Jun Takasaki

Publications (8)0 Total impact

• Article: [Hepatic arterial infusion with subsequent hepatectomy for a sigmoid colon cancer patient with hepatic metastases-a case report].

  Masayuki Ando, Toshiaki Kurokawa, Hideaki Ganno, Yoshihisa Watayo, Akira Fukuda, Takeshi Nagahama, Katsunori Ami, Jun Takasaki, Hidetoshi Amagasa, Ryota Seki, Keiichi Fujiya, Kuniyoshi Arai, Shikofumi Tei, Yoichi Okada
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  ABSTRACT: It is common to use systemic chemotherapy, instead of hepatic arterial infusion (HAI) of 5-fluorouracil (5-FU) or other cytotoxic agents, for unresectable hepatic metastases in colorectal cancer patients. Nevertheless, systemic administration of anticancer agents such as FOLFOX or FOLFIRI is sometimes difficult to continue for infirm patients. A 71-year-old female who had undergone sigmoidectomy for sigmoid colon cancer received HAI for 12 months because of big bilobar hepatic metastases and poor performance status. Thereafter, a two-stage hepatectomy(first, left lobe: second, S7+8 and S5) was performed successfully. She has been alive for 2.5 years after the first operation but with two small lung metastases in the left lobe. Because of bad performance status and her weak social and familial conditions, treatment with standard systemic chemotherapy could not be continued. In such cases, HAI should be performed if the metastases are limited to the liver.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2012; 39(12):2237-9.
• Article: [A case of lung metastasis from esophageal cancer resistant to Fluorouracil and Cisplatin combination therapy but responsive to radiation therapy].

  Katsunori Ami, Ryouta Seki, Jun Takasaki, Hidetoshi Amagasa, Hirotaka Kamikozuru, Hideaki Ganno, Toshiaki Kurokawa, Akira Fukuda, Takeshi Nagahama, Masayuki Ando, Yosuke Yamada, Fumi Kodaka, Kuniyoshi Arai
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  ABSTRACT: At present, fluorouracil and cisplatin combination therapy is the standard chemotherapy against esophageal cancer, but the choice of second-line chemotherapy is controversial. Furthermore, the effect of radiation therapy against lung metastasis from esophageal cancer is unclear. We report a case of lung metastasis from esophageal cancer resistant to fluorouracil and cisplatin combination therapy but responsive to radiation therapy. The patient was a 55-year-old woman who had undergone an operation for esophageal cancer at another hospital. A single right lung metastasis appeared 1 year after the operation. Combined fluorouracil and cisplatin therapy was administrated for 5 courses, but the lung metastasis increased in size. Afterwards, she was admitted to our hospital. We treated her with 14 courses of S-1 and docetaxel combination therapy administered over 13 months. The lung metastasis was decreased for a period. Furthermore, radiofrequency ablation under computed tomography was performed against the lung metastasis re-growth at another hospital. Although the lung metastasis increased in size, no further metastases were detected during the clinical course. The patient was treated with radiotherapy for the lung metastasis re-growth. The tumor had almost disappeared by 10 months after the completion of radiotherapy. Currently, she is receiving palliative care as an outpatient and the lung metastasis has not been evident for 2 years since the completion of radiotherapy.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2012; 39(12):2104-6.
• Article: [Four cases of airway obstruction successfully treated by airway stenting].

