A Trabelsi

Publications (33)8.14 Total impact

• Article: Carcinome endométrioïde développé sur une endométriose du mésocôlon sigmoïde: à propos d’une observation

  A. Trabelsi, W. Stita, L. Harzallah, M. Laarif, M. Mokni, S. Korbi
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  ABSTRACT: L’endométriose dégénérée est très rare. Elle siège électivement au niveau des ovaires et est rarement extragonadique. Nous rapportons l’observation d’un carcinome endométrioïde développé sur une endométriose du mésocôlon sigmoïde chez une patiente de 45 ans. La tumeur a été révélée à l’examen tomodensitométrique réalisé devant la présence d’algies pelviennes. La patiente a subi une hystérectomie totale avec annexectomie bilatérale et une biopsie exérèse du foyer tumoral. À l’examen histologique, la tumeur correspondait à un adénocarcinome endométrioïde dont les cellules exprimaient l’anticorps anti-CK7 et n’exprimaient pas l’anticorps anti-CK20. Notre observation semble être unique dans le sens où le signe d’appel n’était pas directement lié à la lésion tumorale. Les douleurs pelviennes révélatrices étaient liées plutôt à la collection sanguine secondaire au saignement cyclique du foyer d’endométriose. De ce fait, la tumeur est découverte à un stade précoce et le diagnostic s’est fait sur un fragment d’exérèse de la tumeur et non pas sur une pièce de résection colique. Degenerate endometriosis is very rare. It is usually found in the ovaries and is rarely extragonadic. We report on an endometrial carcinoma that developed on a sigmoid mesocolon endometriosis in a 45-years old patient. The tumour was discovered by a CAT scan which was performed because of the existence of pelvic pain. The patient had undergone total hysterectomy with bilateral annexectomy and a biopsy of the tumour. The histology examination showed the tumour to be an endometrial adenocarcinoma whose cells express the anti CK7 antibody and do not express the anti CK20 antibody. Our observation seems very unique in the sense that the symptoms were not directly related to the tumour. Pelvic pain was probably more related to blood collection secondary to cyclical bleeding in endometrial area. Because of this, the tumour was discovered at an early stage and diagnosis was made by part of the tumour being excised and not on a piece of colic resection.
  Oncologie 05/2012; 11(5):306-309. · 0.17 Impact Factor
• Article: Tumeurs à cellules géantes de l’os. Particularités anatomocliniques: à propos de 14 cas

  A. Trabelsi, A. Chtioui, W. Stita, S. Mestiri, M. Mokni, B. Sriha, S. Korbi
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  ABSTRACT: IntroductionLes tumeurs à cellules géantes (TCG) de l’os constituent une entité anatomoclinique particulière par leurs aspects morphologiques et leurs caractères évolutifs, en l’absence de critères prédictifs précis. Patients et méthodesIl s’agit d’une étude rétrospective portant sur quatorze cas de TCG diagnostiqués sur une période de 18 ans (1990–2007) au service d’anatomie pathologique de l’hôpital Farhat-Hached de Sousse. Nous avons procédé à une relecture des clichés radiologiques et des coupes histologiques afin de confronter ces données aux aspects cliniques, thérapeutiques et évolutifs. RésultatsNous avons retrouvé: sept TCG de grade I dont cinq ont récidivé localement; sept TCG de grade II associant une récidive locale et des métastases pulmonaires synchrones dans un seul cas; huit TCG ont évolué favorablement sans récidive ni métastase après traitement. ConclusionIl est difficile de connaître le profil évolutif des TCG osseuses en se basant uniquement sur l’analyse histologique; celle-ci doit être confrontée aux données cliniques, radiologiques et biologiques. IntroductionGiant cell tumors of the bone have specific morphologic features and a progressive course pattern but they lack accurate prognostic criteria. Patients and methodWe report a retrospective study of fourteen cases of giant cell tumor of the bone diagnosed in the pathology department of the Farhat-Hached hospital, Sousse city, between 1990 and 2007. The radiological and histological images were reviewed and compared with the clinical and therapeutic data from the patients’ follow-up. ResultsOur results were as follows: five patients out of seven with grade I tumour had a local recurrence; one patient out of seven with a grade II tumour had a local recurrence with synchronous pulmonary metastases; eight patients had a favourable outcome without any recurrence or metastasis. ConclusionThe histological parameters only may not predict the propensity for a giant cell tumor to induce recurrence or metastasis; the clinical, radiological and biological features must be always taken in consideration. Mots clésTumeur à cellules géantes–Os–Pronostic KeywordsGiant cell tumour–Bone–Prognosis
  Oncologie 05/2012; 12:58-61. · 0.17 Impact Factor
• Article: Les tumeurs endocrines rectocoliques: particularités anatomocliniques et thérapeutiques

