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Gastroenterology 01/2011; 140. · 11.68 Impact Factor
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ABSTRACT: Neonatal enteric fever is a rare but life-threatening illness. Patients may present with varying severity, Salmonella enterica serotype Typhi causing more severe illness than Salmonella enterica serotype Paratyphi A. Salmonella enterica serotype Paratyphi A is considered to cause milder infection with fewer complications. We report a rare case of vertical transmission of Salmonella enterica serotype Paratyphi A with severe complications and high mortality. Even though there are case reports of vertical transmission of Salmonella enterica serotype Typhi, to our knowledge, this is the first case report of vertical transmission of Salmonella enterica serotype ParatyphiA. The role of blood culture in accurate diagnosis and treatment is also discussed.
The Indian Journal of Pediatrics 09/2007; 74(8):784-6. · 0.52 Impact Factor
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ABSTRACT: This paper reports the antibiotic consumption data of Sir Ganga Ram Hospital, New Delhi and bacterial resistance over a seven-year period. Cephalosporins, penicillins and fluoroquinolones were the most widely prescribed antibiotics. A correlation was seen between Escherichia coli resistance to third-generation cephalosporins and increased cephalosporin use, as well as resistance to co-amoxyclav and its use.
Journal of Hospital Infection 03/2005; 59(2):156-8. · 3.39 Impact Factor
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ABSTRACT: The present report describes use of nucleic acid sequence-based amplification (NASBA) technology to detect pp67 mRNA of cytomegalovirus (CMV) in transplant patients in India. In our experience, pp67 mRNA assay was an accurate, rapid, and effective diagnostic tool to detect active CMV disease in 40.7% (50/123) of symptomatic transplant cases. This assay also allowed us to monitor CMV therapy. As part of the immunosuppressive regimen mycophenolate mofetil was found to increase the risk of developing CMV disease. All positive cases with this assay were subjected to antiviral therapy, with complete remission of the disease. At our center CMV NASBA assay has become the gold standard for the diagnosis of CMV disease in transplant patients.
Transplant Infectious Disease 07/2004; 6(2):90-2. · 2.22 Impact Factor
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ABSTRACT: We report a case of an apparently immunocompetent male, who presented with a painless nodule over the upper abdominal wall. He gave a history of exposure to pigeon droppings. Cryptococcus neoformans was isolated from the lesion and no underlying disorder could be detected. He improved on treatment with oral Fluoconazole.
The Journal of the Association of Physicians of India 04/2004; 52:242-3.
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ABSTRACT: Mixed infection with multiple Salmonella serotypes in the same patient is an unusual finding. We present a case of enteric fever in which the blood culture was sterile and Widal test was negative. The culture of the bone marrow yielded Salmonella typhi and Salmonella paratyphi A.
Indian Journal of Medical Microbiology 20(2):113-4. · 0.99 Impact Factor
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ABSTRACT: Over the last few years, resistance to ciprofloxacin in Salmonella enterica has become a global concern. The present study was undertaken to find out the susceptibility pattern of Salmonella enterica isolates in our hospital.
Blood cultures were done using BacT/ALERT 3D system. The antimicrobial susceptibility testing was carried out by the Kirby-Bauer disc diffusion method using CLSI breakpoints. Minimum inhibitory concentration was determined for ciprofloxacin-resistant strains using E-test and Vitek-1 automated system.
A total of 25,953 samples of blood culture yielded 431 Salmonella enterica serotype Typhi and 198 serotype Paratyphi A isolates. Twenty-two isolates of serotype Typhi were resistant to ciprofloxacin, while two isolates of Typhi and two Paratyphi A were intermediately susceptible to ciprofloxacin. Ciprofloxacin resistance is 5.6% (24 isolates) among Salmonella enterica serotype Typhi. Ampicillin, chloramphenicol and co-trimoxazole resistance in Salmonella enterica serotype Typhi appears to have decreased to 14.9% (64/431) in comparison to the 27% (55/205) during 2003. All isolates were sensitive to ceftriaxone.
Ciprofloxacin can no longer be considered as the drug of choice in treating Salmonella infections. While first-line antimicrobials may still have a role to play in the treatment of enteric fever, ceftriaxone remains the sole defence against ciprofloxacin-resistant Salmonella infections.
Indian Journal of Medical Microbiology 26(1):50-3. · 0.99 Impact Factor
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Indian Journal of Medical Microbiology 22(4):271-2. · 0.99 Impact Factor
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ABSTRACT: Aim: To analyse the correlation of prescribing habits and development of antibiotic resistance over 7 years.
Methods: Prescription auditing of the antibiotics consumed from our hospital pharmacy and resistance of
E. coli and S. aureus to various antibiotics was analysed from Jan 1995 to Dec 2001. Results: Resistance
to b lactams has been high (80-90%) in E coli; whereas in S.aureus the resistance has gone up from 60%
to 98%. Oxacillin resistance has increased from 20% to 50%, while Clindamycin resistance has
remained between 20-25%. The use of Coamoxyclav has increased since '98, after which an increase in
resistance of E coli and S aureus to the same has been noted. Resistance to Gentamicin in E coli is
presently 70% as compared to 30% in '95, while S.aureus resistance has increased from 22% to 50%.
Amikacin is the most widely prescribed aminoglycoside. Prescription auditing has helped formulation of
antibiotic policy.
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