Jaime A Teixeira da Silva

Publications (2)1.65 Total impact

• Source

  Available from: ualberta.ca

  Article: Overview of plant-derived vaccine antigens: Dengue virus.

  Ravindra B Malabadi, Advaita Ganguly, Jaime A Teixeira da Silva, Archana Parashar, Mavanur R Suresh, Hoon Sunwoo
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  ABSTRACT: This review highlights the advantages and current status of plant-derived vaccine development with special reference to the dengue virus. There are numerous problems involved in dengue vaccine development, and there is no vaccine against all four dengue serotypes. Dengue vaccine development using traditional approaches has not been satisfactory in terms of inducing neutralizing antibodies. Recently, these issues were addressed by showing a very good response to inducing neutralizing antibodies by plant-derived dengue vaccine antigens. This indicates the feasibility of using plant-derived vaccine antigens as a low-cost method to combat dengue and other infectious diseases. The application of new methods and strategies such as dendritic cell targeting in cancer therapy, severe acute respiratory syndrome, tuberculosis, human immune deficiency virus, and malaria might play an important role. These new methods are more efficient than traditional protocols. It is expected that in the near future, plant-derived vaccine antigens or antibodies will play an important role in the control of human infectious diseases.
  Journal of pharmacy & pharmaceutical sciences: a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 07/2011; 14(3):400-13. · 1.65 Impact Factor
• Source

  Available from: Md Saifur Rahman Khan

  Article: Targeting strategies and nanocarriers in vaccines and therapeutics

  Saifur Rahman Khan, Advaita Ganguly, Ravindra B. Malabadi, Hoon H. Sunwoo, Archana Parashar, Jaime A. Teixeira da Silva, Mavanur R. Suresh
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  ABSTRACT: In the past few decades, remarkable advances have been made in the field of immunology and molecular biology. Even though the efficacy level, protein binding capacity and other pharmacological parameters are extraordinary, formulations have become more challenging in terms of making drugs or antigens reach specific sites of action, the release rate of a drug at the site of action, proper presentation of an antigen by antigen-presenting cells or dendritic cells and other pharmacokinetic and pharmacodynamic parameters of finished drug products and vaccines. The purpose of this review is to present a brief overview of the challenges to drug targeting, especially vaccines, as well as of different approaches designed to overcome these barriers.
  Research in Biotechnology. 01/2011; 6(2-ISSN: 2229-791X):8-20.