[Show abstract][Hide abstract] ABSTRACT: Acute pancreatitis and diabetic ketoacidosis are unusual adverse events following chemotherapy based on L-asparaginase and prednisone as support treatment for acute lymphoblastic leukemia. We present the case of a 16-year-old Hispanic male patient, in remission induction therapy for acute lymphoblastic leukemia on treatment with mitoxantrone, vincristine, prednisone, and L-asparaginase. He was hospitalized complaining of abdominal pain, nausea, and vomiting. Hyperglycemia, acidosis, ketonuria, low bicarbonate levels, hyperamylasemia, and hyperlipasemia were documented, and the diagnosis of diabetic ketoacidosis was made. Because of uncertainty of the additional diagnosis of acute pancreatitis as the cause of abdominal pain, a contrast-enhanced computed tomography was performed resulting in a Balthazar C pancreatitis classification.
Case reports in oncological medicine. 01/2014; 2014:139169.
[Show abstract][Hide abstract] ABSTRACT: The aim of our study was to identify the rate of diabetic patients treated for hypothyroidism and compare them with a group without type 2 diabetes mellitus (T2DM).
We reviewed the computerized clinical records of 5161 patients. We identified diabetic patients treated with l-thyroxine. We compared the prevalence of PH with those patients under treatment with levothyroxine without T2DM. We excluded patients with a thyroid neoplasia, thyroid surgery, panhypopituitarism, or surgical complications of multinodular goiter or a thyroid nodule. Subclinical hypothyroidism was not considered.
We included 1848 adult patients with T2DM in the study group, 58% women and 42% men. For the control group, we included 3313 non-diabetic patients, 55% women and 45% men. The mean age in the study group was 52±7 years, and 47±4 years in the control group (p<.001). The rate of hypothyroidism in the study group was 5.7%, and in the control group 1.8% (odds ratio of 3.45; 95% confidence interval 2.51-4.79) (p<.001).
A strong association between T2DM and hypothyroidism was found. We recommend a thyroid profile in all patients with T2DM, similar to the recommendation in type 1 diabetes mellitus.
[Show abstract][Hide abstract] ABSTRACT: Background: Craniopharyngioma is the third most common intracranial tumor in childhood and the most common pediatric tumor in the sellar region. After surgery, most patients develop hormonal deficiencies that require treatment. Objective: To evaluate whether tumor size over 4 cm is associated with the development of postoperative pituitary hormonal deficiencies in children with craniopharyngioma. Research design and methods: We included pediatric patients with the diagnosis of craniopha-ryngioma who underwent surgery between March 2007 and March 2009. We analyzed variables such as age, gender, type of surgery, neurologic deficit before surgery and postoperative pituitary hormonal deficiencies. The patients were divided according to tumor size in group 1 ( 4 cm) and group 2 (> 4 cm). Results: Twenty-two patients were included, 13 in group 1 and 9 in group 2. We did not find statistical differences between tumor size and age, gender, type of surgery and neurologic deficit. When analyzing each hormonal deficiency we did not find statistical differences between these and the variables studied. Conclusions: No associations were found between tumor size and postoperative pituitary hormonal deficiencies in children with craniopharyngioma.