A M Wang

Harvard Medical School, Boston, Massachusetts, United States

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Publications (39)118.66 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Stroke is a frequently reported, though uncommon, complication of drug abuse, primarily cocaine. The pathogenesis is uncertain, although such cerebrovascular events may result from sympathetically mediated vasoconstriction of cerebral vessels. Amphetamine, another sympathomimetic amine that is commonly abused, may also cause strokes by producing cerebral vasospasm and/or vasculitis. Amphetamine and its derivatives are frequent adulterants of illegally obtained cocaine and may also be used concurrently; the effect(s) of this combination of drugs upon the cerebral vasculature is not known. Our aim was to develop an animal model that would enable us to study the ability of these drugs to produce acute cerebral vasospasm and to observe the response to IV administration of amphetamine and cocaine, either alone or together. Magnified basilar artery arteriograms were obtained in 12 New Zealand white rabbits before and after IV administration of cocaine, methamphetamine, or both, at various dosages. Low doses produced mild vasodilatation. At higher doses, the animals who received cocaine and methamphetamine alone showed little or no basilar artery spasm, but coadministration produced definite basilar artery vasospasm, reflecting a synergistic vasoconstrictive effect. If a similar response exists in the human cerebral vasculature, then this could help explain the cause of strokes associated with drug abuse.
    American Journal of Neuroradiology 11/1989; 11(6):1141-6. · 3.59 Impact Factor
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    ABSTRACT: Osteogenesis imperfecta is a disease of bone formation subdivided into two types, congenita and tarda. It is associated with bony fragility, blue sclerae and abnormality of tooth dentin. Rarely the tarda form is associated with basilar invagination or infolding of the foramen magnum and upper cervical segments into the posterior fossa. This results in hydrocephalus and a spectrum of neurologic dysfunction known as the foramen magnum compression syndrome. Many radiologic methods have been used to evaluate basilar invagination including plain film and CT. We describe a patient with osteogenesis imperfecta tarda examined with CT, with a unique finding of diffuse cerebral atrophy associated with basilar invagination.
    Computerized Medical Imaging and Graphics 07/1989; 13(4):363-7. DOI:10.1016/0895-6111(89)90217-6 · 1.22 Impact Factor
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    ABSTRACT: A patient with surgical and neuropathologically confirmed subdural sarcoid granuloma was evaluated using angiography, contrast-enhanced CT and MR. MR images were obtained on a superconducting magnet with T1, intermediate and multi-echo T2 weighted sequences. Review of the 2 prior cases of subdural sarcoid granuloma from the literature evaluated with MR confirm the variable nature of signal intensities of the lesion. MR was most useful in anatomically evaluating the lesion and planning neurosurgical intervention but both CT and MR alone, in this case, did not definitely obviate the other differential diagnosis including meningioma en-plaque, lymphoma, or metastasis.
    Computerized Medical Imaging and Graphics 03/1989; 13(2):199-205. DOI:10.1016/0895-6111(89)90201-2 · 1.22 Impact Factor

  • Journal of Computer Assisted Tomography 05/1988; 12(3):536-8. DOI:10.1097/00004728-198805000-00043 · 1.41 Impact Factor
  • James Suojanen · A M Wang · Ken R. Winston ·
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    ABSTRACT: We present a patient with an intraspinal, high-signal-intensity lesion in the lumbosacral region on T1-weighted magnetic resonance images and a thin line of signal void between this region and the CSF on T2-weighted images. These findings were interpreted initially as representing an extradural spinal lipoma. However, CT revealed an intrathecal collection of iophendylate (Pantopaque), which was subsequently removed via a lumbar puncture. The apparent separation of Pantopaque from the CSF (seen on T2-weighted images and interpreted as the dura) was probably caused by chemical shift artifact, chemical shift contour, and/or CSF motion artifact.
    Journal of Computer Assisted Tomography 03/1988; 12(2):346-8. DOI:10.1097/00004728-198803000-00033 · 1.41 Impact Factor
  • A M Wang · J. C. -T. Lin · C L Rumbaugh ·
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    ABSTRACT: This study was based on 5042 cranial CT examinations in a 2-year period. 19.8% of all cranial CT scans were performed for confirmation or evaluation of clinically suspected stroke. 87% of the clinical diagnoses of stroke were confirmed by CT scan. Intracranial hemorrhage made up a small percentage in this study. The establishment of this diagnosis was a valuable service in the patients' management. Brain tumor may rarely present clinical symptoms mimicking stroke and may have a normal CT initially.
    Neuroradiology 02/1988; 30(1):54-8. DOI:10.1007/BF00341944 · 2.49 Impact Factor
  • A M Wang · J H Morris · E G Fischer · R Peterson · J. C. T. Lin ·
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    ABSTRACT: A 25-year-old woman presented with a four-year history of progressive right-lower-extremity weakness and atrophy and a left hemisensory deficit was found. Metrizamide-enhanced spinal CT scan showed an intramedullary lesion at the level of T1-T2; this had expanded the cord in fusiform fashion but showed no evidence of a cystic component. Surgical resection was performed and the pathological diagnosis was cavernous hemangioma. Two and one-half years later, her left hemisensory deficit was worsening and a spinal MRI showed high signal intensity mass in the region of the previous surgery consistent with chronic hematoma which was re-evacuated with some improvement in the patient's neurological condition.
    Neuroradiology 02/1988; 30(3):261-4. DOI:10.1007/BF00341840 · 2.49 Impact Factor
  • J C Lipman · A M Wang · M L Brooks · R M Schick · C L Rumbaugh ·