  Takeshi Nagahama, Katsunori Ami, Masahiro Nakamura, Keiichi Fujiya, Yoshihisa Watayo, Hidetoshi Amagasa, Jun Takasaki, Hideaki Ganno, Toshiaki Kurokawa, Akira Fukuda, Masayuki Ando, Kuniyoshi Arai
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  ABSTRACT: We report 4 cases of malignant airway obstruction treated by airway stenting. Three cases were caused by esophageal cancer and the fourth case by malignant lymphoma. Two patients with esophageal cancer received chemoradiotherapy after airway stenting and survived for 24 months and 54 months, respectively (without cancer recurrence). One patient with esophageal cancer died of airway bleeding 2 months after stent placement. The malignant lymphoma patient was treated by cyclophosphamide+doxorubicin+vincristine+prednisolone(CHOP) with rituximab. Airway obstruction due to malignancy is an urgent oncological situation that should be treated immediately. Airway stenting shows a marked and immediate improvement in dyspnea. Consequently, the induction of chemoradiotherapy or chemotherapy is possible. Two patients were successfully treated by chemoradiotherapy, of which 1 survived for more than 4 years without any evidence of cancer recurrence. Additional chemoradiotherapy for patients who receive esophageal stenting is controversial because of the high frequency of adverse events. However, chemoradiotherapy after airway stenting may demonstrate acceptable anti-cancer effects with fewer adverse events. Airway stenting was an effective treatment for airway obstruction, and additional treatment is essential for longer survival.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2012; 39(12):1852-4.
• Article: [Examination of the effect of anesthesia on radiofrequency ablation of hepatocellular carcinoma-a patient survey on anesthesia for radiofrequency ablation].

  Jun Takasaki, Kuniyoshi Arai, Masayuki Ando, Takeshi Nagahama, Akira Fukuda, Katsunori Ami, Toshiaki Kurokawa, Hideaki Ganno, Hidetoshi Amagasa, Yoshihisa Watayou, Keiichi Fujiya, Masahiro Nakamura, Satoshi Katagiri, Godai Yoneda, Masakazu Yamamoto, Akiko Saito
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  ABSTRACT: Purpose: Radiofrequency ablation(RFA) is minimally invasive and is easy to perform. In the RFA procedure, puncture and passing of the electrical current are painful. Therefore, some facilities use general anesthesia for RFA. In order to evaluate the use of general anesthesia for RFA of hepatocellular carcinoma, a questionnaire survey was conducted. Methods: With the cooperation of Tokyo liver-tomo-no-kai(Tokyo Liver Association), a questionnaire survey was conducted for patients who underwent RFA. In the survey, data on the following were obtained "type of anesthesia used", "number of RFA treatment points", "duration of treatment", "length of impact of pain", and "if you need to receive RFA treatment again, how would you feel about this." Results: The ratio of local anesthesia (LA) to general anesthesia (GA) was 113:24. The ratios of the numbers of patients who felt pain to those who felt no pain were 64:49 (LA) and 0:24 (GA). The ratios of the patients who wished to not receive RFA again to the patients who were comfortable with receiving RFA were 65:45 (LA) and 4:20 (GA). Conclusion: GA achieves better pain control compared to LA, and the patients who receive GA have greater tolerance of RFA.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2012; 39(12):1843-5.
• Article: [A case of transverse colon cancer without a recurrence lesion after five years from resection of hepatic metastasis].

  Katsunori Ami, Masahiro Nakamura, Jun Takasaki, Yoshihisa Watayou, Hidetoshi Amagasa, Hideaki Ganno, Toshiaki Kurokawa, Akira Fukuda, Takeshi Nagahama, Masayuki Ando, Shikofumi Tei, Youichi Okada, Kuniyoshi Arai
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  ABSTRACT: The treatment of hepatic metastasis of colon cancer was in progress by new biochemical agents. Generally, a resection was the first alternative treatment against hepatic metastasis of colon cancer, but new antitumor agents were more effective than conventional antitumor agents. Disappearance of metastasis for colon cancer treated with only antitumor agents was commenced to report. We were experienced a case of transverse colon cancer without a recurrence lesion after five years from the resection of hepatic metastasis. A case was a 77-year-old man. He was operated against transverse colon cancer in February 2003. Pathological stage was ss, n0, Stage II. In April 2004, serum CEA was increased. CT examination was not detected a hepatic metastasis but ultrasound examination and MRI detected the metastasis at S7 lesion in the liver. In July 2004, he was admitted to S-1 and PSK until October 2004. In December 2004, the lesion of hepatic metastasis was reduced and serum CEA was decreased. But in September 2005, the metastatic lesion was re-grown. A resection for hepatic metastasis was executed in November 2005. After the resection for hepatic metastasis, he was admitted to UFT/ UZEL from January 2006 to October 2006. Present time( June 2011), the lesion of recurrence was not detected by several examinations (CT, MRI, Ultrasound etc).
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2298-300.
• Article: [A case of encephalopathy that was suspected to be caused by chemotherapy for colon cancer].