  A. Trabelsi, T. Achach, S. Rammeh, A. Saadani, L. Jaidane, B. Sriha, S. Korbi
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  ABSTRACT: But de l’étudeLes tumeurs endocrines du tube digestif sont rares et prédominent au niveau de l’intestin greêle et de l’appendice. Au niveau rectocolique, elles sont plus rares et d’évolution plus agressive. Le but de ce travail est de faire le point sur les caractéristiques anatomocliniques des tumeurs endocrines rectocoliques et d’insister sur l’apport de l’immunohistochimie dans leur diagnostic. Matériel et méthodesNous avons colligé sur une période de 15 ans (1992–2006), cinq cas de tumeur endocrine rectocolique diagnostiqués au laboratoire d’anatomie et de cytologie pathologiques du centre hospitalo-universitaire Fahat-Hached de Sousse (Tunisie). Les données cliniques étaient recueillies à partir des dossiers médicaux. Tous les cas étaient revus et reclassés selon la nouvelle classification de l’Organisation mondiale de la santé (OMS) 2000. RésultatsLes patients se repartissent en deux hommes et trois femmes avec un âge moyen de 55 ans. Deux cas de sie`ge colique étaient classés comme un carcinome endocrine peu différencié, trois cas étaient des carcinomes endocrines bien différenciés dont un de siège colique et un rectal. ConclusionLes tumeurs endocrines rectocoliques constituent un groupe particulier de tumeur digestive dont le diagnostic histologique nécessite toujours le recours à l’immunohistochimie; elles doivent être distinguées des adénocarcinomes conventionnels dont la prise en charge et le pronostic sont totalement différents. BackgroundEndocrine tumours of the gastro-intestinal tract are rare and predominate in the small intestine and in the appendix, less commonly in the colon and the rectum. AimThe aim of this study is to analyze clinical and pathologic features of an endocrine tumour of the colon and the rectum diagnosed in the Department of Pathology (Sousse, Tunisia). MethodsFive cases were diagnosed between 1992 and 2006 in our hospital unit. The medical records of the affected patients were analyzed. The pathological material was reviewed and the tumours were classified according to 2000 WHO classification. ResultsThe study population consisted of 2 male and 3 female patients. Their median age was 55 years. Two poorly differentiated endocrine carcinomas of the colon, and one colic and two rectal well differentiated endocrine carcinoma were identified. ConclusionThis study illustrates the importance of adequately diagnosing endocrine tumours because their treatment and prognosis are different from those of conventional carcinoma. Mots clésTumeurs endocrines–Anatomie pathologique–Immunohistochimie–Côlon–Rectum KeywordsEndocrine tumours–Pathology–Immunohistochemistry–Colon–Rectum
  Oncologie 05/2012; 12:77-82. · 0.17 Impact Factor
• Article: Carcinome papillaire du rein: étude rétrospective à propos de six cas

