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Publications (3)0 Total impact

  • Jian Deng · Jie-Xin Zou · Xian-Min Zhou · Zhong-Dao Wu ·
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    ABSTRACT: Angiostrongylus cantonensis is a lung worm of rat (definitive host). Human, an abnormal host, can acquire the infection by ingesting food containing the infective larvae of this worm (third-stage larvae). Although the larvae cannot develop into adult worm in human body, it moves to human brain and eyes, causing eosinophilic meningitis (EM), meningoencephalitis, or ocular angiostrongyliasis (OA). Here we review papers related to Angiostrongylus cantonensis and angiostrongyliasis cantonensis which were published in recent ten years, and identify the main institutes and principal investigators (PI) who are researching Angiostrongylus cantonensis. We also outline the advances in research on pathogen biology, pathogenesis, diagnostic techniques, epidemiology and prevention, as well as drug developed against Angiostrongylus cantonensis.
    Chinese Journal of Schistosomiasis Control 04/2012; 24(2):228-31.
  • Chong-Feng Huang · Jie-Xin Zou · Shu-Qiang Li · Xian-Min Zhou ·
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    ABSTRACT: To understand the possibility of the survival and reproduction of Oncomelania hupensis robertsoni snails in water network regions in Hubei Province, as well as their expected lifespan after leaving the original propagating environment, so as to provide the basic data and precondition for reducing the infection rates of O. h. hupensis in the lake regions. The O. h. robertsoni snails, smooth-shell, were collected from Danling County, Sichuan Province,and raised in the cages in Baimasi Town of Jiangling County, Hubei Province. The survival and reproduction abilities of the snails were observed on regular time. The O. h. hupensis from Jiangling County, Hubei Province was studied as a control group. The expected lifespan of snails was calculated by using the animal life table. After 3-, 6-month, the survival rates of O. h. robertsoni were maintained more than 75% in the homogeneous and mixed living conditions, still above 20% after 9-month. Compared with the control group, there was a statistically significant difference in the 3-month group (Chi2 three months = 38.641, P < 0.05), there was a significant difference between the homogeneous and mixed groups for the female snail survival rates (Chi2af = 13.255, P < 0.05, Chi2cg = 4.882, P < 0.05), but not in the 6-, 9-month groups (Chi2 six months = 3.253, P > 0.05; Chi2 nine months = 5.017, P > 0.05). Filial generation snails were found after nine months in each group. The expected lifespan of 0. h. hupensis was 41.16 d and that of O. h. robertsoni was 35.84 d in the laboratory. The O. h. robertsoni snails from foreign lands can continually survive and reproduce in water network regions in Hubei. O. h. robertsoni snails have enough survival time to passive remote diffusion after leaving the original propagating environments.
    Chinese Journal of Schistosomiasis Control 04/2011; 23(2):173-7.
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    ABSTRACT: To understand the gastroscopic and pathological characteristics of patients with miasis in Poyang Lake area, and to explore the relationship between schistosomiasis and pathological changes of gastric mucosa. Volunteers with or without schistosomiasis were recruited and divided into a case group and a control group. All the objects were examined by electronic gastroscopy and pathological examinations. Two hundred and fifty-three volunteers diagnosed with chronic or advanced schistosomiasis in the case group showed different degrees of gastric mucosal changes, including 7 cases with schistosomal eggs deposited beneath the gastric mucosa (with an incidence of 2.77%) , 33 cases with dysplastic hyperplasia and intestinal metaplasia (with an incidence of precancerous lesion of 13.04%), and 1 case with gastric cancer. While in the 200 volunteers without schistosomiasis in the control group, the results showed milder gastric mucosal changes, 33 cases were detected with dysplastic hyperplasia and intestinal metaplasia (with an incidence of 7.50%), and 1 case was diagnosed gastric cancer. The difference between the incidences of precancerous lesion in the two groups had no statistic significance (P > 0.05). The incidence and extent of gastric mucosal changes in schistosomiasis patients are higher and more serious than those in non-schistosomiasis patients, and gastrointestinal schistosomiasis is not related to gastric cancer.
    Chinese Journal of Schistosomiasis Control 04/2011; 23(2):154-7.