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Publications (2)0 Total impact

  • OC Koroye · IM Siminialayi · EN Etebu ·
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    ABSTRACT: The transparent gel of Aloe vera has been used as a nutritional supplement and herbal remedy for centuries. It is claimed to have several therapeutic properties but there is little scientific evidence of its effectiveness and safety. The aim of this study is to investigate the effects of GNLD’s Aloe vera plus on the liver of rats. Eighty apparently healthy, adult Wistar albino rats were divided into five groups, three of which given three different doses of Aloe vera plus twice a day for 14, 28 and 42 days. One of the groups served as control and another was given Aloe vera plus for 28 days, following which the drug was withdrawn for another 28 days. The animals were sacrificed at the end of the experiment. Blood samples and the livers were collected for liver enzyme estimation and histopathological analysis. We found a significant elevation of all the liver enzymes after 14 and 28 days of administration of Aloe vera plus and upon withdrawal of the drug for 28 days, the enzyme levels returned to normal values. The histopathological analysis revealed a number of toxic effects, including portal triditis, myxoid degeneration, intracytoplasmic vacuolization , intraparenchymal haemorrhage and hepatic necrosis. Aloe vera plus caused a time- but not dose-dependent hepatotoxicity which recommends the need for more stringent regulation by food and drug regulatory authorities to ascertain its effectiveness and safety.
    West African journal of pharmacology and drug research 09/2011; 26(1). DOI:10.4314/wajpdr.v26i1.70058
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    ABSTRACT: Abortion is widespread in the Niger-Delta region of Nigeria, with resulting high rates of morbidity and mortality. It is thought that the private sector provides the majority of abortion services in Nigeria as a result of the restrictive abortion law in the country. The oil-rich Niger-Delta region accounts for 90% of the country's resource, is economically active and has increased opportunities for sexual networking. This study assays the attitudes of staff at family planning (FP) services and practices of reproductive health and FP services among private practitioners in four states of Niger-Delta of Nigeria (the states of Edo, Delta, Bayelsa and Rivers). Women who had unwanted pregnancies were attended by 119 (87.5%) respondents. However, only 33 (24.0%) provided services for termination of pregnancy. Indeed, just over half (72; 53.4%) counselled women to continue the pregnancy while fewer (35; 25.9%) referred women to other clinics. However, there was no evidence to suggest that doctors followed up on those women counselled to continue their pregnancies. Most private sector service providers of abortion services in Nigeria (69.7%) are non-specialist doctors. Education of private practitioners in the principles of abortion, post-abortion care and FP is recommended to alleviate abortion-related morbidity and mortality in Nigeria.
    Quality in primary care 01/2011; 19(5):325-34.