  A. Trabelsi, O. Gharbi, A. Gaieb, M. Mokni, L. Jaidane, B. Sriha, S. Korbi
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  ABSTRACT: IntroductionLes carcinomes papillaires du rein (CPR) représentent une entité anatomoclinique particulière, bien individualisée dans la classification des cancers du rein. Le but de notre travail est de discuter, à partir de six observations, les principales caractéristiques anatomocliniques et thérapeutiques de cette tumeur. Matériel et méthodesIl s’agit d’une étude rétrospective portant sur six cas de CPR, colligés sur une période de dix ans (1997–2006) dans le laboratoire d’anatomie pathologique, CHU de Sousse, Tunisie. Nous avons procédé à une relecture des lames et à une classification des cas en deux types, selon la classification histologique de l’Organisation mondiale de la santé (OMS) 2004. Les aspects histologiques sont confrontés aux données cliniques, thérapeutiques et évolutives. RésultatL’âge moyen des patients (cinq hommes et une femme) était de 68 ans, les signes révélateurs étaient des lombalgies dans trois cas et fortuits dans trois cas. Une néphrectomie élargie était réalisée dans cinq cas et une tumorectomie dans un cas. La taille tumorale variait de 15 à 110 mm, et le caractère multifocal était retrouvédans un cas. La tumeur était de type 1 dans trois cas et de type 2 dans trois cas. L’évolution était favorable dans cinq cas et des métastases étaient retrouvées dans un cas. ConclusionLe CPR est une entité anatomoclinique particulière par son aspect morphologique et son caractère évolutif globalement favorable. IntroductionPapillary carcinomas of the kidney are relatively rare tumors. The purpose of this study was to discuss clinicopathological and imaging features of six cases of papillary carcinoma. Material and methodsIn a retrospective study, we studied the clinicopathological and imaging features of six cases of papillary carcinoma retrieved in a 10-years period at the pathology department of F. Hached hospital (Sousse, Tunisia). These tumors were graded according to the new 2004 WHO histopathological classification of renal tumors, on which the prognosis depends. ResultsIn our study, there were five men and one woman. The median age was 68 years, the tumors were asymptomatic in three cases and revealed by lumbar pain in the other three cases. Treatment consisted of radical nephrectomy in five cases and tumorectomy in one case. The tumors measured 15 to 110 mm. The tumor was multifocal in one case. Histopathological examination found type 1 in 3 cases and type 2 in three cases. Metastases were observed in one case. ConclusionRenal papillary carcinoma represents a specific group characterized by their less aggressive behaviour. Mots clésCarcinome papillaire–Rein–Anatomie pathologique KeywordsPapillary carcinoma–Kidney–Pathology
  Oncologie 04/2012; 12:40-44. · 0.17 Impact Factor
• Article: Adénocarcinome colique révélateur de tumeurs carcinoïdes multiples du grêle

  T. Achach, A. Trabelsi, M. Taher Yacoubi, B. Sriha, A. Ben Ali, S. Korbi
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  ABSTRACT: Les tumeurs neuroendocrines (TNE) du grêle sont souvent de découverte fortuite. Elles peuvent être multiples comme elles peuvent s’associer à d’autres tumeurs synchrones, notamment gastro-intestinales. Nous rapportons un cas rare d’un homme, âgé de 68 ans, chez lequel on a découvert, lors de la résection chirurgicale d’un adénocarcinome colique, de multiples TNE du segment iléal. À travers cette observation et après une revue de la littérature, nous insistons sur le caractère multiple des TNE et sur la possibilité d’association à d’autres tumeurs malignes synchrones. Neuroendocrine tumors of the small intestine are often discovered by accident. This tumor can be multiple and can be associated with other tumors, particularly gastrointestinal malignancy. We present a rare case involving a 68-year-old man in whom we discovered multiple neuroendocrine tumors in the ileum, associated with colonic adenocarcinoma. Following this observation we wish to draw attention to the concept of multiple neuroendocrine tumors and the possibility of synchronous malignancy. Mots clésTumeurs neuro-endocrines multiples–Adénocarcinome–Tumeurs synchrones KeywordsMultiple neuroendocrine tumors–Adenocarcinoma–Synchronous tumors
  Oncologie 04/2012; 12:1-3. · 0.17 Impact Factor
• Article: Le carcinome adénoïde kystique du sein: à propos d’un cas et revue de la littérature

  A. Trabelsi, O. Chouchene, A. Chtioui, M. Taher Yacoubi, S. Korbi
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  ABSTRACT: Le carcinome adéno:ide kystique est une tumeur rare du sein caractérisée par son aspect morphologique particulier. Par opposition à son homologue à localisation extramammaire, le carcinome adénoïde kystique du sein est réputé de bon pronostic même si des cas de récidives locales ou de métastases viscérales ont été rapportés dans la littérature. Il doit être distingué du carcinome intracanalaire d’architecture cribriformeet du carcinome cribriforme invasif de pronostic différent. À partir d’une nouvelle observation, nous discutons les principales caractéristiques anatomopathologiques de cette entité rare tout en insistant sur l’apport de l’immunohistochimi dans son diagnostic. Adenoid cystic carcinoma is a rare type of breast cancer with distinctive histology. In contrast to extra-mammary localisation, the prognosis of adenoid cystic carcinoma of the breast is excellent although recurrence and distant metastases have been described. It can be confused with other more common breast cancers such as intra-ductal or invasive cribriforme carcinoma. We report a new case and we discuss the mainly clinical and pathological features.
  Oncologie 04/2012; 10(10):628-631. · 0.17 Impact Factor
• Article: [Ghost cell odontogenic carcinoma of the mandible].

