ABSTRACT: Synergistic severity of H. pylori and HIV co-infection in dyspeptic patients and its seroprevalence by
socio-economic and environmental factors in this locality was studied. 109 confirmed seropositive HIV patients
suffering from dyspepsia were tested for the presence of H. pylori IgG antibodies from 230 patients, attending outpatient
clinics of Sacred Heart Hospital, Abeokuta, Nigeria. 47.4% has H. pylori and HIV antibodies with significant
H. pylori IgG titre more than 1:40. 29.4% was recorded in age group 26-35 while 3.5% was recorded in 66-75.
Female subjects were more predisposed having 52.7% to the disease while 27.5% have malaria as associated
disease. Unemployed individuals are 17.4% with a significant titre of 1:60 compare to artisan with 36.7% prevalence
rate but with low titre of 1:20. Low CD4 count of 213cell/mm3 among 17.4% unemployed and 405 cell/mm3 among
36.7% artisan was observed. Prevalence of H. pylori in HIV is correlated to poor socio-economic condition (that is
low daily income), associated low-level of education and overcrowding which could predispose many HIV
seropositive individuals to severe dyspepsia and other severe disease conditions.
New York Science Journal. 09/2011; 4(9):1-5.
ABSTRACT: Abstract: Crystalline silica has recently been reported to act as an adjuvant which increases inflammation and antibody production. On the basis of new knowledge, it is possible that cement dust may have effects on the immune functions of cement factory workers. Previous studies on Nigerian cement factory workers were concentrated on the pulmonary function tests, chronic obstructive pulmonary disease (COPD), prevalence of chest infections and liver function tests neglecting the immune parameters of the cement workers. The present study determines the levels of serum immunoglobulin classes (IgA, IgM, IgG & IgE) and Alanine aminotransaminase, Alkaline phosphatase, total bilirubin and gamma glutamyl transferase in 45 male cement factory workers that are occupationally exposed to cement dust compared with 30, age and sex-matched, office workers that were not resident in the town of study. Immunodiffusion method was used to determine serum IgA, IgM, IgG while ELISA method was used to determine serum IgE. Alkaline phosphatase(ALP), alanine amino transferase(ALT), bilirubin were determined using Hitachi 902 auto analyser while gamma glutamyl transferase(GGT) was determined using colorimetric method. The levels of IgM and IgA were not statistically different in cement factory workers compared with control (p>0.05) while IgG and IgE were significantly higher in cement factory workers (p<0.05) when compared with corresponding levels in the controls. Also, ALP and bilirubin were higher in the test subjects than in control group (p<0.05). Though the mean levels of ALT and GGT were not statistically significantly higher cement factory workers when compared with control group (p>0.05). This study demonstrated that higher level of IgG may be a mechanism to block anaphylaxis reaction of IgE in Nigerian cement factory workers. The raised ALP and bilirubin levels may suggest hepatotoxic effects of cement dust. [Researcher 2010;2(4):55-58]. (ISSN: 1553-9865).
Key-words: Silica, Cement dust, Nigeria, Immunoglobulin, Liver.
RESEARCHER. 01/2010; 2:55-58.
(5TH Biennial Scientific Conference of Association of Clinical Chemists of Nigeria and Inauguration of African Federation of Clinical Chemistry, Ibadan, Nigeria, Ibadan, Nigeria; 01/2009
ABSTRACT: ABSTRACT: Increasing renal debility among various age groups in recent past has shifted public attention on the prevalence of renal diseases caused by enterohaemorrhagic eschericia coli serotype 0157:H7 (EHEC 0157:H7) in Abeokuta, Nigeria as a result of consumption of unproperly cooked meal especially of bovine source. This study spanned through a period of 23 months between February 2006 to November 2007 with total urine sample of 1205 from various age group including known UTI patients and related diseases (988) and Non-UTI patient 217 which serves as control group. All the urine samples were investigated for EHEC 0157:H7. E.coli serotype accounted for 372(46.4%) of all the isolates like Pseudomonas aeruginosa 74(9.2), Staphlococcus albus 122(15.2), Proteus mirabilis 51(6.4%), klebsiella specie 147(18.3%), staphylococcus aureus 36(4.5%).Age group 41-50 male shows highest prevalence of 1/3(33%) , while female age group 6-10 having 1/11(9.0%), 11-20(6.7%). 21-30, 6/8(7.5%), 41-50 ½(8.3%), suggesting that female were more predisposed to UTI and its related diseases. Incidence of E.coli0157:H7 in chronic PID and gynaecological condition having 1/9(11.1%) inferred that E.coli0157:H7 could as well be responsible to this disease condition and foetal debilities. Most of the isolates were verocyto-toxin producers with 112 out of 223(5.4%) in severe UTI and all produce type-1 and 2 verocytotoxin and likewise in chronic PID and gyaenecology conditions. This study shows a very high prevalence of E.coli0157:H7 in this area which could be a major aetiological cause of renal diseases. Attention should be more paid to undiagnosed hemolytic colitis and hemolytic uremic syndrome caused as a result of severe UTI in developing countries with aggressive strategic public health campaign in preventing secondary transmission .The study is statistically significant (p<0.05). [The Journal of American Science. 2008; 4(2):4-9].
The journal of American Science. 01/2008; 2:4-9.