A Milunsky

Are you A Milunsky?

Claim your profile

Publications (2)9.56 Total impact

  • Source
    Article: The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis.
    S Zhang, W Qiu, H Wu, G Zhang, M Huang, C Xiao, J Yang, C Kamp, X Huang, K Huellen, Y Yue, A Pan, R Lebo, A Milunsky, P H Vogt
    [show abstract] [hide abstract]
    ABSTRACT: The zinc finger gene family represents one of the largest in the mammalian genome, with several of these genes reported to be involved in spermatogenesis. A newly discovered gene has been identified that is expressed abundantly in the testicular tissue of fertile men as determined by mRNA differential display. The gene encodes a C(3)HC(4)-type zinc finger protein motif (ring finger motif) consistent with a role in pre-meiotic or post-meiotic sperm development. The gene was named ZNF230 and mapped to the short arm of chromosome 11 (11p15). ZNF230 has two transcripts, of 1 kb and 4.4 kb in length. The shorter 1 kb transcript was only detected in testicular tissue whereas the longer 4.4 kb transcript was not detected in testis but was found in several other tissues. The lack of detectable ZNF230 expression in azoospermic patients by reverse transcriptase-mediated PCR analysis is interpreted to mean that this gene is involved in maintaining normal human male fertility.
    Biochemical Journal 12/2001; 359(Pt 3):721-7. · 4.90 Impact Factor
  • Article: Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463.
    H Wu, S Zhang, W Qiu, G Zhang, Q Xia, C Xiao, X Huang, M Huang, P Agen, T Fan, J Yang, A Milunsky
    [show abstract] [hide abstract]
    ABSTRACT: A novel human KRAB (Krüppel associated box) type zinc finger protein encoding gene, ZNF463, was obtained by mRNA differential display and RACE. It consists of 1904 nucleotides and encodes a protein of 463 amino acids with an amino-terminal KRAB domain and 12 carboxy-terminal C2H2 zinc finger units. The gene is mapped to chromosome 19q13.3 approximately 4 by FISH. As from Northern blot analysis ZNF463 is only expressed in testis, RT-PCR indicates that ZNF463 is expressed more highly in normal fertile adults than in fetus and azoospermic patients suggesting that it may play a role in human spermatogenesis.
    Biochimica et Biophysica Acta 04/2001; 1518(1-2):190-3. · 4.66 Impact Factor
Browse more researchers