  A Slama, N Boujelbène, L Ben Yacoub, A Trabelsi, H Khochtali, B Sriha
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  ABSTRACT: Ghost cell odontogenic carcinoma is a rare malignant tumor that occurs both in the mandible and maxilla. It has a variable non-specific clinical and radiological appearance. The authors report a mandibular case. A 89-year-old man consulted for swelling of the left lower mandible and gums having developed over the previous 8 months. The lesion was 6cm long, ulcerative and budding, bleeding on contact. Radiological assessment revealed blurred contour osteolysis with extension to the mouth floor and sub-mandibular compartment. Histological examination of the surgical piece supported the diagnosis of ghost cell odontogenic carcinoma. The tumor recurred 2 months later and the patient died 6 months after surgery. Ghost cell odontogenic carcinoma is a rare lesion. The patient was very old. Clinical and radiographic signs were unspecific. Histopathology proved the diagnosis. Evolution was unpredictable due to the wide spectrum of growth patterns. Extensive radical surgery is mandatory due to the high risk of recurrence.
  Revue de stomatologie et de chirurgie maxillo-faciale 06/2010; 111(3):158-61. · 0.35 Impact Factor
• Article: [Primary alveolar soft part sarcoma of the lung].

  A Trabelsi, S Ben Abdelkrim, M Taher Yacoubi, S Mlika, S Hmissa, M Mokni, S Korbi
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  ABSTRACT: Alveolar soft part sarcoma is rare; it mainly appears in the lower extremities in adults and the head and neck in children. Primary pulmonary occurrence of this tumour is exceptional. We report a new case in a 49-year-old man who presented with thoracic pain developing over one month. Imaging showed a tumour in the left upper lobe. Diagnosis of primary alveolar sarcoma of the lung was made by histological examination of a biopsy specimen and elimination of a primary soft tissue tumour elsewhere. Primary alveolar sarcoma of the lung is exceptionally rare and the diagnosis should only be made after eliminating a soft tissue tumour elsewhere.
  Revue des Maladies Respiratoires 04/2009; 26(3):329-32. · 0.59 Impact Factor
• Article: [Solitary fibrous tumor of the nasal cavity: an observation report].

  A Trabelsi, M Bouslama, W Stita, S Ben Abdelkrim, M Mokni, K Bouzouita
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  ABSTRACT: Solitary fibrous tumour is a rare mesenchymal tumour first described in the pleura, but can involve other serosal surfaces and viscera. In the nasal cavity, it is extremely rare. We report a new case in 90-year-old man and discuss the morphologic and evolutive features.
  Revue de laryngologie - otologie - rhinologie 01/2009; 130(4-5):299-300.
• Article: Primary invasive micropapillary carcinoma of the colon: case report and review of the literature.

  A Trabelsi, A B Ali, L B Yacoub-Abid, W Stita, M Mokni, S Korbi
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  ABSTRACT: Invasive micropapillary carcinoma is associated with frequent lymph node metastases and adverse clinical outcome. It has been reported in breast, urinary bladder, lung and the parotid gland, but very rarely in the colon. We report a new case in a 63-year-old man involving the colon, and discuss the clinicopathologic features of this rare and particularly aggressive tumour.
  Pathologica 11/2008; 100(5):428-30.
• Article: A history of partial complex seizures in a 30-year-old woman.

  A Trabelsi, W Stita, S Mestiri, O Gharbi, I Bellara, M T Yacoubi, S Korbi
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  ABSTRACT: Dysembryoplastic neuroepithelial tumour is an uncommon lesion of the brain characterised by a heterogeneous population of neurons, astrocytes and oligodendroglia-like cells. Most patients are young adults with a long history of drug-resistant seizures. We report a case of a 31 year-old woman with a history of severe epileptic attacks. Cerebral imaging showed a left temporal tumour measuring 4 cm in its greater dimension. After surgical intervention, histopathological examination showed a tumoural proliferation with both glial and neuronal components that was confirmed by immunohistochemistry. We also describe the spectrum of dysembryoplastic neuroepithelial tumours and their histological features.
  Pathologica 11/2008; 100(5):411-3.
• Article: Hydatid cyst of the breast: a case report.

