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Publications (4)18.85 Total impact

  • F Dajas, A Lista, L Barbeito
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    ABSTRACT: The urinary excretion rates of norepinephrine were assayed in 26 patients diagnosed as major depressive disorders (primary, unipolar), before and after 14 days of treatment with the monoamine oxidase inhibitor Moclobemide (Ro 11-1163). A standardized 1-h urine collection procedure was used and norepinephrine was assayed by liquid chromatography with electrochemical detection. Norepinephrine was found significantly increased in depressed patients when compared with a control population. The psychotic patients showed the highest excretion rates although they were not significantly different from the endogenous (non-psychotic) group. Urinary norepinephrine output significantly decreased after 14 days of treatment with Moclobemide. This decrease was also marked in those patients that did not show any therapeutic effect. A clear antidepressant effect, shown by a significant decrease of the Hamilton Scale scores for depression, was apparent as early as the 7th day. Increased norepinephrine in melancholic patients was taken as a presumptive indication of altered sympathetic activity.
    Acta Psychiatrica Scandinavica 12/1984; 70(5):432-7. · 4.86 Impact Factor
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    ABSTRACT: Plasma and urinary catecholamines were measured in a group of schizophrenics and in normal subjects by high performance liquid chromatography with electrochemical detection. A brief procedure for urine sampling performed under standardized environmental and physical conditions was used. Plasma levels and urinary excretion rates of noradrenaline were significantly higher in schizophrenics than in a control population. When plotted for linear regression analysis, both plasma and urinary noradrenaline values were positively correlated (r = 0.75, p less than 0.05). Results reported suggest that urinary catecholamine measurement could be used for a reliable assessment of sympatho-adrenal function in schizophrenia.
    Biological Psychiatry 11/1984; 19(10):1419-25. · 9.25 Impact Factor
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    ABSTRACT: Plasma noradrenaline was assayed in schizophrenics selected according to research diagnostic criteria. Clinical symptomatology was simultaneously rated according to the comprehensive psychopathological rating scale. Global psychopathology, positive (delusional, hallucinatory), negative (autistic), paranoid and hallucinatory symptomatology were separately rated. Noradrenaline was significantly higher in schizophrenics than in a normal control group. A correlation analysis was applied to both psychopathology and plasmatic noradrenaline levels. Noradrenaline was significantly correlated (p less than 0.05 to p less than 0.02) with global psychopathology, positive symptoms and paranoid symptomatology. No correlation was demonstrated between plasma noradrenaline and negative and hallucinatory symptomatology. Plasma noradrenaline is proposed to be related to a high level of sympathetic general activity in schizophrenics, specially associated with paranoid symptomatology.
    Neuropsychobiology 02/1983; 10(2-3):70-4. · 2.37 Impact Factor
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    ABSTRACT: Plasma noradrenaline was assayed in schizophrenics selected according to research diagnostic criteria. Clinical symptomatology was simultaneously rated according to the comprehensive psychopathological rating scale. Global psychopathology, positive (delusional, hallucinatory), negative (autistic), paranoid and hallucinatory symptomatology were separately rated. Noradrenaline was significantly higher in schizophrenics than in a normal control group. A correlation analysis was applied to both psychopathology and plasmatic noradrenaline levels. Noradrenaline was significantly correlated (p < 0.05 to p < 0.02) with global psychopathology, positive symptoms and paranoid symptomatology. No correlation was demonstrated between plasma noradrenaline and negative and hallucinatory symptomatology. Plasma noradrenaline is proposed to be related to a high level of sympathetic general activity in schizophrenics, specially associated with paranoid symptomatology.
    Neuropsychobiology 01/1983; 10(2-3):70-74. · 2.37 Impact Factor