ABSTRACT: The up-regulation of VEGF interrelated to tumor angiogenesis provides a target for tumor treatment. We describe the feasibility of using chitosan nanoparticles for successful VEGF-siRNA delivery to finally reduce the VEGF level in a mouse melanoma model in vitro. The chitosan/VEGF-siRNA (CTS/siRNA) nanoparticles were prepared with a size of 110-200nm and zeta potential of ~20mV. Moreover, the stable nanoparticles can successfully transport VEGF-siRNA into cells, and release siRNA for VEGF gene silencing.
Journal of Controlled Release 11/2011; 152 Suppl 1:e160-1. · 5.73 Impact Factor