pain, inflammation, and tissue damage-prostaglandin E 2 (PGE 2 ), leukotriene B 4 (LTB 4 ), malondialdehyde (MDA), nitric oxide (NO), and myeloperoxidase (MPO)-was examined in the synovial fluid of patients with internal derangement (ID) of the temporomandibular joint (TMJ). Thirty-two patients with ID were classified according to Wilkes by clinical and radiological examinations, and TMJ synovial fluid samples were obtained by arthrocentesis. PGE 2 and LTB 4 levels were measured by ELISA kits, MDA levels were determined by a fluorometric method, myeloperoxidase activity was determined by an end-point method, and NO levels were measured by Griess reaction. The earliest significant increase was observed in NO levels (stage II) and this elevation persisted in the subsequent stages. The first significant elevation in PGE 2 and LTB 4 levels and MPO activity were observed in stage III. Both PGE 2 and LTB 4 levels were increased in stage III and were correlated with each at this stage and in the subsequent stage. Significant increases in MDA levels were observed only in stage IV. At stage IV there was correlation between MDA and PGE 2 , MDA and LTB 4 , and MDA and MPO. The relation between PGE 2 and MDA was the most powerful one. Results of this cross-sectional study point out the relation between disease severity and levels of some molecular mediators in synovial fluid of TMJ. Longitudinal studies are needed to explore the role of these molecular mediators in the progression of ID.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 07/2005; 99(6):666-70. · 1.50 Impact Factor
  • Otolaryngology Head and Neck Surgery 06/2004; 130(5):633-4. · 1.73 Impact Factor
  • Journal of Oral and Maxillofacial Surgery 12/2002; 60(11):1354-6. · 1.28 Impact Factor