  A Trabelsi, R Fatnaci, F Ouni, S Rammeh, S Korbi
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  ABSTRACT: Echinococcal involvement of the breast is extremely rare, even in the endemic countries. We report the case of a 31-year-old woman who presented with a 5 cm mammary mass. Mammography and sonography showed a well-circumscribed cystic lesion. Diagnosis of hydatid cyst was confirmed by pathological examination.
  Pathologica 07/2008; 100(3):197-8.
• Article: Collision epithelial and stromal tumours of the stomach: a case report.

  A Trabelsi, W Stita, M Mokni, T Yacoubi, S Mestiri, S Yahyaoui Sadok Korbi
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  ABSTRACT: Collision epithelial and stromal tumours of the stomach are uncommon, and only a few cases have been reported in the literature. We describe a new case of a 54-year-old man who presented with bloody emesis. An oesophagogastroduodenoscopy revealed a stomach induration, and preoperative histological diagnosis was signet ring carcinoma. Total gastrectomy was performed and histological examination revealed a gastric collision tumour composed of gastrointestinal stromal tumour intermixed with a primary signet ring carcinoma. The neoplastic cells of the gastrointestinal stromal tumour were diffusely positive for CD117, while the signet ring cells were positive for cytokeratin. There was no transition between the two components.
  Pathologica 03/2008; 100(1):18-20.
• Article: Detection of the human Parvovirus B19 in nonimmune hydrops fetalis using immunohistochemistry and nested-PCR in formalin-fixed and paraffin-embedded placenta and fetal tissues.

  H Landolsi, M T Yacoubi, L Bouslama, A Lahmar, A Trabelsi, S Hmissa, M Aouni, S Korbi
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  ABSTRACT: The aim of the present study was to determine whether there is an association between Parvovirus B19 infection and hydrops fetalis setting in fetus and neonate. Twenty-nine samples were analyzed by three methods. Each sample was histologically examined for viral nuclear inclusions in fetal organs and placenta, then immunohistochemical study using Parvovirus B19 antibody that recognized the VP2 protein of the Parvovirus B19 capsid was done in tissue embedded in paraffin (lungs, liver, thymus, kidneys, heart and placenta). Nested-PCR analysis was done after DNA extraction from paraffin blocks and using specific primers of the Parvovirus B19 VP1 gene. Apparent causes of hydrops were eliminated such as metabolic diseases, cardiac failure or malformation. The standard histological study objects viral inclusion in one case (lung tissue). However, the immunohistochemical study was negative in all cases. Nested-PCR demonstrates the presence of the viral DNA in five cases. Our study demonstrates that the implication of Parvovirus B19 in hydrops fetalis must be affirmed by the use of more than one method. Nested-PCR is the most sensitive method in our study and can be easily used for the detection of Parvovirus B19 in formalin-fixed paraffin-embedded tissues.
  Pathologie Biologie 03/2008; 57(3):e1-7. · 1.53 Impact Factor
• Article: [Myoepithelial carcinoma ex-pleomorphic adenoma of the parotid gland].

  S Rammeh-Rommani, A Trabelsi, W Stita, M Mokni, L Jaidane, M T Yakoubi, R Moatemri, S Korbi
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  ABSTRACT: Myoepithelial carcinoma accounts for less than 1% of salivary gland malignant tumors. It may develop de novo or, in approximately 50% of the cases, from a pleomorphic adenoma. A 57-year-old man with a history of a pleomorphic adenoma of the parotid treated surgically 6 years earlier, presented with a 2 cm tumor mass, palpable in the scar region. The histological examination and immunohistochemical study revealed a low-grade myoepithelial carcinoma. The patient had no complementary treatment. He presented 5 years later with a 2 cm parapharyngeal recurrence which was resected. There was no evidence of recurrent tumor or of distant metastasis at 4 year follow-up. Although myoepithelial cells are often predominant in pleomorphic adenomas, carcinomas developing in pleomorphic adenomas show in most cases a glandular differentiation and myoepithelial carcinomas are rare. Currently the diagnostic criteria, the prognosis, and the management of myoepithelial carcinomas are not well documented. Invasive carcinomas developing in pleomorphic adenoma are known to be highly aggressive neoplasms and myoepithelial carcinomas ex-pleomorphic adenoma seem to have a better prognosis. Our reported case was characterized by the weak aggressiveness of the lesion.
  Revue de Stomatologie et de Chirurgie Maxillo-faciale 12/2007; 108(5):465-7. · 0.25 Impact Factor
• Article: [Synovial cyst of the temporomandibular joint].

