A Petrone

Publications (5)3.99 Total impact

• Article: Usefulness of a 12-month treatment with finasteride in idiophathic and polycystic ovary syndrome-associated hirsutism.

  A Petrone, R M Civitillo, L Galante, F Giannotti, V D'Antò, G Rippa, A Tolino
  [show abstract] [hide abstract]
  ABSTRACT: Hirsutism is considered as a skin disease due to increased 5 alpha-reductase activity in the pilosebaceous unit and finasteride is a drug that inhibits this enzymatic activity. This study showed the effectiveness of a chronic treatment with a selective 5 alpha-reductase inhibitor, finasteride, in idiopathic and PCOS-associated hirsutism. Finasteride was administered orally at a daily dose of 5 mg for a period of 12 months to 20 women with IH and 20 women with PCOS. Each group was submitted to clinical (with Ferriman-Gallwey method) and serum hormonal (FSH, LH, 17 beta-estradiol, total and free T, delta 4-androstenedione, DHEAS; dihydrotestosterone, 3 alpha-androstanediol glucuronide) studies at baseline and after 3, 6 and 12 months of treatment. After 3 months of finasteride treatment, a significant decrease in the average hirsutism scores was recorded both in IH (p < 0.0001) and PCOS patients (p < 0.0001). A progressive significant decrease of hirsutism score was observed in IH patients after 6 and 12 months (p < 0.002) and in PCOS patients after 6 but not 12 months. In fact, the maximal therapeutic effect on the hirsutism was obtained after 12 months in the IH and 6 months in PCOS group.
  Clinical and experimental obstetrics & gynecology 01/1999; 26(3-4):213-6. · 0.43 Impact Factor
• Article: Finasteride in the treatment of hirsutism: new therapeutic perspectives.

  A Tolino, A Petrone, F Sarnacchiaro, D Cirillo, S Ronsini, G Lombardi, C Nappi
  [show abstract] [hide abstract]
  ABSTRACT: To determine of the clinical and hormonal effects of finasteride (Proscar; Merck, Sharp, and Dohme, Rahway, NJ) in the treatment of idiopathic hirsutism and hirsutism in patients with polycystic ovary syndrome (PCOS). Controlled clinical study. Istitute of Obstetrics and Gynecology, University of Naples "Federico II." Ten women affected by idiopathic hirsutism and 15 women with PCOS. Finasteride was administered orally at a daily dose of 5 mg for a period of 6 months. Rating of hirsutism with the Ferriman-Gallwey method; serum androgen assays. Finasteride produced a reduction in the average hirsutism scores ( > 50% in all patients), whereas no change was observed in serum T, androstenedione, and DHEAS levels. A significant reduction was measured in serum dihydrotestosterone and 3 alpha, 17 beta-androstenediol glucuronide levels. This study demonstrates that symptomatic hirsutism has to be considered as a skin disease associated with the increased activity of the 5 alpha-reductase. It also indicates that the selective 5 alpha-reductase inhibitor, finasteride, is very effective and well tolerated in the treatment of both idiopathic hirsutism and of hirsutism in patients with PCOS.
  Fertility and Sterility 08/1996; 66(1):61-5. · 3.56 Impact Factor
• Article: Puberal hormonal status and vaginal microbiology.

  A Tolino, G Scognamiglio, G Liguori, A Petrone, G Borruto Caracciolo, C Nappi
  [show abstract] [hide abstract]
  ABSTRACT: The Autors have examinated endocrine function in girls during puberal age. Have been showed datums relative to cultures effected on vaginal secrets withdrawn from little girls in prepuberal age. They have also studied polimicrobic vaginal flora related to sexual hormone levels. Have been controllated correlations between vaginal microbic status and cytohormonal response at different hormonal situation. The Doderlein presence is as much greater so higher is the oestrogen and progesterone (E/P) ratio, while the Doderlein bacillus isn't present when E/P ratio is lower. Perhaps in puberal age other factors than oestrogen and progesterone levels, could influence vaginal polymicrobic flora.
  Acta Europaea fertilitatis 25(6):343-6.
• Article: Menopausal hormonal status and vaginal microbiology.

  A Tolino, G Scognamiglio, G Liguori, A Petrone, C Artuso, C Nappi
  [show abstract] [hide abstract]
  ABSTRACT: The authors have examined endocrine function in women during postmenopausal age. They have also studied polymicrobic vaginal flora related to sexual hormone levels. Have been controllated correlations between vaginal microbic status and cytohormonal response at different hormonal situation present in the same woman. In postmenopausal women have been formed low oestrogen levels related to low presence of Doderlein. Perhaps in postmenopausal women other factors than oestrogen and progesterone levels, could influence vaginal polymicrobic flora.
  Acta Europaea fertilitatis 25(6):339-41.
• Article: Subclinical hypothyroidism and hyperprolactinemia.

  A Tolino, M Nicotra, L Romano, A Petrone, L Langella
  [show abstract] [hide abstract]
  ABSTRACT: The authors have studied 25 women aged 22 to 26 years with a diagnosis of prolactinemia moderately increased in primary sterility. Among 25 women under observation, 7 (28%) showed a hormone picture of subclinic hypothyroidism. In fact the evaluation of TSH after stimulation with TRH showed a curve typical of the subclinic hypothyroidism. In 8 women (32%) the authors have found an increase of the thyroid gland, and in 3 patients (12%) galactorrhea. The increase of volume of the thyroid gland was constant in all the women with subclinic hypothyroidism. Considering the results obtained by this study, the authors point out a correlation between subclinic hypothyroidism-hyperprolactinemia and sterility. The data obtained are in accordance with that has been reported in literature.
  Acta Europaea fertilitatis 22(5):275-7.