    American Journal of Neuroradiology 01/1988; 9(4):787-8. · 3.59 Impact Factor
  • A M Wang · Hani A. Haykal · Jackson C.T. Lin · J H Lee ·
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    ABSTRACT: Seven cases of surgically proven intraspinal synovial cysts are reported. Computed tomographic (CT) scans demonstrated a series of low-density masses adjacent to the facet joints; in three cases, a dense rim indicated a calcified wall on the cyst; in one, the wall was partially calcified; and in three the mass appeared to be filled with gas. In all of these cases, there was severe degenerative facet disease at the same level as the synovial cyst. In six patients, the cysts were unilateral, while one was bilateral; seven cysts were located at the level of L4-L5, and one at L3-L4. We conclude from this study that the intraspinal synovial cyst can be identified reliably by the CT scan.
    Computerized Radiology 11/1987; 11(5-6):253-7. DOI:10.1016/0730-4862(87)90008-4
  • Steven E. Seltzer · A M Wang ·
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    ABSTRACT: Tremendous advances in diagnostic imaging technology have produced computed tomography (CT) and magnetic resonance (MR) imaging--new ways to depict the normal anatomy and pathosis of the masseter muscle. This article reviews the masseter muscle's normal appearance on CT and MR images and demonstrates the clarity with which CT, in particular, is able to depict soft tissue lesions and neighboring bony involvement. Analysis of the strengths, weaknesses, and availability of these new techniques leads to the conclusion that CT is currently the test of choice for imaging masseteric lesions but that MR shows greater promise for the future.
    Oral Surgery Oral Medicine Oral Pathology 06/1987; 63(5):622-9. DOI:10.1016/0030-4220(87)90241-6
  • A M Wang · J. C. T. Lin · T C Power · H A Haykal · A A Zamani ·

    Neuroradiology 02/1987; 29(6):590. DOI:10.1007/BF00350453 · 2.49 Impact Factor
  • A M Wang · H A Haykal ·

    American Journal of Neuroradiology 01/1987; 8(2):383-4. · 3.59 Impact Factor
  • H Haykal · A Zamani · A M Wang · J Barsotti ·
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    ABSTRACT: Listeria monocytogenes is a relatively uncommon pathogen affecting infants or adults with predisposing conditions, such as cirrhosis, diabetes mellitus, autoimmune disease, renal transplants, and solid and lymphoreticular malignancies. Cerebral parenchymal involvement is rare and consists of focal cerebritis, which may progress to abscess formation. This article presents three cases of early Listeria monocytogenes cerebritis, two of which demonstrated ill-defined superficial areas of low attenuation with curvilinear gyral enhancement and one of which demonstrated a deep, low-attenuation lesion with faint surrounding enhancement. Although these findings are nonspecific, their early recognition in the proper clinical setting may help institute early antibiotic therapy, which appears to be successful without surgical intervention.
    American Journal of Neuroradiology 01/1987; 8(2):279-82. · 3.59 Impact Factor
  • H A Haykal · A M Wang · A Zamani ·

