A A Akimov

Publications (5)0 Total impact

• Article: [An experience gained with mantle irradiation in Hodgkin's disease vs. various regimes of dose fractionation].

  N V Il'in, E N Nikolaeva, A A Akimov
  [show abstract] [hide abstract]
  ABSTRACT: Primary patients with stage II-III AB Hodgkin's disease (255) received either standard-fractionated mantle irradiation (SFMI), accelerated hyperfractionation (AHF) or combined treatment using polychemotherapy (CTPT) (1985-1997). Out of 110 patients, 33 (30.0%) were given radiotherapy alone and 77 (70.0%)--combined treatment. Out of 145 patients treated with AHF, that therapy alone was given to 48 (33.1%) and combined treatmento 97 (66.9%). Objective response to primary therapy was reported in 90.0% of SFMI-treated patients and 87.6% of AHF-treated patients. On the whole, the recurrence rates in the SFMI group were higher than in the AHF group (25.5% and 14.5%, respectively, p < 0.05). In the latter group, out of 28 (25.4%) cases of pulmonitis, 10 (30.3%) received radiotherapy alone and 18 (23.4%)--combined treatment. AHF patients developed 19 (13.1%) pulmonites which occurred in that group in 3 (6.3%) SFMI patients and in 16 (16.5%) combined treatment patients. Pericarditis was reported in 11 (4.3%): SFMI- 8 (7.3%), AHF -3-(2.1%), p=0 . 04. To summarize, daily fractionated regimes were followed both by lower rates of relapse and cardiopulmonary complications.
  Voprosy onkologii 02/2005; 51(2):232-5.
• Article: [Dose fractionation for increasing the effectiveness of radiotherapy of tumors].

  A A Akimov, N V Il'in
  Voprosy onkologii 02/2005; 51(6):647-55.
• Article: [Results of radiotherapy in patients with stage-II Hodgkin's lymphoma with mediastinal lymph node involvement].

  N V Il'in, T A Kovryzhkina, A A Akimov, E V Loviagin, I A Shenderova
  [show abstract] [hide abstract]
  ABSTRACT: Depending on size of intrathoracic lymph nodes, 65 patients with Hodgkin's disease (stage II) were divided into two groups using the mediastinal-thoracic index (MTI): MTI = 0.22-0.3 prior to irradiation and MTI (0.3. Mediastinal nodes showed complete regression immediately after therapy (34-49 Gy aimed at mediastinum) in 12.3% only. In 44 patients (67.6%), complete response was not observed until 3-6 months after treatment, sometimes 24 months. Tumor recurred outside area of exposure 2-4 years in 4 (10.8%) in group I and 2 (7%) in group II (p(3.841). No correlation between recurrence rates and intrathoracic lymph node size was established. 10-year survival in both groups was 89.1 and 92.8%, respectively.
  Voprosy onkologii 02/2003; 49(5):643-7.
• Article: [Some biological aspects of Hodgkin's lymphoma and new approaches to therapy].

  A A Akimov, N V Il'in
  Voprosy onkologii 02/2003; 49(1):31-40.
• Article: [Current problems of dose-time correlation in delayed radiotherapy of cancer].

  A A Akimov, N V Il'in
  Voprosy onkologii 02/2000; 46(6):666-75.