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Publications (5)0 Total impact

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    ABSTRACT: Abstract: Introduction: Diabetes is the most common cause of peripheral nerve involvement. Effect of antioxidants in diabetic neuropathic pain is important. The purpose of this study was evaluation of the effect of Angipars on neuropathic hyperalgesia in diabetic rats with a single dose of streptozotocin (STZ). Material & Mmethod: Study on rats weighing 250-300 g was Spraque dawley race. Rats into four groups: control, sham, diabetic recipient Angipars (5-10-20 mg dose in milliliters) and solvents were divided into (at least 8 mice in each group). Result : At the end of the eighth week Hot Plate and Tail Flik test the response time of thermal hyperalgesia was significantly reduced compared to controls was observed in the vehicle group and sham. Angipars administration of 5 mg and 10 mg significantly increased response time to thermal hyperalgesia compared to sham quail was the Hot Plate test. Angipars taking a test dose of 10 mg Tail Flik increased response times when the pain was similar to the control group. Conclusion: The findings indicated that Angipars as an antioxidant caused a significant reduction in neuropathic hyperalgesia in rats with diabetes.
    Hormozgan Medical Journal. 07/2014;
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    ABSTRACT: Objective: Diabetes mellitus with 10% prevalence in human population leads to disorders of peripheral nervous system in many affected patients. It causes various polyneuropathies in which nerve conductionvelocity decreases. The aim of this study was to investigate the effect of cerebrolysinon the treatment of neural injuries resulted from hyperglycemia. Method: Diabetes was induced in male rats weighing 250 ± 25 gr by intraperitoneal injection of 65 mg/kg streptozocin (STZ). Six weeks after STZ injection and appearance of neuropathy in diabetic rats, animals were divided into four groups: experimental, vehicle, diabetic and control. The experimental and vehicle groups received respectively single dose of 5 mg/kg day-1 cerebrolysinand saline intraperitoneally for two weeks. At the end, in order to find the efficacy of cerebrolysin, all groups underwent behavioral and electrophysiological tests as well as histological investigation. Results: Metabolic parameters in different groups showed inefficacy of cerebrolysin in the treatment of metabolic disorders of diabetes. However, electrophysiological investigations showed efficacy of cerebrolysin in the treatment of diabetic neuropathy in rats. Moreover, investigation on morphologic structure of sciatic nerve was evident of the return of axon degenerative changes and myelin splitting in nerve fibers in cerebrolysin-received group. The results of behavioral studies showed increase in recovery in cerebrolysin group. Conclusion: According to the results, treatment of diabetic neuropathy with daily injection of 5 mg/kg cerebrolysin for two weeks improves rats’ condition.
    Diabetes & Metabolism. 03/2014; 5(4).
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    ABSTRACT: ABSTRACT Introduction:Diabetes mellitus is often associatedwith chronic neuropathy, a condition which is due to the disturbance in the function of peripheral nervous system. Studying the effects of antioxidants in relieving neuropathy isof a great clinical importance. The aim of this study was to compare the effect of aqua extract of date and Melatonin in preventing neuropathic hyperalgesia in Streptozotocin-induced diabetic rats. Methods:In this experimental study, 40 male Sprague dawley rats weighing 200-250gr were divided into five groups of control, sham, diabetics+ melatonin and diabetics+ date extract and diabetic+solvent. Diabetes was induced by intraperitoneal injection of streptozotocin (45mg/kg B.W) solved in 0.05M citrate buffer. After confirming diabetes statue, experimental groups received eithermelatonin (10mg/kg/day), date extract (4mg/kg/day) or solvent for a duration of 6 weeks. At the end of the 6 th week, all groups were investigated using Hot plate and Tail flick tests. Analysis of variance with significance level of P<0.05 was used for statistical analysis. Results:In Hot plate test, solvent group showed significant decrease in the time of thermal pain response compared to the non diabetic control group (P<0.01). Date extract group showed an increase in the time of response to thermal pain as compared to the solvent group (P<0.01) in a way that response time was close to that in the non diabetic control group. Although time of response to pain in melatonin-administered group was close to that in the non diabetic control group, melatonin group had no significant difference with other groups. There was no significant difference among groups based on the results of Tail flick test. Conclusion:The results of this study show that both date aqua extract and Melatonin as antioxidants prevent and decrease neuropathic hyperalgesia in diabetic rats. In addition, the protective effect of date aqua extract in prevention of diabetic hyperalgesia is more than Melatonin. Key words:Melatonin – Diabetes – Neuropathy – hyperalgesia
    09/2013;
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    ABSTRACT: Problem statement: Diabetes mellitus occurs mainly with chronic polyneuropathy, and oxidative stress plays an important role in emergence of most neurologic and behavioral changes in diabetic patients. Many studies have focused on the beneficial effects of various antioxidants such as melatonin on diabetic neuropathy. The aim of this study is to evaluate the effect of melatonin in prevention of neuropathy in Streptozotocin-induced diabetic rats. After prescribing Streptozotocin (STZ), treatment rats received melatonin (10 mg kg day −1) or DMSO for a period of 6 weeks. Approach: At the end of the sixth week, non diabetic control group, diabetic control group (sham) and treated rats were examined by thermal pain response tests (hot plate and tail flick). The horizontal and vertical activities of rats were measured in an open field test. After that, Motor Nerve Conduction Velocity (MNCV) of sciatic-tibial nerve recorded. Also, to study morphological alterations resulting from diabetic neuropathy of sciatic nerve, Myelinated Fiber Diameter (MFD), Axon Diameter (AD) and Myelin Sheath Diameter (MSD) were evaluated by light microscope. Results: According to hot plate results, response time to thermal pain at the end of sixth week in sham group showed a significant decrease in comparison with the control group (p<0.01). In hot plate test, although melatonin approximated to the response time to control group, the significant difference was not observed among melatonin receivers and other groups. In the open field test, Total Distance Moved (TDM) and mobility duration showed significant decrease in sham and DMSO groups in comparison to the control and melatonin groups. Diabetic rats treated with melatonin showed significant increase in MNCV compared to sham and DMSO groups (p<0.05). In morphological study, pretreatment with Melatonin significantly reversed sciatic nerve diameters (MFD, AD, and MSD) reduction in diabetic rats. Electron microscopy showed myelin splitting and myelin sheath infolding in diabetic control group compare to non diabetic group. Conclusion: This study showed that melatonin can decrease the destructive progress of diabetes and causes neuroprotection against damages resulting from STZ-induced hyperglycemia.
    American journal of pharmacology and toxicology 01/2011; 6:59-67.
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    ABSTRACT: To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats. The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and vehicle group with respect to the following parameters: open field behavioral test, motor nerve conduction velocity (MNCV), and morphological observations. In the model of STZ-induced of diabetic neuropathy, chronic treatment for 6 weeks with DFE counteracted the impairment of the explorative activity of the rats in an open field behavioral test and of the conduction velocity of the sciatic nerve (MNCV). In addition, pretreatment with DFE significantly reversed each nerve diameter reduction in diabetic rats. DFE treatment shows efficacy for preventing diabetic deterioration and for improving pathological parameters of diabetic neuropathy in rats, as compared with control groups.
    Oxidative Medicine and Cellular Longevity 01/2011; 2011:976948.