  R Moatemri, O Farroukh, H Belajouza, A Trabelsi, A Ayache, H Khochtali, A Bakir
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  ABSTRACT: OBSERVATION: A 30-year-old patient presented with a left painful pre-auricular tumefaction for one year. CT-scan suggested the diagnosis of temporomandibular synovial cyst or first branchial cleft cyst. This was confirmed by surgery. DISCUSSION: Temporomandibular synovial cysts are rare, the etiology is not documented. Revealing symptoms are those mentioned above. The common treatment is surgery.
  Revue de Stomatologie et de Chirurgie Maxillo-faciale 07/2007; 108(3):241-2. · 0.25 Impact Factor
• Article: Perivascular epithelioid cell tumor of the uterus: a case report.

  S Rammeh Rommani, A Trabelsi, L Attia, I Msakni, A Koubaa, S Ben Jilani, R Zermani
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  ABSTRACT: A case of a perivascular epithelioid cell tumor (PEComa) arising in the uterus of a 35-year-old woman is presented. Imaging studies revealed a 5 cm well circumscribed mass in the uterine fundus. The tumor was composed of clear to faintly eosinophilic, epithelioid and spindled cells. Immunohistochemically, most tumour cells were strongly positive for HMB-45, smooth muscle actin and desmine, but negative for epithelial markers, S-100 Protein and neuroendocrine markers. Reevaluation of the patient for signs of tuberous sclerosis complex after the diagnosis gave negative results. At the most recent follow-up 4 months later there was no evidence of recurrence.
  Pathologica 01/2007; 98(6):649-51.
• Article: [Salivary duct carcinoma].

  S Mestiri, B Sriha, S Ziadi, A Trabelsi, M Trimeche, M Bouzaiene, S Korbi
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  ABSTRACT: Salivary duct carcinoma is a very rare tumor of the salivary glands that has been principally reported in the parotid gland. It displays histologically a striking similarity to ductal carcinoma of the breast. We report the case of a salivary duct carcinoma arising in the parotid gland of a 62 year-old man. The fact that the tumor was confined to the parotid gland has allowed a radical treatment. After two year follow-up, there was no evidence of recurrence. This tumor is characterized clinically by local aggressiveness, frequent metastatic evolution and poor prognosis. This case report illustrates both the clinicopathological features and the prognostic factors of this entity.
  Revue de Stomatologie et de Chirurgie Maxillo-faciale 12/2006; 107(5):386-8. · 0.25 Impact Factor
• Article: [High-grade maxillary chondrosarcoma during pregnancy].

  S Mestiri, E Mutijima, B Sriha, S Ziadi, M Trimeche, R Mootamri, A Trabelsi, A Bakir, S Korbi
  Revue de Stomatologie et de Chirurgie Maxillo-faciale 03/2006; 107(1):50-1. · 0.25 Impact Factor
• Article: [Well differentiated neuroendocrine carcinoma of the stomach: a case report].

  L M Hachicha, A Trabelsi, S Hmissa, M Mokni, B Sriha, I Hachicha, S Korbi
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  ABSTRACT: Gastric well differentiated endocrine carcinomas were previously believed to be rare lesions, representing less than 1% of gastric neoplasms. These tumours are often associated with chronic atrophic gastritis, rarely with Zolling-Ellison syndrome. Some sporadic lesions are rarely reported. The prognosis is relatively good, but sporadic forms are more aggressive. We report a case of gastric endocrine carcinoma developed by a 52 year-old man classified as sporadic form after many investigations. Through this observation and after a review of literature, the clinicopathologic features of these tumours, their histogenesis and clinical behaviour are reviewed and discussed.
  Revue médicale de Liège 12/2005; 60(11):842-4.