Publications (3)0 Total impact
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ABSTRACT: The purpose of our study was to evaluate some biochemical markers of neuronal metabolism in a classical pattern of behavior, developed by Friedman and Rosenman (1974), the adrenergic "A" type. Epidemiologic studies demonstrated an association between type A behavioral characteristics and specific physipathologic conditions: hypersensitivity to pain, increased heart rate, high systolic blood pressure, bipolar disorders, or specific preferences for atherogenic diet, despite the fact that molecular basis of these findings have not been established, yet. Mice were divided in two behavioral groups, according to their reactivity to painful stimulus (endogenous analgesia): type A (associated with hypersensitivity to pain) and type B ("non-A", the opposite type of behavior) which exhibits hypo reactivity to pain. Mice pain sensitivity was assessed using the hot-plate test (60°C). Cerebral monoaminergic status was assessed by measuring the levels of noradrenaline (NA), dopamine (DA), serotonin (5-HT) using HPLC with electrochemical detection, and γ-aminobutiric acid (GABA) using a fluorimetric assay.
Carol Davila University of Medicine and Pharmacy
Bucharest, Bucuresti, Romania
- Facultatea de Farmacie