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ABSTRACT: Problems associated with the administration of anticancer drugs, such as limited solubility, poor biodistribution, lack of selectivity, and healthy tissue damage, can be overcome by the implementation of drug delivery systems. A wide range of materials, including liposomes, microspheres, polymers and recently, carbon nanotubes (CNTs), have been investigated for delivering anticancer drugs on the purpose of reducing the number of necessary administrations, providing more localized and better use of the active agents, and increasing patient compliance. Carbon nanotubes (CNTs) have attracted particular attention as carriers of biologically relevant molecules due to their unique physical, chemical and physiological properties. The exact relationship between the physical-chemical properties of carbon nanotubes, their cell-to-cell interactions, reactivity, and biological/systemic consequences are relevant issues and it is important to know such inter-relationships beforehand to employ the benefits of these nanomaterials without the hazardous consequences. The purpose of this review is to present highlight of recent developments in the application of carbon nanotubes as cargoes for anticancer drugs and in the diagnosis of cancer diseases.
Current Medicinal Chemistry 01/2013; · 4.86 Impact Factor
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ABSTRACT: This work reports for the first time a straightforward solvent-free chemical procedure to gain access to Δ-1-pyrroline grafted onto multiwalled carbon nanotubes by the 1,3-dipolar cycloaddition of the mesoionic 4-methyl-2-phenyloxazol-5(4H)-one.
Chemical Communications 05/2012; 48(54):6836-8. · 6.17 Impact Factor
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ABSTRACT: The results of Raman analysis on multi-walled carbon nanotubes, prepared by catalysed chemical vapour deposition, are used
as a guide for the calibration of the growth parameters, directed to improve crystalline quality and resulting thermal stability
of nanotubes. Under selective growth conditions, the resistance to oxidation in air, as assessed by thermogravimetry measurements,
is found to increase with the establishment of the long-range graphitic order in radial tube direction, as signalled by the
Raman G′/G intensity ratio enhancement. In the range of parameters explored (synthesis temperature: 500–700°C; growth atmosphere:
120cc/min i-C4H10–H2–He mixture with He at 0–25%; i-C4H10/H2 flow ratio: 1–3; metal load and reduction temperature of Fe/Al2O3 catalysts: 17–40wt%, and 500 and 700°C, respectively), the best crystalline quality and the highest oxidative resistance
are achieved by carrying out the synthesis reaction at 700°C in 1:1:0 i-C4H10–H2–He atmosphere over 29wt% Fe catalysts reduced at 700°C. An additional relevant finding is the strong correlation evidenced
between results of thermogravimetry and Raman analyses, suggesting the use of Raman spectroscopy for non-destructively evaluating the thermal stability of any graphitically ordered carbon species.
Journal of Materials Science 04/2012; 45(3):783-792. · 2.02 Impact Factor
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Daniela Iannazzo,
Anna Piperno,
Angelo Ferlazzo, Alessandro Pistone,
Candida Milone,
Maurizio Lanza,
Francesco Cimino,
Antonio Speciale,
Domenico Trombetta,
Antonina Saija,
Signorino Galvagno
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ABSTRACT: We report the synthesis and the characterization of different multi-walled carbon nanotubes (MWCNTs) linked to natural molecules, 5,7-coumarins and/or oleic acid, obtained from purified pristine MWCNTs by a cascade of chemical functionalization. The activities of these modified MWCNTs were investigated in vitro on human umbilical vein endothelial cells (HUVECs) by evaluating their ability to influence cell viability and to induce cell apoptosis. Our data showed that pristine MWCNTs are markedly cytotoxic; conversely, the carboxylated carbon nanotubes, much more readily dispersed in aqueous solutions and CNT-Link, the key intermediate designed by us for the drug anchorage, are biocompatible at the tested concentrations (1 and 10 μg ml(-1)).
Organic & Biomolecular Chemistry 12/2011; 10(5):1025-31. · 3.70 Impact Factor
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ABSTRACT: Multi-walled carbon nanotubes (MWCNTs) are prepared by chemical vapor deposition (CVD) in C2H6 + H2 mixture over 20%Fe/SiO2 catalysts. The effects, in terms of yield and selectivity of the growth process, of the changes in composition (H2 at 0–75%) and flow-rate (100–150 sccm) of gas-mixture, catalyst reduction-temperature (400 °C and 650 °C), temperature (750–850 °C) and duration (0.5−6 h) of the synthesis-reaction are investigated. Although yield to C deposits improves by increasing gas flow-rate, temperature or duration of the synthesis-reaction, and by diminishing H2 volume fraction in growth atmosphere, it never exceeds 90% due to the heavy catalyst encapsulation. Moreover, the results of morphological and structural analyses show that a loss of selectivity towards nanotubes and a deterioration of CNT crystalline quality generally accompany the yield enhancement. This suggests the unsuitability of the ethane decomposition over silica-supported Fe-catalysts to the large-scale production of CNTs. Nevertheless, the nanotubes attained might be profitably used in all applications exploiting the magnetic properties originating from the encapsulated iron. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Physica Status Solidi (A) Applications and Materials 07/2008; 205(10):2422 - 2427. · 1.46 Impact Factor