    American Journal of Neuroradiology 01/1987; 8(5):911-2. · 3.59 Impact Factor
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    ABSTRACT: A carotid-cavernous fistula recurred 16 years after a Hamby procedure. The recurrence was manifested by subarachnoid hemorrhage originating from dilated draining pial veins. The fistula was closed with a balloon catheter introduced through a patent remnant of the cervical carotid artery. Patients who have previously undergone Hamby trapping and embolization should be reassessed for an occult fistula that could predispose them to intracranial bleeding.
    Neurosurgery 11/1986; 19(4):643-8. DOI:10.1227/00006123-198610000-00026 · 3.62 Impact Factor
  • Hani A. Haykal · A M Wang ·
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    ABSTRACT: Air embolism to the brain occurred several days after insertion of an intraaortic balloon pump. CT demonstrated diffuse hemispheric edema along with two small collections of air in the cerebral hemispheres. Early diagnosis of air embolism to the brain allows early institution of proper therapy in this life-threatening condition.
    Computerized Radiology 11/1986; 10(6):307-9. DOI:10.1016/0730-4862(86)90036-3
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    ABSTRACT: Two cases of surgically proven myxopapillary ependymomas of filum terminale are reported. In both, myelography and metrizamide-enhanced computed tomographic (CT) scans were performed. An intramedullary tumor in the lower thoracic spine, soft-tissue masses in the neural foramina and enlarged bony spinal canal in the lower thoracic and upper lumbar spine were noted in one case and, in the other, an intradural extramedullary tumor at T12-L1 level. Both patients had normal cranial CT scans, and both presented with similar symptoms--low back pain and weakness and paresthesia of leg or legs for up to 3 years' duration. Myelography and metrizamide-enhanced CT scans were performed in order to evaluate disc disease in one patient and spinal stenosis in the other. Ependymoma was an incidental finding, which was then removed by surgical resection. Pathology confirmed the diagnosis.
    Computerized Radiology 09/1986; 10(5):239-43. DOI:10.1016/0730-4862(86)90004-1
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    ABSTRACT: A 28-year-old male was found on CT metrizamide myelography to have an intradural extramedullary tumor at the T8-T9 level. This was seen to compress the spinal cord, and on surgery it was proven to be medulloblastoma. Cranial CT scans disclosed only mild hydrocephalus and minimal anterior displacement of the inferior fourth ventricle on the right. However, magnetic resonance imaging (MRI) which was performed after the spinal surgery demonstrated an inferior cerebellar vermian tumor.
    Computerized Radiology 07/1986; 10(4):161-6. DOI:10.1016/0730-4862(86)90100-9
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    ABSTRACT: A 35-year-old woman developed temporal lobe seizures. Isolated dilatation of the right temporal horn was demonstrated by computed tomography. She was asymptomatic for the next 10 months while on anticonvulsants before severe headaches, vomiting, and mental confusion prompted hospitalization. Both temporal horns were now dilated, there was marked periventricular edema, and cryptococci were cultured from the ventricular fluid. She succumbed after prolonged systemic and intrathecal antifungal therapy, having developed isolation and dilatation of both frontal horns and third and fourth ventricles. Cryptococcal or other fungal meningoencephalitis should be considered in the differential diagnosis of isolated dilatations of the ventricular chambers as noted in the present case.
    Surgical Neurology 04/1986; 25(3):253-60. DOI:10.1016/0090-3019(86)90235-1 · 1.67 Impact Factor
  • A M Wang · Amir A. Zamani ·
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    ABSTRACT: A case of intradural herniation of a thoracic (T12-L1) intervertebral disc is reported. On metrizamide myelography, this lesion resembled an intradural extramedullary tumor with an extradural component. A computed tomographic (CT) scan taken immediately after the myelogram, showed gas in the spinal canal and in the intervertebral disc. In addition, it showed a high-density mass located in the ventral epidural space and also intradurally. The density of this soft-tissue mass was identical to that of the intervertebral disc. CT provided very important information regarding the precise location and probable etiology of the lesion, and the success of surgery.
    Computerized Radiology 03/1986; 10(2-3):115-8. DOI:10.1016/0730-4862(86)90054-5

Publication Stats

406 Citations
118.66 Total Impact Points


  • 1983-1989
    • Harvard Medical School
      • Department of Radiology
      Boston, Massachusetts, United States
    • Beverly Hospital, Boston MA
      BVY, Massachusetts, United States
  • 1981-1989
    • Brigham and Women's Hospital
      • • Department of Pathology
      • • Department of Radiology
      Boston, Massachusetts, United States