  Hideaki Ganno, Keiichi Fujiya, Masahiro Nakamura, Jun Takasaki, Yoshihisa Watayoh, Hidetoshi Amagasa, Toshiaki Kurokawa, Katsunori Ami, Akira Fukuda, Takeshi Nagahama, Masayuki Andoh, Kuniyoshi Arai
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  ABSTRACT: We report a case of encephalopathy that was suspected to be caused by chemotherapy for liver metastasis from sigmoid colon cancer. A 72-year-old male was suspected that he had drug-induced eukoencephalopathy because he was presented with physical disorders during the FOLFOX/bevacizumab therapy. Although a brain MRI revealed Alzheimer disease, leukoencephalopathy was not excluded from the diagnoses due to a fact that his findings could not be compared before and after the chemotherapy. If leukoencephalopathy was suspected, chemotherapy should have been discontinued as soon as possible. Although a partial response was achieved, chemotherapy had to be discontinued in this case. The cases whose physical and neurological disorders were at risk due to a past history need an examination for nervous system in order to make a comparison with the findings before and after chemotherapy.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2322-4.
• Article: [A case report of esophageal carcinoma developing esophago-brochial fistula successfully treated by esophageal bypass surgery].

  Takeshi Nagahama, Masayuki Ando, Keiichi Fujiya, Masahiro Nakamura, Jun Takasaki, Yoshihisa Watayou, Hidetoshi Amagasa, Hideaki Ganno, Toshiaki Kurokawa, Katsunori Ami, Akira Fukuda, Kuniyoshi Arai
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  ABSTRACT: We have experienced a case of esophageal carcinoma developing esophago-bronchial fistula that was successfully treated by esophageal bypass surgery followed by chemo-radiation. A man aged 64 years old with developed esophago- bronchial fistula after initial chemo-radiation was undergone a gastric bypass surgery to separate esophagus and bronchus. Though closure of fistula was just 4 months after definitive chemo-radiation, an oral feeding was possible until the death of the patient. Stent placement for esophageal carcinoma was less invasive treatment though chemo-radiation after a stent placement was accompanied by high incidence of stent associated morbidity. Since esophageal bypass surgery can definitely separate airway from esophagus, chemo-radiation with oral feeding can be easily carried out. Esophageal bypass surgery was a treatment recommendation for the patient with esophageal carcinoma invading trachea or bronchus.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2405-7.
• Article: [A case of the long-term survivor of rectal cancer who suffered from successive metastases to ovarium, peritoneum, liver, bone and para-aortic lymphonode].

  Masayuki Ando, Yoshihisa Watayou, Hideaki Ganno, Takeshi Nagahama, Akira Fukuda, Katsunori Ami, Toshiaki Kurokawa, Hidetoshi Amagasa, Jun Takasaki, Masahiro Nakamura, Keiichi Fujiya, Kuniyoshi Arai, Shikofumi Tei, Youichi Okada
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  ABSTRACT: A 37-year-old female, who had undergone a low anterior resection for lower rectal cancer, had been received chemotherapy (FOLFOX4, FOLFIRI) for 2 years because of right ovarian metastasis occurred and removed 9 months after the first operation. One month after 2 years of continued chemotherapy, progressive metastases happened to occur successively (rt lunge, left ovarium, liver, para-aortic lymphonode, Virchow lymphonode and bone). Right upper lobe pnemonectomy was performed first, then, peritonectomy, total hysterectomy with left oophorectomy and a partial resection of the small bowel were done. IRIS, as postoperative chemotherapy, performed with hepatic arterial infusion (HAI) of CPT-11 and 5- FU resulted in getting a minimal response for about 10 months. Because of the hepatic arterial thrombosis at 10 months after the previous operation, we could not continue HAI with systemic chemotherapy, that was resulted in the progresion of mutiple metastases, and that the patient died 62 months after the first surgery. Immunohistochemical analyses with MIB-1 stainning of four surgical specimens revealed 80% positive cells in the cancerous tissues.
  Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2238-40.