[show abstract][hide abstract] ABSTRACT: This review highlights the advantages and current status of plant-derived vaccine development with special reference to the dengue virus. There are numerous problems involved in dengue vaccine development, and there is no vaccine against all four dengue serotypes. Dengue vaccine development using traditional approaches has not been satisfactory in terms of inducing neutralizing antibodies. Recently, these issues were addressed by showing a very good response to inducing neutralizing antibodies by plant-derived dengue vaccine antigens. This indicates the feasibility of using plant-derived vaccine antigens as a low-cost method to combat dengue and other infectious diseases. The application of new methods and strategies such as dendritic cell targeting in cancer therapy, severe acute respiratory syndrome, tuberculosis, human immune deficiency virus, and malaria might play an important role. These new methods are more efficient than traditional protocols. It is expected that in the near future, plant-derived vaccine antigens or antibodies will play an important role in the control of human infectious diseases.
Journal of Pharmacy and Pharmaceutical Sciences 07/2011; 14(3):400-13. · 2.20 Impact Factor
[show abstract][hide abstract] ABSTRACT: In the past few decades, remarkable advances have been made in the field of
immunology and molecular biology. Even though the efficacy level, protein binding capacity
and other pharmacological parameters are extraordinary, formulations have become more
challenging in terms of making drugs or antigens reach specific sites of action, the release
rate of a drug at the site of action, proper presentation of an antigen by antigen-presenting
cells or dendritic cells and other pharmacokinetic and pharmacodynamic parameters of
finished drug products and vaccines. The purpose of this review is to present a brief
overview of the challenges to drug targeting, especially vaccines, as well as of different
approaches designed to overcome these barriers.
Research in Biotechnology. 01/2011; 6(2-ISSN: 2229-791X):8-20.