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Biulleten' eksperimental'noĭ biologii i meditsiny 04/2000; 129(3):317-20.
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ABSTRACT: A vascular system of several strains of brain tumors: neurinoma 46-1, gliomas: 11-9-2 and 101-8 were investigated by means of automatic analysis of microangiograms and histochemical-luminescent estimation of endothelial cells. It was shown that the mean quantity of vessels and their section-size in all strains of tumors are less than control independently of the rates of tumor development. The linear density of the endothelial cells appear less that in control vessels and is equal in different strains of tumors, though the inclination to hemorrhages in gliomas is higher than in neurinoma. The cause of this phenomenon is discussed.
Biulleten' eksperimental'noĭ biologii i meditsiny 01/1991; 110(12):638-41.
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ABSTRACT: Arginase activity was studied in the brain and other tissues of the rat at the different periods of neurinoma growth. The activity of the enzyme was considerably activated in the affected hemisphere on the 4th day, in the skin of the head and thigh on the 6th day after tumor transplantation. Elevation in arginase activity in the neoplasm itself was recorded on the 16th day. The data obtained point to the physiological significance of arginase during neurinoma growth.
Biulleten' eksperimental'noĭ biologii i meditsiny 09/1985; 100(8):230-1.
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ABSTRACT: Activity of arginase and of its isoenzymes was studied in rat brain tissue and in neurinoma tissue (strain 10-13-3) at the period of growth of the tumor in trigeminal nerve. Within the fourth day after the tumor transplantation the total activity of arginase was increased in brain and distinct alterations were found in the isoenzyme spectrum, mainly in the impaired hemisphere. The enzymatic activity was increased in the tumoral tissue within 16 days; the activation was localized in the malignant tissue and did not extent into surrounding nerves. In all the samples studied the positively charged isoenzyme I was activated, whereas the activity of the isoenzyme II was altered only slightly and usually tended to decrease. It was the activity of the isoenzyme I, which appeared to be altered in the growing tumor.
Voprosy medit͡sinskoĭ khimii 31(5):84-7.
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ABSTRACT: Isoenzyme spectrum and total activity of arginase were studied in rat brain during growth of transplanted neurinoma and glioma as well as in malignant tissues of human brain. After transplantation of the tumors two peaks of arginase activation were observed within 2-4 days in rat brain tissues and within 16 days in tumoral tissue. Positively charged isoenzyme I of arginase was mainly activated but activity of neutral isoenzyme II was unaltered or slightly decreased. In human brain tumors activity of isoenzyme I was also prevailed, while activity of isoenzyme II was increased in some cases. Regulation of the arginase activity appears to occur by a complex mechanism and the enzyme plays a key role in development of nervous tissue neoplasms.
Voprosy medit͡sinskoĭ khimii 32(6):29-34.
